Article
Oncology
Yi Cheng, Guiying Wang, Lianmei Zhao, Suli Dai, Jing Han, Xuhua Hu, Chaoxi Zhou, Feifei Wang, Hongqing Ma, Baokun Li, Zesong Meng
Summary: The study found that PPM can inhibit CRC cell proliferation, induce cell apoptosis, and promote G0/G1 cell cycle arrest. Additionally, PPM's effect may be related to the PI3K/AKT signaling pathway, with minimal impact on mouse functions and enhanced anticancer effects when combined with 5-FU.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Zhang, Pham Ngoc Khoi, Bangrong Cai, Dhiraj Kumar Sah, Young-Do Jung
Summary: This study reveals a novel effect of sulforaphane (SFN) in stimulating eNOS activity in cells by regulating NO bioavailability, suggesting its potential as a promising therapeutic candidate for preventing endothelial dysfunction, atherosclerosis, and other cardiovascular diseases.
Article
Environmental Sciences
Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun
Summary: The active constituent 1-Monopalmitin (1-Mono) in Mougeotia nummuloides and Spirulina major inhibits the proliferation of lung cancer cells and induces apoptosis through the PI3K/Akt pathway. It also suppresses autophagy, and combining with autophagy inhibitor Chloroquine enhances its cytotoxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ziyi Wang, Xuesong Wang, Zhe Guo, Haiyan Liao, Yan Chai, Ziwen Wang, Zhong Wang
Summary: This study analyzed the molecular mechanism of Reduning (RDN) in the treatment of sepsis using network pharmacology. It was found that RDN significantly inhibited LPS-induced apoptosis by activating the PI3K-AKT signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Huayuan Liu, Caiyun Liu, Mengya Wang, Dongxu Sun, Pengcheng Zhu, Ping Zhang, Xueying Tan, Guangjun Shi
Summary: In this study, the target of Tanshinone IIA (Tan-IIA) in Cholangiocarcinoma was identified through network pharmacology-based prediction, and the possible mechanism was investigated through experimental verification. Tan-IIA was found to inhibit the proliferation and migration of Cholangiocarcinoma cells, induce apoptosis, and exert anti-cancer effects by inhibiting the PI3K/Akt/mTOR signaling pathway.
SCIENTIFIC REPORTS
(2021)
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Shiqing Jiang, E. Zhang, Hang Ruan, Jiahui Ma, Xingming Zhao, Yaoyao Zhu, Xiaoyu Xie, Ningning Han, Jianjiang Li, Hao Zhang, Weidong Xie, Xia Li
Summary: Actinomycin (Act) V induces apoptosis in colorectal cancer cells via mitochondrial dysfunction and inhibition of the PI3K/AKT pathway, presenting a potential targeted therapy option for CRC.
Article
Chemistry, Medicinal
Hui Shan, Xin Zhang, Yalu Mi, Jihui Jia, Bo Wang, Qing Yang
Summary: This study identifies eriodictyol as the most effective anti-gastric cancer flavonoid from Polygoni orientalis Fructus (POF) and investigates its potential targets in gastric cancer. Eriodictyol exhibits inhibitory effects on gastric cancer cell viability, suppresses colony formation, induces cell apoptosis, and inhibits tumor growth in vivo. Network pharmacology analysis suggests that the PI3K/AKT signaling pathway may be a potential target for eriodictyol in gastric cancer.
Article
Medicine, General & Internal
Mingyan Yao, Jing Zhang, Zhihong Li, Xiaoliang Bai, Jinhui Ma, Yukun Li
Summary: The study demonstrates that liraglutide can protect nucleus pulposus cells from high glucose-induced apoptosis by activating the PI3K/AKT/mTOR/caspase-3 and PI3K/AKT/GSK3 beta/caspase-3 signaling pathways.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Hui Tong, Xiaohui Liu, Chenghong Peng, Baiyong Shen, Zhecheng Zhu
Summary: This study demonstrates the significant role of KNTC1 in hepatocellular carcinoma (HCC) development and its correlation with poor prognosis. KNTC1 affects the biological activity of HCC cells through the PI3K/Akt signaling pathway.
CELLULAR SIGNALLING
(2023)
Article
Agriculture, Multidisciplinary
Xiaoya Li, Huali Chen, Zelin Zhang, Dejun Xu, Jiaxin Duan, Xiaodi Li, Li Yang, Rongmao Hua, Jianyong Cheng, Qingwang Li
Summary: Isorhamnetin regulates steroidogenesis in ovarian granulosa cells by activating PI3K/Akt signaling pathway, promoting proliferation, inhibiting apoptosis, and alleviating oxidative stress.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
Article
Cell Biology
Han Dai, Wenjing Hu, Lianying Zhang, Feiyu Jiang, Xiongmin Mao, Gangyi Yang, Ling Li
Summary: Research showed that FGF21 was significantly downregulated in prostate cancer tissues and cell lines, and inhibited PCa cell proliferation and promoted apoptosis through facilitated autophagy.
CELL DEATH & DISEASE
(2021)