Journal
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 41, Issue 10, Pages 788-794Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ibmb.2011.05.009
Keywords
Ethyl 4-(2-benzylhexyloxy)benzoate; Juvenile hormone biosynthetic enzymes; Anti-juvenile hormone; Bombyx mori; Corpora allata
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Funding
- Program for Promotion of Basic Research Activities (PROBRAIN)
- Japanese Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [22380032] Funding Source: KAKEN
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Ethyl 4-[(S)-2-benzylhexyloxy)lbenzoate (KF-13S), derived from ethyl 4-[2-(tert-butylcarbonyloxy) butoxy]benzoate (ETB), has strong anti-juvenile hormone OH) activity which causes precocious metamorphosis in Bombyx mori. and the mode of action of this compound was studied. Application of KF-13S inhibited JH biosynthesis by the corpora allata (CA) in a reversible manner, and in vitro culture experiments showed that this inhibition was due to the direct action of this compound on the CA. When mRNA expression of the JH biosynthetic enzymes were studied, KF-13S strongly suppressed those of HMG Co-A synthase and HMG Co-A reductase. mRNA levels of other mevalonate enzymes and JH acid O-methyltransferase were also suppressed but were less sensitive to the compound. These studies showed that KF-13S prevents the transcription of many of the JH biosynthetic enzymes so that JH synthesis is suppressed. (C) 2011 Elsevier Ltd. All rights reserved.
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