Article
Biochemistry & Molecular Biology
Francesco De Francesco, Pasquale Gravina, Stefano Varagona, Stefania Setti, Antonio Gigante, Michele Riccio
Summary: This study found that administration of biophysical stimulation promotes fracture healing and improves the union rate compared to non-treatment. Patients who received biophysical stimulation experienced less distress during the fracture and repair period, resulting in reduced immobilization time and better patient hand outcomes.
Article
Surgery
Amirreza Sadeghifar, Mohamad Sheibani, Siyavash Joukar, Shahriar Dabiri, Samanehsadat Alavi, Omid Azari, Darioush Vosoghi, Yas Zeynali, Yasman Zeynali, Mohamad Shahraki, Amirhesam Torghabe, Farzaneh Rostamzadeh, Alireza Nasri
Summary: The study found that rats exposed to waterpipe tobacco smoking experienced disturbance and delay in femoral fracture healing, partly due to reduced molecular stimuli for bone synthesis and attenuation of quantitative angiogenesis.
FRONTIERS IN SURGERY
(2021)
Article
Physiology
Shaolong Zhou, Lingling Wan, Xu Liu, Delin Hu, Feng Lu, Xihang Chen, Fangguo Liang
Summary: Diabetes delays wound healing and impairs function of Schwann cells (SCs) in the peripheral nervous system. SCs in diabetic mice are dysfunctional and fail to rapidly activate a repair program after skin wound injury. Additionally, high glucose conditions impair SC function and affect the paracrine effects of SCs on myofibroblast formation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Orthopedics
Gabriele Gariffo, Vanna Bottai, Federico Falcinelli, Federico Di Sacco, Roberta Cifali, Elisa Troiano, Rodolfo Capanna, Nicola Mondanelli, Stefano Giannotti
Summary: This study evaluated the use of Teriparatide in conjunction with appropriate surgical procedures for the treatment of delayed bone healing and nonunions. The results suggest that Teriparatide may play an important role in treating certain forms of delayed unions or nonunions, particularly when combined with a condition in which the bone is in an active phase of collagen synthesis or a revitalizing treatment. Further studies are needed to confirm the efficacy of the drug.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Immunology
Siqi Liu, Junfu Guo, Xianda Cheng, Wenna Li, Shuangyu Lyu, Xuanyi Chen, Qingwei Li, Hao Wang
Summary: This study identifies TGF-beta homologs in jawless vertebrates and reveals the origin and evolution of the TGF-beta subfamily. The findings suggest that TGF-beta s play important roles in immune regulation in vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Akanksha Mahajan, Narinder Kumar, Bhawna Gupta
Summary: Smoking is associated with an increased risk of non-union, delayed union, and prolonged time to union in tibial shaft fractures. The review highlights the detrimental impact of smoking on healing and emphasizes the importance of smoking cessation in patient education.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biology
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele
Summary: Amino-terminal fragments of proteolytically cleaved GSDMs form plasma membrane pores, leading to pyroptosis. GSDMD and GSDME play roles in bone microenvironment and contribute to fracture healing. Both GSDMD and GSDME regulate inflammatory responses through the GSDM-IL-1 axis, promoting bone healing after fracture.
Article
Biochemistry & Molecular Biology
Yun-Lung Chung, Pei-Yu Chou, Ming-Jyh Sheu
Summary: This study evaluated the wound-healing activity of PEDOT: PSS and found that it significantly improved wound healing in SD rats. The treatment increased angiogenic behavior and VEGF expression, indicating its angiogenic effects. The results suggest that PEDOT: PSS can be potentially used as a dressing for medical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Debora Denardin Luckemeyer, Wenrui Xie, Arthur Silveira Prudente, Katherine A. Qualls, Raquel Tonello, Judith A. Strong, Temugin Berta, Jun-Ming Zhang
Summary: Through experiments, researchers found that the TGF-beta signaling pathway plays an important role in local sympathetic blockade by regulating macrophages in the DRG and its anti-inflammatory actions to alleviate pain behaviors.
NEUROSCIENCE BULLETIN
(2023)
Review
Endocrinology & Metabolism
Larisa Ryskalin, Federica Fulceri, Gabriele Morucci, Stefania Dell'Agli, Paola Soldani, Marco Gesi
Summary: Compared to other long bones, forearm fractures are challenging to treat due to their high rate of complications. Surgical procedures are considered the standard treatment, but extracorporeal shockwave therapy (ESWT) is emerging as a less invasive and effective alternative. This article reports a successful case of ESWT treatment for delayed bone healing in the forearm, providing valuable information for the use of ESWT in forearm fractures.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Xiao Feng, Wei Feng, Yu Ji, Tingting Jin, Jingyu Li, Jincai Guo
Summary: This study investigates the relationship between TGF-beta 1 and SOCS7 in the re-epithelialization of keratinocytes during skin wound healing. The results show that TGF-beta 1 downregulates SOCS7 expression and overexpression of SOCS7 suppresses TGF-beta 1-induced keratinocyte migration. TGF-beta 1 negatively regulates SOCS7 through the binding of EGR1 to the SOCS7 promoter. This study identifies the TGF-beta 1/EGR1/SOCS7 pathway as a potential therapeutic target for promoting wound healing.
