Article
Biotechnology & Applied Microbiology
Qi Liu, Haibo Mei, Guanghui Zhu, Ze Liu, Hongbin Guo, Min Wang, Jieyu Liang, Yi Zhang
Summary: The early PVR gradually increases in the first 3 months after osteotomy, which is significantly influenced by chronological age, sex, and the lengthening site. The early PVR may reflect the potential clinical outcome for bone lengthening.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Haoyu Zhao, Yachao Jia, Feng Wang, Yimin Chai, Chunfu Zhang, Jia Xu, Qinglin Kang
Summary: In this study, mesoporous silica-coated magnetic nanoparticles doped with cobalt ions were synthesized to accelerate bone repair. The results showed that local injection of these nanoparticles significantly accelerated bone healing in a mouse model. This study’s findings are important for expediting the treatment process of bone fractures.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Yanshi Liu, Feiyu Cai, Kai Liu, Jialin Liu, Xiaoxu Zhang, Aihemaitijiang Yusufu
Summary: The CDC technique has been found to improve bone regeneration during distraction osteogenesis, with better outcomes achieved by increasing the amplitude and slowing down the rate of the technique. The mechanism may involve the activation of the HIF pathway and enhancement of the osteogenic-angiogenic coupling.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Jiabing Fan, Xiao Zhang, Minjee Kang, Lauren Kim, Chung-Sung Lee, Danny Hadaya, Tara L. Aghaloo, Min Lee
Summary: This study presents a novel approach to enhance bone regeneration by targeting both the BMP antagonist noggin and agonist Trb3 without the use of exogenous BMP-2. In vitro studies showed that overexpression of Trb3 with simultaneous noggin suppression promotes osteogenic differentiation of mesenchymal stem cells. The researchers also developed a nonphospholipid liposomal system to achieve noggin suppression and Trb3 overexpression, leading to robust bone healing in vivo.
Article
Chemistry, Multidisciplinary
Zengjie Zhang, Fangqian Wang, Xin Huang, Hangxiang Sun, Jianxiang Xu, Hao Qu, Xiaobo Yan, Wei Shi, Wangsiyuan Teng, Xiaoqiang Jin, Zhenxuan Shao, Yongxing Zhang, Shenzhi Zhao, Yan Wu, Zhaoming Ye, Xiaohua Yu
Summary: The role of sensory innervation in bone homeostasis is often overlooked in bone repair strategies. This study proposes a neuromodulation approach that uses engineered sensory nerves (eSN) to optimize bone defect healing by leveraging the adaptive capabilities of sensory neurons. The release of NGF from ECM-constructed eSN promotes sensory neuron differentiation and enhances CGRP secretion, leading to improved mobility of RAOECs and osteogenic differentiation of BMSCs. The eSN approach effectively drives ossification in vivo through the NGF-TrkA signaling pathway, accelerating the healing of critical size bone defects. It also suppresses excessive bone formation and promotes bone remodeling by activating osteoclasts via a CGRP-dependent mechanism when combined with BMP-2 delivery, mitigating the side effects of BMP-2. Overall, this eSN approach offers a valuable avenue for optimizing bone homeostasis in various clinical scenarios by harnessing the adaptive role of the neural system.
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Cell & Tissue Engineering
Qi Chang, Masahito Fujio, Makoto Tsuboi, Huiting Bian, Masashi Wakasugi, Hideharu Hibi
Summary: This study evaluated high-mobility group box 1 (HMGB1) as a novel therapeutic target for distraction osteogenesis (DO) treatment. The results showed that HMGB1 promotes bone regeneration by recruiting PDGFRa and Sca-1 positive cells and endothelial progenitor cells, as well as accelerating angiogenesis. Therefore, HMGB1 may be a new therapeutic target for the acceleration of DO-driven bone regeneration.
Article
Engineering, Biomedical
Cheol Hee Jeong, Song-Yi Lim, Jo Eun Um, Hyo Won Lim, Kyu Ho Hwang, Kyeong-Mee Park, Jun Seop Yun, Dohun Kim, Jong-Ki Huh, Hyun Sil Kim, Jong In Yook, Nam Hee Kim, Yoon Hae Kwak
Summary: This study introduces micellized bone morphogenetic protein-2 (mPTD-BMP-2), a next-generation osteogenic supplement that combines protein transduction domain (PTD) and nano-sized micelle formulation technique to improve transduction efficiency and stability. The use of PTD represents a novel approach, and our results demonstrate the superiority of mPTD-BMP-2 over rh-BMP-2 in terms of in vivo pharmacokinetic profile and osteogenic potential, particularly in a rat tibial model of distraction osteogenesis.
ACTA BIOMATERIALIA
(2023)
Review
Agriculture, Dairy & Animal Science
Mario Garcia-Gonzalez, Fernando Munoz, Antonio Gonzalez-Cantalapiedra, Monica Lopez-Pena, Nikola Saulacic
Summary: Periosteal distraction osteogenesis (PDO) is a promising new technique for bone regeneration that has shown better results in animal models such as rabbits and rats compared to minipigs. The quality of studies has improved since the implementation of ARRIVE guidelines in 2010, but there is still room for enhancing transparency, comparability, and reproducibility in future research.
