Review
Medicine, General & Internal
Anna Louise Pouncey, Mark Woodward
Summary: Cardiovascular disease is the leading cause of death in women, with ischaemic heart disease, stroke, and peripheral arterial disease being major components. However, there is a lack of knowledge about the risk factors and efficacy of treatment in women, resulting in reduced opportunities for prevention and management.
Article
Public, Environmental & Occupational Health
Jeremy R. Van't Hof, Wendy Wang, Kunihiro Matsushita, Gerardo Heiss, Aaron R. Folsom, Rachel Widome, Pamela L. Lutsey
Summary: The study aimed to investigate the association between smokeless tobacco use and the risk of developing peripheral artery disease. The results showed that current smokeless tobacco use was associated with a higher risk of peripheral artery disease, similar to cigarette smoking. The importance rating of this study is 8 out of 10.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Matthew Nayor, Kemar J. Brown, Ramachandran S. Vasan
Summary: The development of atherosclerotic cardiovascular disease can be tracked through molecular signatures and imaging methods, providing personalized risk assessment.
CIRCULATION RESEARCH
(2021)
Review
Peripheral Vascular Disease
Yeonyee E. Yoon, Bo La Yun, Kyoung Min Kim, Jung-Won Suh
Summary: BAC has emerged as a potential women-specific risk marker for ASCVD, showing a correlation with ASCVD risk factors or subclinical and clinical ASCVD. The potential clinical application of BAC in enhancing ASCVD risk estimation, without additional cost or radiation, is appealing. Further research is needed for optimal risk assessment and management in women with BAC, but its presence should prompt healthy cardiovascular lifestyle modifications.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Nestor Vasquez, Colby R. Ayers, Jaideep Patel, Ananya Hooda, Amit Khera, Roger S. Blumenthal, Michael D. Shapiro, Carlos J. Rodriguez, Michael Y. Tsai, Laurence S. Sperling, Salim S. Virani, Michael J. Blaha, Parag H. Joshi
Summary: Elevated lipoprotein(a) and coronary artery calcium are independently associated with ASCVD risk, and may be concurrently useful in guiding primary prevention therapy decisions, as demonstrated in the MESA and DHS cohorts.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard
Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Stanislaw Surma, Maciej Banach
Summary: Atherosclerotic cardiovascular diseases (ASCVD) are a major cause of premature death worldwide. Biomarkers that can detect and assess the prognosis of ASCVD are highly sought after. Fibrinogen, a protein that increases in concentration in ASCVD patients, may serve as a biomarker for the disease and contribute to its development through genetic polymorphisms and post-translational modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hung-Ju Ko, Chuan-Chuan Liu, Po-Jui Hsu, Kuang-Chun Hu, Chung-Lieh Hung, Lo-Yip Yu, Yun-Chieh Huang, Shou-Chuan Shih
Summary: This study compared the role of baPWV with other risk indicators in identifying subclinical vascular disease and found that baPWV has clinical utility in improving prognosis for high-risk subjects.
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Paul A. Brown, Paul D. Brown
Summary: Atherogenesis is a complex process involving chronic inflammation and the participation of various cell types and molecules. Extracellular vesicles play a crucial role in this process, contributing to monocyte transmigration, foam cell formation, smooth muscle cell proliferation and migration, leukocyte transmigration, and thrombosis. Peripheral arterial disease, a common type of peripheral vascular disease, is characterized by impaired blood supply due to atherosclerosis. Elevated levels of extracellular vesicles have been found in patients with peripheral arterial disease and are implicated in the development of atherosclerosis. However, extracellular vesicles also have the potential to deliver cargo with atheroprotective effects, offering opportunities for therapeutic angiogenesis in the management of peripheral arterial disease.
