Journal
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
Volume 39, Issue -, Pages S37-S42Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.injury.2008.06.015
Keywords
NGF; BDNF; CNTF; GDNF; NT-3; Neurotrophin; Neurokines; Transforming growth factor
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Neurotrophic factors are a family of polypeptides required for survival of discrete neuronal populations. In the normal state such factors are mostly synthesised by target tissues and are used for the viability of the nerve-cell bodies. After nerve injury, neurotrophic factors (NFs) are synthesised by non-neuronal (Schwann cells and fibroblasts) in the nerve trunk, and act to support the outgrowth of axons. NFs can be classified into three major groups: (1) neurotrophins; (2) neurokines; and (3) the transforming growth factor beta (TGF)-beta superfamily. (C) 2008 Published by Elsevier Ltd.
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