Journal
INSECT MOLECULAR BIOLOGY
Volume 23, Issue 5, Pages 587-597Publisher
WILEY-BLACKWELL
DOI: 10.1111/imb.12107
Keywords
Mthl; lifespan; reproduction; stress resistance; Tribolium castaneum
Categories
Funding
- National Natural Science Foundation of China [31172146]
- Key Project of Natural Science Foundation of the Jiangsu Higher Education Institutions of China [10KJA180023]
- Natural Science Foundation of Jiangsu Province, China [BK2011785]
- PAPD of Jiangsu Higher Education Institutions
- Excellent Talent Project of Nanjing Normal University of China
- graduate innovation research projects of Jiangsu Colleges and Universities [CXZZ11_0884, CXZZ13_0412]
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Methuselah (Mth) is associated with lifespan, stress resistance and reproduction in Drosophila melanogaster, but Mth is not present in nondrosophiline insects. A number of methuselah-likes (mthls) have been identified in nondrosophiline insects, but it is unknown whether the functions of mth are shared by mthls or are divergent from them. Five mthls have been identified in Tribolium castaneum. Although they have different developmental expression patterns, they all enhance resistance to starvation. Only mthl1 and mthl2 enhance resistance to high temperature, whereas mthl4 and mthl5 negatively regulate oxidative stress in T. castaneum. Unlike in the fly with mth mutation, knockdown of mthls, except mthl3, shortens the lifespan of T. castaneum. Moreover, mthl1 and mthl2 are critical for Tribolium development. mthl1 plays important roles in larval and pupal development and adult eclosion, while mthl2 is required for eclosion. Moreover, mthl1 and mthl2 silencing reduces the fertility of T. castaneum, and mthl1 and mthl4 are also essential for embryo development. In conclusion, mthls have a significant effect on insect development, lifespan, stress resistance and reproduction. These results provide experimental evidence for functional divergence among mthls/mth and clues for the signal transduction of Mthls.
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