CARDIOVASCULAR PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miguel Cainzos-Achirica, Renato Quispe, Ramzi Dudum, Philip Greenland, Donald Lloyd-Jones, Jamal S. Rana, Joao A. C. Lima, Henrique Doria de Vasconcellos, Parag H. Joshi, Amit Khera, Colby Ayers, Raimund Erbel, Andreas Stang, Karl-Heinz Joeckel, Nils Lehmann, Sara Schramm, Borge Schmidt, Peter P. Toth, Kershaw Patel, Michael J. Blaha, Marcio Bittencourt, Khurram Nasir
Summary: This study evaluates whether the coronary artery calcium (CAC) score can enhance risk stratification for individuals with hypertriglyceridemia and the applicability of Icosapent ethyl (IPE) eligibility criteria.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sing Ching Lee, Sarah Pirikahu, Lin Fritschi, Terry Boyle, Carl Schultz, Elizabeth Wylie, Jennifer Stone
Summary: This study examines the association between breast arterial calcification (BAC) and atherosclerotic cardiovascular disease (ASCVD) within an Australian population-based breast cancer study. The findings suggest that BAC is associated with ASCVD risk, but this association is not independent of other cardiovascular risk factors.
Review
Cardiac & Cardiovascular Systems
Sergio Jansen-Chaparro, Maria D. Lopez-Carmona, Lidia Cobos-Palacios, Jaime Sanz-Canovas, M. Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
Summary: PAD is a common atherosclerotic condition that can lead to decreased quality of life and increased risk of cardiac or cerebrovascular events. Statins are recommended for reducing cardiovascular events and mortality in PAD patients, but the prescribing rate is lower than in patients with coronary heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Clemence Bechelli, Diane Macabrey, Sebastien Deglise, Florent Allagnat
Summary: Peripheral artery disease (PAD) affects a significant number of individuals worldwide and has detrimental effects on quality of life and overall health. Unfortunately, PAD is often overlooked and not adequately treated compared to other cardiovascular conditions. PAD is a complex disease involving arterial atherosclerosis, calcification, and microvascular abnormalities, resulting in chronic ischemia. Novel therapies such as hydrogen sulfide show promise in mitigating the destructive effects of PAD by providing vasorelaxant, cytoprotective, and anti-inflammatory properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jiayi Yi, Lili Wang, Xinli Guo, Xiangpeng Ren
Summary: This study analyzed data from seven community-based prospective cohort studies to investigate the influence of historical cardiovascular risk status on future risk of atherosclerotic cardiovascular disease (ASCVD). The results showed that individuals with different historical cardiovascular disease (CVD) risks but the same current CVD risk status exhibited varying risks of future ASCVD incidents. Therefore, incorporating historical risk status into cardiovascular risk stratification can enable more accurate risk evaluation and inform decision-making regarding preventive interventions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Physiology
Matthew D. Muller, Tariq Ali Ahmad, Alvaro F. Vargas Pelaez, David N. Proctor, Anthony S. Bonavia, J. Carter Luck, Stephan R. Maman, Amanda J. Ross, Urs A. Leuenberger, Patrick M. McQuillan
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Physiology
Stephan R. Maman, Alvaro F. Vargas, Tariq Ali Ahmad, Amanda J. Miller, Zhaohui Gao, Urs A. Leuenberger, David N. Proctor, Matthew D. Muller
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Editorial Material
Cardiac & Cardiovascular Systems
Tariq Ali Ahmad, Ian C. Gilchrist
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Tariq Ali Ahmad, Ian C. Gilchrist
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
Tariq Ali Ahmad, Soraya Samii, John Boehmer, Abdul Basit
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Tariq Ali Ahmad, Ryan Wilson, Jovan Plamenac, Sumeet Lall, Brent Dembo, James Kogut, Chad Zack
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
James Kogut, Brent Dembo, Jovan Plamenac, Sumeet Lall, Ryan Wilson, Tariq Ali Ahmad, Chad Zack
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brent Dembo, James Kogut, Sumeet Lall, Tariq Ahmad, Ryan Wilson, Chad Zack
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sumeet Lall, Ryan Wilson, Tariq Ali Ahmad, Brent Dembo, James Kogut, Jovan Plamenac, Chad Zack
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Meeting Abstract
Cardiac & Cardiovascular Systems
Brent Dembo, James Kogut, Ryan Wilson, Sumeet Lall, Tariq Ahmad, Chad Zack
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Clinical Neurology
