Journal
INORGANICA CHIMICA ACTA
Volume 394, Issue -, Pages 65-76Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2012.07.018
Keywords
Platinum dicarboxylate compounds; DNA binding; Atomic force microscopy; Platinum drugs
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Funding
- Spanish Ministry of Ciencia e Innovacion [CTQ2008-02064, BIO2010-22321-C02-01]
- University of Barcelona
- ICREA Funding Source: Custom
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A series of platinum(II) complexes of formulae cis-[Pt(Am)(2)X-2] (where Am represents an inert amine and X a labile (carboxylato) ligand) have been prepared and characterized by elemental analysis, ESI-MS, IR and H-1 NMR spectroscopy. The single-crystal molecular structures were determined for cis-[Pt(opea)(cbdca-2H)], cis-[Pt(hmpy)(cbdca-2H)], cis-[Pt(NH3)(2)(bzmal-2H)] and cis-[Pt(hmpy)(mu-dcch-2H)(2)] (where opea is picolylamine, hmpy represents 4-hydroxymethylpyridine, cbdca-2H, is 1,1-cyclobutanedicarboxylate anion, bzmal-2H stands for benzylmalonate anion and dcch-2H is trans-1,2-cyclohexanedicarboxylate anion). The interaction of all compounds with DNA was investigated with different techniques: viscosity measurements and emission fluorescence spectroscopy were used to investigate the changes induced by the binding of the platinum compounds to calf-thymus DNA, while atomic force microscopy and electrophoretic mobility allowed evaluating the potential alterations of pBR322 plasmid DNA. The cytotoxic behavior of the platinum compounds on human leukemia HL-60 tumor cell lines was also examined. (C) 2012 Elsevier B. V. All rights reserved.
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