Journal
MEDICAL IMAGE ANALYSIS
Volume 26, Issue 1, Pages 195-202Publisher
ELSEVIER
DOI: 10.1016/j.media.2015.08.001
Keywords
Chest CT; Peri-fissural nodules; Lung cancer screening; Convolutional neural networks; OverFeat; Deep learning
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Funding
- Netherlands Organization for Scientific Research [639.023.207]
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In this paper, we tackle the problem of automatic classification of pulmonary peri-fissural nodules (PFNs). The classification problem is formulated as a machine learning approach, where detected nodule candidates are classified as PFNs or non-PFNs. Supervised learning is used, where a classifier is trained to label the detected nodule. The classification of the nodule in 3D is formulated as an ensemble of classifiers trained to recognize PFNs based on 2D views of the nodule. In order to describe nodule morphology in 2D views, we use the output of a pre-trained convolutional neural network known as OverFeat. We compare our approach with a recently presented descriptor of pulmonary nodule morphology, namely Bag of Frequencies, and illustrate the advantages offered by the two strategies, achieving performance of AUC = 0.868, which is close to the one of human experts. (C) 2015 Elsevier B.V. All rights reserved.
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