Arshjot Khokhar, Athira Nair, Vishal Midya, Ashutosh Kumar, Ankita Sinharoy, Tariq Ali Ahmad, Mutasim Abu-Hasan, Pritish Mondal
Meeting Abstract
Cardiac & Cardiovascular Systems
Tariq Ali Ahmad, Mohammed Ruzieh, Guodong Liu, Douglas Leslie, Cynthia Chuang, Andrew Foy
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Physiology
Alvaro F. Vargas Pelaez, Zhaohui Gao, Tariq A. Ahmad, Urs A. Leuenberger, David N. Proctor, Stephan R. Maman, Matthew D. Muller
PHYSIOLOGICAL REPORTS
(2016)
Article
Cardiac & Cardiovascular Systems
Tariq A. Ahmad, Matthew Nudy, Dirk Pabst, Mark Kozak
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2018)
Article
Medicine, General & Internal
Jeanne E. Conner, Joshua A. Steinberg
Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Alejandra Escobar Vasco, Julie -Ann Talano, Larisa Broglie
Summary: HLH is a rare but fatal disease, and maintaining a high level of suspicion is crucial for patients with evidence of hyperinflammation. Adolescents with HLH should undergo genetic evaluation for familial HLH, and primary immune deficiencies and dysregulation disorders should also be considered. Early diagnosis and treatment are necessary to prevent morbidity and mortality related to HLH's hyperinflammation.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kathleen Ryan
Summary: Fevers of unknown origin (FUO) present a diagnostic challenge, with a wide range of potential causes including infectious, autoimmune, and malignant. Some adolescents with FUO may never have an identifiable etiology, but the prognosis is generally favorable in the absence of red flag symptoms.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Brett J. Bordini, Ryan D. Walsh, Donald Basel, Tejaswini Deshmukh
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Hsi Yen, Leah Lalor
Summary: The article emphasizes the importance of increased awareness among healthcare providers when faced with severe adolescent acne that may not be typical teenage acne. It provides a summary of uncommon causes of severe adolescent acne and a simplified diagnostic approach. Additionally, it discusses rare autoinflammatory syndromic causes of acne and acne associated with excess androgen states.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bethany Auble, Justin Dey
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kaitlin V. Kirkpatrick, James J. Nocton
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Louella Amos
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Tracey Thompson, Ashley Phimister, Alexander Raskin
Summary: Heart failure occurs as a result of pressure or volume overload in congenital and acquired heart diseases, and its treatment varies depending on the underlying cause.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Allison Remiker, Kristina Bolling, James Verbsky
Summary: CVID is a heterogeneous group of disorders characterized by abnormal B-cell differentiation and impaired production of specific immunoglobulin. Clinical manifestations vary and include recurrent bacterial infections, lymphoproliferation, autoimmunity, pulmonary disease, gastrointestinal disease, granulomas, and increased cancer risk. The diagnosis of CVID is complex, requiring exclusion of other causes of immunoglobulin deficiency and assessment based on clinical criteria models. Treatment involves regular immunoglobulin replacement therapy, infection prevention, and surveillance for complications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Vaishali Singh, Scott K. Van Why
Summary: Hypertension in adolescents is rare, and evaluation for identifiable causes beyond primary hypertension is necessary. Common causes of hypertension in this age group are usually acquired or congenital renal or vascular diseases. If these etiologies are not found, exploration for rare causes, including monogenic hypertension, should be pursued.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Dominic O. Co
Summary: Acquired demyelinating syndromes (ADS) are a group of inflammatory demyelinating conditions that include optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Differentiating between subtypes of ADS is important for optimal patient management, and this can be achieved by considering clinical features, laboratory tests (especially autoantibodies), and MRI findings.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Meghan K. Konda, Matthew Harmelink
Summary: Pediatric adolescent muscle weakness can have various causes. A methodical diagnostic evaluation is necessary to determine the specific disease category, which may require specialized care or extensive testing. The ultimate diagnosis is crucial for prognostication.
MEDICAL CLINICS OF NORTH AMERICA
(2024)