Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Article
Integrative & Complementary Medicine
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue, Lihong Fan
Summary: Amygdalin induces apoptosis of lung cancer cells through multiple mechanisms, including altered expression of apoptosis-related proteins, activation of NF kappa B-1 gene, and inhibition of NF kappa B signaling cascade. These findings reveal the potential of amygdalin as a therapeutic agent for lung cancer.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Immunology
Shouye Hu, Yanqi Li, Bo Wang, Kan Peng
Summary: The study showed that TRIM38 can alleviate IL-1 beta-induced apoptosis and degeneration of chondrocytes by suppressing the NF-kappa B signaling pathway. This work suggests a potential role of TRIM38 in osteoarthritis and proposes it as a new therapeutic target for the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Su-Jin Lee, Da-Eun Lee, Soo-Young Choi, Oh-Shin Kwon
Summary: Levels of OGT and hyper-O-GlcNAcylation are associated with cancer pathogenesis, and combining OGT inhibitor OSMI-1 with TRAIL shows a synergistic effect in inducing apoptosis in cancer cells by increasing DR5 expression and activating ER stress response. This combination treatment inhibits NF-kappa B signaling, leading to enhanced TRAIL-induced apoptosis through caspase-8 activation in HCT116 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huiyuan Zhu, Qianyu Li, Qiongyi Huang, Huiqiong Yang, Jiayi Zheng, Ruting Xie, Dongyan Han, Qing Wei
Summary: RIG-I plays a crucial role in promoting epithelial keratinocyte proliferation and wound repair by inducing TIMP-1 expression via the NF-κB signaling pathway. TIMP-1 directly accelerates keratinocyte proliferation and promotes wound healing, making RIG-I a potential biomarker for assessing skin injury severity and a therapeutic target for chronic wounds such as diabetic foot.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maria Feoktistova, Roman Makarov, Amir S. Yazdi, Diana Panayotova-Dimitrova
Summary: TNF-induced cell death is regulated by RIPK1 and TRADD, with RIPK1 playing a critical role in apoptosis and necroptosis in the absence of IAPs, while TRADD functions as a negative regulator of NIK stabilization and ripoptosome formation. Additionally, MAPK signaling activation does not require RIPK1 and TRADD, and partial repression of NF-kappa B activation in these cells does not sensitize them to TNF due to the lack of NIK stabilization. RIPK1 is essential for preventing TRADD ubiquitination and degradation during TNF signaling, highlighting the intricate balance between cell death and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qi Wu, Xiaoqing Zhou, Peng Li, Mao Ding, Shengjie You, Zhaoyu Xu, Junjie Ye, Xuedong Chen, Mingyue Tan, Jun Wang, Wei Wang, Jianxin Qiu
Summary: ROC1 is up-regulated in BCa tissues and cell lines, with high levels correlated with higher tumor grade, metastasis, and poor prognosis. It promotes BCa invasion and migration by activating NF-κB signaling through enhancing p-IκBα ubiquitination, leading to p65 nuclear translocation and transcription of metastasis-related genes.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shifaa M. Abdin, Mai F. Tolba, Dana M. Zaher, Hany A. Omar
Summary: The inhibition of NF-kappa B activity can enhance the sensitivity of breast cancer cells to chemotherapy, particularly doxorubicin, by modulating multidrug resistance. Combined treatment with NF-kappa B inhibitors can sensitize resistant breast cancer cells to doxorubicin, by suppressing NF-kappa B activation and downregulating MDR efflux transporters.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Editorial Material
Microbiology
Robert Z. Zhang, Melissa Kane
Summary: HIV-1 both inhibits and activates the NF-kappa B pathway, which is important for the viral life cycle. The viral protein U has contrasting effects on beta-TrCP1 and beta-TrCP2, leading to dysregulation of the NF-kappa B pathways. These findings enhance our understanding of how the NF-kappa B pathway functions during viral infection.
Article
Medicine, Research & Experimental
Fatma F. Ali, Sahar A. Mokhemer, Doaa M. Elroby Ali
Summary: Hemin can protect the ovaries from ischemia reperfusion injury by increasing the expression of HO-1, which has antioxidant, anti-inflammatory, and anti-apoptotic effects.
Article
Immunology
Mahmoud Darweesh, Shady Younis, Zamaneh Hajikhezri, Arwa Ali, Chuan Jin, Tanel Punga, Soham Gupta, Magnus Essand, Leif Andersson, Goran Akusjarvi
Summary: ZC3H11A protein is involved in the regulation of NF-κB signaling pathway, and its depletion leads to enhanced signaling and accumulation defects of IκBα mRNA and protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yang Lyu, Bowen Duan, Ziming Liu, Fan Yang, Chen Chen, Xuejiao Jiang, Xiang Liu
Summary: This study found that Sparstolonin B inhibits the growth and induces apoptosis of pancreatic cancer cells through the NFxB signaling pathway, making it a potential novel drug for pancreatic cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qiang Gu, Ying-Bin Xiao, Yong Wang
Summary: In hypoxic cardiomyocytes, silencing of SOCS3 induces apoptosis of H9c2 cells by regulating apoptosis-associated gene expression, possibly through activation of the p-STAT3/NF-kappa B signaling pathway under hypoxic conditions.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang, Duwen Zhang
Summary: Bupivacaine inhibits colorectal cancer proliferation by suppressing cell viability, promoting apoptosis and autophagy, regulating the NF-kappa B signaling pathway, demonstrating potential therapeutic effects.
Article
Medicine, Research & Experimental
Ting Zhao, Jianming Zeng, Yujie Xu, Zhongping Su, Yulong Chong, Tao Ling, Haozhe Xu, Hui Shi, Minggao Zhu, Qi Mo, Xiaoying Huang, Yingchang Li, Xiaoren Zhang, Hongbin Ni, Qiang You
Summary: This study reveals that CHI3L1 is overexpressed in glioma and plays a crucial role in tumor progression. It enhances the NF-kappa B signaling pathway and interacts with ACTN4 and NFKB1. Additionally, CHI3L1 reprograms the tumor microenvironment and contributes to M2 macrophage polarization. It is also positively correlated with the expression of immune checkpoints and remodels the TME to an immunosuppressive phenotype.