Article
Cell & Tissue Engineering
Weiwei Xue, Caixia Fan, Bing Chen, Yannan Zhao, Zhifeng Xiao, Jianwu Dai
Summary: Transplantation of neural stem cells shows promise for restoring communication in spinal cord injury, but the inhibitory microenvironment often leads to glial differentiation rather than neuronal differentiation. Functional biomaterials can mitigate the adverse effects of the SCI microenvironment and promote neuronal differentiation of NSCs.
Article
Cell Biology
Peng Cui, Ping Zhang, Lin Yuan, Li Wang, Xin Guo, Guanghui Cui, Yanmin Zhang, Minghua Li, Xiaowei Zhang, Xiaoqiang Li, Yuxin Yin, Zhendong Yu
Summary: HIF-1α knockdown affects the pluripotency and self-renewal potential of hiPSCs, promoting NSC differentiation and development potential possibly through the MFN2-mediated Wnt/beta-catenin signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Yifan Wang, Tengfei Zhao, Yiren Jiao, Hanxu Huang, Yongxiang Zhang, Ao Fang, Xuhua Wang, Yanling Zhou, Haochen Gu, Qionghua Wu, Jiang Chang, Fangcai Li, Kan Xu
Summary: This study investigates the effect of Laponite nanoplatelets on stem cell therapy. The results show that Laponite nanoplatelets can induce the neuronal differentiation of neural stem cells within five days in vitro, and the NF-kappa B pathway is involved in this process. Moreover, Laponite nanoplatelets can increase the survival rate of transplanted neural stem cells and promote their differentiation into mature neurons. The formation of connections between transplanted cells and host cells is confirmed by axon tracing. Therefore, Laponite nanoplatelets can be considered a convenient and practical biomaterial to enhance the efficacy of neural stem cell transplantation and promote repair of the injured spinal cord.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Medicinal
Hong-He Xiao, Ming-Bo Zhang, Jun-Ting Xu, Yan Deng, Ning Li, Peng Gao, Yan Li, Liang Kong, Wan-yi Li, Ji-Cong Chen, Hong-Yan Li, Guo-Shun Shan, He Tai, Jing-Xian Yang
Summary: Adult neurogenesis is crucial for cognitive function maintenance in mammals and humans, and it is seen as a potential therapeutic strategy for neurodegenerative diseases like Alzheimer's disease. Icarisid II (ICS II), derived from Epimedii Folium, has been shown to have neuroprotective effects, including promoting proliferation and differentiation of neural stem cells (NSCs). The study demonstrates that ICS II promotes NSCs proliferation and neuronal differentiation by activating the Wnt/beta-catenin signaling pathway.
PHYTOTHERAPY RESEARCH
(2021)
Article
Engineering, Biomedical
Jing He, Nihui Zhang, Yue Zhu, Rongrong Jin, Fang Wu
Summary: Integration of neurogenesis into nerve repair materials should consider anti-inflammatory function, using MSC spheroids-loaded collagen hydrogels demonstrated superior anti-inflammatory efficacy and neurogenic activity, modulated by spheroid size. MSC spheroids promoted secretion of trophic factors, ECM, cytokines, and immunomodulatory factors, activating neuroactive ligand-receptor interaction for neuronal differentiation via PI3K-Akt pathway.
Article
Engineering, Biomedical
Fang Han, Xun Ma, Yuanxin Zhai, Leisha Cui, Lingyan Yang, Zhanchi Zhu, Ying Hao, Guosheng Cheng
Summary: A strategy for wireless electrical stimulation of stem cell scaffold using a conductive graphene substrate is reported. The wireless ES enhances neuronal differentiation and neurite formation without affecting the viability and stemness maintenance of neural stem cells, indicating potential for neural regenerative medicine.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Cell & Tissue Engineering
Yi Han Ng, Soham Chanda, Justyna A. Janas, Nan Yang, Yuko Kokubu, Thomas C. Sudhof, Marius Wernig
Summary: Differentiation of pluripotent stem cells can be achieved through signaling pathways activation or transcription factor programming, each with its own advantages and disadvantages. Research findings suggest that specific combinations of transcription factors can efficiently induce the generation of functional dopaminergic neurons.
