The reactivity of NbX5 (X = F, Cl) with lactons, lactams, and the synthesis of the first nucleobase-containing niobium complex

NbX5 (X = F, 1a; X = Cl, 1b) reacted with gamma-butyrolactone (but), epsilon-caprolactam (cap), delta-valerolactam (val) in 1:1 M ratio in chlorinated solvent, affording either the neutral coordination adducts NbCl5L (L = but, 2a; L = val, 2b) or the ionic ones [NbX4L2][NbX6] (X = F, L = but, 3a; X = F, L = val, 3b; X = F, L = cap, 3c; X = Cl, L = cap, 3d). The reaction of 1a with equimolar amount of guanine (gua) in CH3CN resulted in the formation of the complex [NbF4(gua)(2)][NbF6], 3e. The addition of two equivalents of organic substrate to 1 gave selectively the compounds NbCl5L2 (L = but, 4a; L = val, 4b) or [NbF4L4][NbF6] (L = but, 5a; L = val, 5b; L = cap, 5c). The 1: 2 M reaction of 1b with e-caprolactam proceeded with C-N bond activation and afforded the derivative [NbCl4(cap)(NH(CH2)(5)C(O)OC(CH2)(5)NH][NbCl6], 6, in high yield. (C) 2011 Elsevier B.V. All rights reserved.