Journal
INTEGRATIVE BIOLOGY
Volume 5, Issue 5, Pages 828-834Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3ib20226g
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Funding
- National Research foundation of Korea (NRF)
- Korean government (MEST) [2011-0028845, 2011-0030779]
- Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A120492]
- National Research Foundation of Korea [2011-0030779] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Immunoisolation membranes have been developed for various cell encapsulations for therapeutic purposes. However effective encapsulation systems have been hindered by low oxygen (O-2) permeability or imperfect immunoisolation caused by either low porosity or non-uniform pore geometry. Here, we report an encapsulation method that uses an anodic aluminum oxide membrane formed by polyethylene oxide self-assembly to obtain nanochannels with both high selectivity in excluding immune molecules and high permeability of nutrients such as glucose, insulin, and O-2. The extracorporeal encapsulation system composed of these membranes allows O-2 flux to meet the O-2 demand of pancreatic islets of Langerhans and provides excellent in vitro viability and functionality of islets.
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