CELL COMMUNICATION AND SIGNALING
(2022)
Review
Oncology
Franziska Lioba Breulmann, Luan Phelipe Hatt, Boris Schmitz, Esther Wehrle, Robert Geoff Richards, Elena Della Bella, Martin James Stoddart
Summary: This systematic review aimed to identify common miRNAs involved in fracture healing or non-union fractures. Out of 151 miRNAs, miR-21, miR-140 and miR-214 were the most investigated miRNAs in fracture healing in general, while miR-31-5p, miR-221 and miR-451-5p were identified to be regulated specifically in non-union fractures. Despite heterogeneity between studies, these miRNAs have the potential to serve as biomarkers for non-union fractures.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Materials Science, Biomaterials
Chen Zhang, Dan Yang, Tai-Bao Wang, Xuan Nie, Guang Chen, Long-Hai Wang, Ye-Zi You, Qin Wang
Summary: In this study, a biodegradable hydrogel loaded with verteporfin was developed. The hydrogel could effectively treat infected wounds, accelerate healing, and regulate the extracellular matrix. It showed potential for scar healing in infected wounds due to its anti-scarring and antibacterial properties.
BIOMATERIALS SCIENCE
(2022)
Article
Cell & Tissue Engineering
J. Sung, K. R. Barratt, S. M. Pederson, C. Chenu, I. Reichert, G. J. Atkins, P. H. Anderson, P. J. Smitham
Summary: This study found that impaired fracture healing in patients with type 2 diabetes mellitus (T2DM) may be due to elevated or prolonged inflammation. Gene expression analysis revealed several upregulated genes associated with inflammation in the fracture callus of T2DM rats. These identified genes may serve as biomarkers for monitoring and treating delayed fracture healing in diabetic patients.
BONE & JOINT RESEARCH
(2023)
Article
Medicine, General & Internal
Christina Degenhart, Lucas Engelhardt, Frank Niemeyer, Felix Erne, Benedikt Braun, Florian Gebhard, Konrad Schuetze
Summary: This pilot study aimed to predict fracture healing using a numerical simulation model, which showed promising results in accurately assessing the healing process and providing individualized prognosis for fracture patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Andrija Jurina, Valentina Delimar, Zlatko Giljevic, Tajana Filipec Kanizaj, Andro Matkovic, Dinko Vidovic, Nikolina Jurjevic, Vinko Vidjak, Zeljko Duic, Mario Cuk, Mladen Japjec, Tomislav Dujmovic, Andrea Radeljak, Mirjana Marjana Kardum Paro, Marijana Vucic-Lovrencic, Mario Staresinic
Summary: This study investigated the prevalence of fragility spinal fractures among liver transplant candidates with cirrhosis. The results showed the detrimental impact of chronic liver disease and hepatic osteodystrophy on bone strength, and the correlation between DXA measurement and lumbar fragility fractures. These findings highlight the importance of adequate bone evaluation in liver transplant candidates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Jacob Hartline, Christopher T. Cosgrove, Nathan N. O'Hara, Qasim M. Ghulam, Zachary D. Hannan, Robert V. O'Toole, Marcus F. Sciadini, Christopher G. Langhammer
Summary: In a young, healthy orthopedic trauma population with isolated extremity injury, traditional demographic factors and ballistic injury mechanism have a greater predictive value for long-term mortality after hospital discharge compared to popular markers of socioeconomic status.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Youngmin Kwon, Jihye Lim, Chunui Lee
Summary: This study aims to investigate dental traumatic injuries related to standing electric scooters and compare them with injuries caused by other factors. The results indicate that crown-root fractures and avulsions are more common in electric scooter accidents. Additionally, relatively minor dental injuries, such as concussions and subluxations, are more likely to occur as combined injuries in electric scooter accidents. The study suggests the need for strengthened policies and enforcement of laws to prevent severe dental and craniofacial trauma associated with electric scooter use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
Summary: This study describes the histopathology of debrided bone tissue in chronic osteomyelitis (CO). The inflammatory response still exists after debridement, although it fades from the center. Sampling of debrided bone tissue must be performed initially during surgery to avoid underestimation of neutrophil infiltration.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Alejandro Alejandrez, Motasem Refaat, Yeng Vue
Summary: This study aims to assess the rate of operative fixation of sacral fractures in pelvises with dysmorphic and nondysmorphic sacrums, as well as whether a difference exists in fracture morphology between groups. The study found no statistical difference in operative fixation rates between pelvises with dysmorphic and nondysmorphic sacrums, but a difference in fracture patterns was observed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Dong Wang, Shuo Diao, Xiaobin Zhou, Junlin Zhou, Yang Liu