Article
Cell & Tissue Engineering
Y. Li, Y. Yang, M. Wang, X. Zhang, S. Bai, X. Lu, Y. Li, E. I. Waldorff, N. Zhang, W. Y. W. Lee, G. Li
Summary: The study compared a new, high slew rate (HSR) PEMF signal with different treatment durations with the standard FDA-approved signal, finding that HSR signal significantly enhances bone formation and could shorten daily treatment duration.
BONE & JOINT RESEARCH
(2021)
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Orthopedics
Chun-Hao Zhou, Ying Ren, Hui-Juan Song, Abdulnassir Adem Ali, Xiang-Qing Meng, Lei Xu, Hong-An Zhang, Jia Fang, Cheng-He Qin
Summary: One-stage radical debridement and bone transport has been proven to be a safe and effective method for treating static (or near static) lower limb osteomyelitis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Physiology
Kai Liu, Sulong Wang, Ainizier Yalikun, Peng Ren, Aihemaitijiang Yusufu
Summary: This study observed the effect of the accordion technique (AT) during the distraction phase on chondrogenesis and bone regeneration. It was found that low amplitude AT can enhance chondrogenesis and bone regeneration by activating the angiogenesis factor pathway and upregulating the expression of osteogenic-related biomarkers.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Nitchanant Kitcharanant, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review compiled and discussed the mechanisms underlying the effects of parathyroid hormone (PTH) on bone healing following distraction osteogenesis. The findings showed that PTH accelerates bone regeneration through its involvement in cell proliferation and differentiation, bone formation, and callus remodeling.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Critical Care Medicine
Andrija Jurina, Valentina Delimar, Zlatko Giljevic, Tajana Filipec Kanizaj, Andro Matkovic, Dinko Vidovic, Nikolina Jurjevic, Vinko Vidjak, Zeljko Duic, Mario Cuk, Mladen Japjec, Tomislav Dujmovic, Andrea Radeljak, Mirjana Marjana Kardum Paro, Marijana Vucic-Lovrencic, Mario Staresinic
Summary: This study investigated the prevalence of fragility spinal fractures among liver transplant candidates with cirrhosis. The results showed the detrimental impact of chronic liver disease and hepatic osteodystrophy on bone strength, and the correlation between DXA measurement and lumbar fragility fractures. These findings highlight the importance of adequate bone evaluation in liver transplant candidates.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
M. Scrivano, A. Vadal, G. Fedeli, R. Di Niccolo, D. Topa, S. Porcino, F. Pallotta, A. De Carli
Summary: This study compares the outcomes and complications of Ilioinguinal versus modified Stoppa approach in Open Reduction and Internal Fixation (ORIF) of anterior column acetabulum fractures. The results show that the modified Stoppa approach has a shorter operative time, less intra-operative blood loss, and fewer complications. The ilioinguinal approach achieves better anatomic reduction. However, there were no significant differences in terms of vascular lesions, clinical and functional outcomes between the two groups.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Jacob Hartline, Christopher T. Cosgrove, Nathan N. O'Hara, Qasim M. Ghulam, Zachary D. Hannan, Robert V. O'Toole, Marcus F. Sciadini, Christopher G. Langhammer
Summary: In a young, healthy orthopedic trauma population with isolated extremity injury, traditional demographic factors and ballistic injury mechanism have a greater predictive value for long-term mortality after hospital discharge compared to popular markers of socioeconomic status.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Youngmin Kwon, Jihye Lim, Chunui Lee
Summary: This study aims to investigate dental traumatic injuries related to standing electric scooters and compare them with injuries caused by other factors. The results indicate that crown-root fractures and avulsions are more common in electric scooter accidents. Additionally, relatively minor dental injuries, such as concussions and subluxations, are more likely to occur as combined injuries in electric scooter accidents. The study suggests the need for strengthened policies and enforcement of laws to prevent severe dental and craniofacial trauma associated with electric scooter use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
Summary: This study describes the histopathology of debrided bone tissue in chronic osteomyelitis (CO). The inflammatory response still exists after debridement, although it fades from the center. Sampling of debrided bone tissue must be performed initially during surgery to avoid underestimation of neutrophil infiltration.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Alejandro Alejandrez, Motasem Refaat, Yeng Vue
Summary: This study aims to assess the rate of operative fixation of sacral fractures in pelvises with dysmorphic and nondysmorphic sacrums, as well as whether a difference exists in fracture morphology between groups. The study found no statistical difference in operative fixation rates between pelvises with dysmorphic and nondysmorphic sacrums, but a difference in fracture patterns was observed.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Dong Wang, Shuo Diao, Xiaobin Zhou, Junlin Zhou, Yang Liu