Review
Biochemistry & Molecular Biology
Mehdi Farokhi, Fatemeh Mottaghitalab, Mohammad Reza Saeb, Shahrokh Shojaei, Negin Khaneh Zarrin, Sabu Thomas, Seeram Ramakrishna
Summary: Currently, there are no clinically available methods to enhance neural structural regeneration and functional recovery of nerve injuries. Conductive materials, such as polypyrrole and graphene, have been considered as one of the best choices for nerve regeneration due to their capacity to control the growth and differentiation of neural stem cells.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Medicine, Research & Experimental
Wei Shan, Liping Zhou, Lizhen Liu, Deju Lin, Qin Yu
Summary: In this study, iPSCs were reprogrammed from somatic cells and differentiated into neurons through induction, with the key role of Bmi1 in the process highlighted.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Michal Arad, Robert A. Brown, Raju Khatri, Rodney J. Taylor, Michal Zalzman
Summary: This study successfully differentiated tonsillar biopsy-derived MSCs into neuron-like cells, providing a potential source for in vitro modeling of neurodegenerative diseases and cell replacement therapies.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Jiewen Chen, Xiaolin Zeng, Wenwu Zhang, Gang Li, Haoming Zhong, Chengzhong Xu, Xiang Li, Tao Lin
Summary: Neural stem cell transplantation has shown potential for promoting spinal cord regeneration in individuals with SCI. Inhibiting Notch signaling can facilitate the differentiation of neural stem cells into neurons. Overexpression of fucosyltransferase 9 (Fut9), regulated by Wnt4, promotes neuronal differentiation by suppressing the activation of Notch signaling. This research provides insight into the mechanisms of Notch signaling and offers a potential treatment strategy for SCI.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Multidisciplinary Sciences
Nidaa A. Ababneh, Ban Al-Kurdi, Fatima Jamali, Abdalla Awidi
Summary: This study compared the differentiation abilities of MSCs isolated from different human tissue sources, and found that WJ-MSCs had a higher potential to differentiate into NSC and dopaminergic-like cells. This could provide an additional or alternative source of cells for neurological cell-based therapies.
Article
Pharmacology & Pharmacy
Xiujuan Ye, Yuanfei Wu, Jiamin Xu, Hui Liu, Huan Wang, Qingfeng Li, Qingqing Li, Aiguo Xuan
Summary: Adult hippocampal neurogenesis is linked to the pathogenesis of neuropsychiatric disorders. The bioactive compound mangiferin (MGF) from mango has been reported to have effects on neuropsychiatric disorders. This study found that MGF enhances neuronal differentiation and proliferation of neural stem cells through PPAR beta, and DNA methylation is negatively correlated with the expression of neurogenesis genes. Further analysis revealed that PPAR beta increases demethylation of the Mash1 promoter by regulating DNA demethylation enzymes. Importantly, genetic deficiency of PPAR beta decreased hippocampal neurogenesis in adult mice, which was rescued by Mash1 overexpression.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Zhenghui He, Lijian Lang, Jiyuan Hui, Yuxiao Ma, Chun Yang, Weiji Weng, Jialin Huang, Xiongfei Zhao, Xiaoqi Zhang, Qian Liang, Jiyao Jiang, Junfeng Feng
Summary: This study found that around 7 days after TBI in mice, the subacute phase could encourage more neuronal differentiation after transplantation. The autophagy flux played a critical role in regulating neuronal differentiation and could be a potential target to improve the efficacy of transplantation in the early phase.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Liumin He, Zhongqing Sun, Jianshuang Li, Rong Zhu, Ben Niu, Ka Long Tam, Qiao Xiao, Jun Li, Wenjun Wang, Chi Ying Tsui, Vincent Wing Hong Lee, Kwok-Fai So, Ying Xu, Seeram Ramakrishna, Qinghua Zhou, Kin Chiu
Summary: Electrical stimulation enhances neural stem cell differentiation into mature neurons by promoting autophagy signaling, which can significantly improve the success rate of neuroregeneration therapy at injured central nervous system sites.