Summary: This study discussed the role of fracture site tissue exosomes lncRNAs-mRNAs networks on post-injury adaptation (PIA) promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. The results confirmed that PIA accelerated BMSCs proliferation and migration, and identified tissue exosomes as the key factor in this process. By analyzing the tissue exosomes lncRNAs-mRNAs networks, several hub genes, such as Akt1, Actb, and Uba52, were identified, and Kif11 was found to be a key gene in BMSCs regulated by tissue-derived exosomes of PIA treated rats.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Lisa Reider, Jason R. Falvey, Safiyyah M. Okoye, Jennifer L. Wolff, Joseph F. Levy
Summary: Falls are a leading cause of injury and hospital readmissions in older adults, with over 3 million seeking hospital care for fall injuries annually in the United States. The annual acute treatment costs for these injuries amount to $20 billion, indicating the urgent need for evidence-based fall prevention interventions and investments in geriatric emergency departments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Mohamed Elbuzidi, Alyssa N. Wenzel, Andrew Harris, Majd Marrache, Julius K. Oni, Harpal S. Khanuja, Vishal Hegde
Summary: A retrospective propensity score matched cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to compare outcomes for patients with recently diagnosed COVID-19 infection and those without COVID-19 infection undergoing operative treatment of hip fractures. The results showed that COVID-19-positive patients had a higher risk of 30-day mortality, pneumonia, unplanned intubation, septic shock, longer length of hospital stay, and discharge to an acute care hospital. Active COVID-19 infection is an independent risk factor for complications and increased resource utilization in these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Jorge Mayor, Vera Birgel, Jan-Dierk Clausen, Goekmen Aktas, Stephan Sehmisch, Ann-Kathrin Einfeldt, Vasilis Giannoudis, Ahmed H. K. Abdelaal, Emmanouil Liodakis
Summary: This study provides a comprehensive overview of biomechanical research on the treatment of intertrochanteric fractures using cephalomedullary devices. Through a systematic literature search and synthesis analysis, the study highlights the need for standardization in biomechanical studies, and suggests strategies to enhance construct stability. The findings emphasize the importance of further research and meta-analyses to establish standardized protocols and enhance reliability.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Zhiyi Liu, Guodong Hou, Wencong Zhang, Junyan Lin, Jinrong Yin, Huan Chen, Guowei Huang, Aiguo Li
Summary: Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by intense contraction of the gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). The risk of injuries to the skin and Achilles tendon around the calcaneal tuberosity is closely related to the Lee classification and Carnero-Martin de Soto Classification of this type of fracture. Diagnosis is typically confirmed through X-ray, digital imaging, and CT, but MRI should also be used to assess the soft tissue. Recent advances in understanding this fracture have led to the development of different internal fixation devices and surgical procedures that provide stable fracture reduction and resistance to Achilles tendon forces. This article reviews the new insights into the anatomy, classification, risk factors, and treatment modalities of calcaneal tuberosity avulsion fracture in recent years.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Win Wah, Janneke Berecki-Gisolf, Karen Walker-Bone
Summary: This study aimed to identify the incidence and factors associated with in-hospital complications of work-related musculoskeletal injuries. The results showed that age, gender, area-level disadvantage, hospital type, comorbidity, emergency admissions, anesthesia, and the type of injury were all associated with in-hospital complications. The most common complications were cardiovascular, gastrointestinal complications and adverse drug events.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Gareth Rooke, Paul Sharplin, Richard Buckley
Summary: A 31-year-old female suffered a right fibula fracture with deltoid ligament injury after falling while climbing on wet rocks. She had ORIF surgery and recovered well, but has developed vague pain and hardware sensation at the lateral ankle 6 months later. Her past medical history includes breast reduction surgery and vaginal delivery, and she has a social history of alcohol consumption and past recreational drug use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng
Summary: This study compared the clinical outcomes of compression screw and non-weight-bearing techniques in treating pediatric Jones fractures. The results showed that compared to non-weight-bearing techniques, compression screw fixation can shorten the radiographic union time, immobilization time, and facilitate earlier return to full weight bearing and daily life. We recommend the use of compression screw fixation for widely displaced fractures and school-age active adolescents.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)