Journal
INNATE IMMUNITY
Volume 18, Issue 1, Pages 70-79Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425910393369
Keywords
Endotoxin; liver injury; nuclear factor kappa B (NF-kappa B); polyphenols; tumor necrosis factor alpha (TNF-alpha)
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Funding
- Indian Council of Medical Research (ICMR), New Delhi, India
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Activation of NF-kappa B has been reported to play a key role in causing endotoxin-induced hepatic damage through enhanced production of reactive oxygen species and pro-inflammatory mediators. In this context, the potential of polyphenolic phytochemicals in preventing endotoxin-induced liver damage remains unclear. Here, we demonstrate that catechin and quercetin have the potential to down-regulate the initial signalling molecule NF-kappa B which may further inhibit the downstream cascade including TNF-alpha and NO. These results were confirmed using N-nitro-L-arginine methyl ester (L-NAME), the inhibitor of inducible nitric oxide synthase (iNOS) along with the biochemical and histological alterations occurring in the presence and absence of supplementation with both the polyphenols. However, catechin was found to be more effective than quercetin against endotoxin-induced liver injury. These findings suggest that these polyphenols may form a pharmacological basis for designing a therapeutic agent against endotoxin-mediated oxidative damage.
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