Journal
MECHANISMS OF DEVELOPMENT
Volume 137, Issue -, Pages 11-22Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2015.04.003
Keywords
Hedgehog; Axon; Drosophila; Patched; Frazzled; DCC
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Funding
- Spanish Ministerio de Ciencia y Innovacion
- Eramus programme
- FPU fellowship [FPU 12/05765]
- Spanish Ministerio de Ciencia y Innovacion [RYC-2007-00417]
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We report that the morphogen Hedgehog (Hh) is an axonal chemoattractant in the midline of Drosophila melanogaster embryos. Hh is present in the ventral nerve cord during axonal guidance and overexpression of hh in the midline causes ectopic midline crossing of FasII-positive axonal tracts. In addition, we show that Hh influences axonal guidance via a non-canonical signalling pathway dependent on Ptc. Our results reveal that the Hh pathway cooperates with the Netrin/Frazzled pathway to guide axons through the midline in invertebrates. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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