Summary: This study discussed the role of fracture site tissue exosomes lncRNAs-mRNAs networks on post-injury adaptation (PIA) promoting bone mesenchymal stem cells (BMSCs) proliferation and migration. The results confirmed that PIA accelerated BMSCs proliferation and migration, and identified tissue exosomes as the key factor in this process. By analyzing the tissue exosomes lncRNAs-mRNAs networks, several hub genes, such as Akt1, Actb, and Uba52, were identified, and Kif11 was found to be a key gene in BMSCs regulated by tissue-derived exosomes of PIA treated rats.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Lisa Reider, Jason R. Falvey, Safiyyah M. Okoye, Jennifer L. Wolff, Joseph F. Levy
Summary: Falls are a leading cause of injury and hospital readmissions in older adults, with over 3 million seeking hospital care for fall injuries annually in the United States. The annual acute treatment costs for these injuries amount to $20 billion, indicating the urgent need for evidence-based fall prevention interventions and investments in geriatric emergency departments.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Mohamed Elbuzidi, Alyssa N. Wenzel, Andrew Harris, Majd Marrache, Julius K. Oni, Harpal S. Khanuja, Vishal Hegde
Summary: A retrospective propensity score matched cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database to compare outcomes for patients with recently diagnosed COVID-19 infection and those without COVID-19 infection undergoing operative treatment of hip fractures. The results showed that COVID-19-positive patients had a higher risk of 30-day mortality, pneumonia, unplanned intubation, septic shock, longer length of hospital stay, and discharge to an acute care hospital. Active COVID-19 infection is an independent risk factor for complications and increased resource utilization in these patients.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Jorge Mayor, Vera Birgel, Jan-Dierk Clausen, Goekmen Aktas, Stephan Sehmisch, Ann-Kathrin Einfeldt, Vasilis Giannoudis, Ahmed H. K. Abdelaal, Emmanouil Liodakis
Summary: This study provides a comprehensive overview of biomechanical research on the treatment of intertrochanteric fractures using cephalomedullary devices. Through a systematic literature search and synthesis analysis, the study highlights the need for standardization in biomechanical studies, and suggests strategies to enhance construct stability. The findings emphasize the importance of further research and meta-analyses to establish standardized protocols and enhance reliability.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Patricia Rodarte, Jamieson O'Marr, Billy Haonga, Deogratias Patrick, Kian Niknam, Mayur Urva, Abigail Cortez, Willem-Jan Metsemakers, David Shearer, Saam Morshed
Summary: This study evaluates the diagnostic performance of telephone questionnaires in identifying patients with fracture-related infections (FRIs) after open tibia fracture fixation in Tanzania. The study shows that telephone questionnaires have adequate diagnostic performance, with drainage being the main indicator for FRIs.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Zhiyi Liu, Guodong Hou, Wencong Zhang, Junyan Lin, Jinrong Yin, Huan Chen, Guowei Huang, Aiguo Li
Summary: Calcaneal tuberosity avulsion fracture, an extra-articular injury, is a rare fracture caused internally by intense contraction of the gastrocnemius-soleus complex, and externally by low-energy (possibly high-energy). The risk of injuries to the skin and Achilles tendon around the calcaneal tuberosity is closely related to the Lee classification and Carnero-Martin de Soto Classification of this type of fracture. Diagnosis is typically confirmed through X-ray, digital imaging, and CT, but MRI should also be used to assess the soft tissue. Recent advances in understanding this fracture have led to the development of different internal fixation devices and surgical procedures that provide stable fracture reduction and resistance to Achilles tendon forces. This article reviews the new insights into the anatomy, classification, risk factors, and treatment modalities of calcaneal tuberosity avulsion fracture in recent years.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Win Wah, Janneke Berecki-Gisolf, Karen Walker-Bone
Summary: This study aimed to identify the incidence and factors associated with in-hospital complications of work-related musculoskeletal injuries. The results showed that age, gender, area-level disadvantage, hospital type, comorbidity, emergency admissions, anesthesia, and the type of injury were all associated with in-hospital complications. The most common complications were cardiovascular, gastrointestinal complications and adverse drug events.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Article
Critical Care Medicine
Gareth Rooke, Paul Sharplin, Richard Buckley
Summary: A 31-year-old female suffered a right fibula fracture with deltoid ligament injury after falling while climbing on wet rocks. She had ORIF surgery and recovered well, but has developed vague pain and hardware sensation at the lateral ankle 6 months later. Her past medical history includes breast reduction surgery and vaginal delivery, and she has a social history of alcohol consumption and past recreational drug use.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)
Review
Critical Care Medicine
Yuwei Wen, Danjiang Zhu, Qiang Wang, Baojian Song, Wei Feng
Summary: This study compared the clinical outcomes of compression screw and non-weight-bearing techniques in treating pediatric Jones fractures. The results showed that compared to non-weight-bearing techniques, compression screw fixation can shorten the radiographic union time, immobilization time, and facilitate earlier return to full weight bearing and daily life. We recommend the use of compression screw fixation for widely displaced fractures and school-age active adolescents.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2024)