Review
Chemistry, Multidisciplinary
Laura Schroeter, Natascia Ventura
Summary: Nanoplastic particles (NPs) can be found in the air, water, and food, either produced or derived from daily used products. Recent studies have shown that these particles are internalized in different forms in aquatic organisms, terrestrial organisms, and human cell lines, leading to toxic effects on health. This overview summarizes the toxic effects of NPs from studies in cellular systems and in vivo models, and discusses important aspects such as particle internalization mechanisms and structural modifications. While there are still gaps in the field, more systematic studies and the use of in vivo model organisms can improve our understanding of important aspects of NPs.
Article
Cell Biology
Celine-Hivda Yegen, Liasmine Haine, Kevin Da Costa Ferreira, Dominique Marchant, Jean-Francois Bernaudin, Carole Planes, Nicolas Voituron, Emilie Boncoeur
Summary: Researchers have developed an experimental mice model of lung fibrosis AE, mimicking IPF-AE at various levels, which could be useful for preclinical trials.
Article
Pharmacology & Pharmacy
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Yunfeng Xiao, Lanbing Zheng, Yu Dong
Summary: The study found that Jaranol was relatively safe in mice when administered orally in both acute and sub-acute toxicity tests, but caused changes in body weight and biochemical parameters. More chronic toxicity studies are recommended to ensure its safety for human use.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Giovanni Sitia, Fabio Fiordaliso, Martina B. Violatto, Jennifer Fernandez Alarcon, Laura Talamini, Alessandro Corbelli, Lorena Maria Ferreira, Ngoc Lan Tran, Indranath Chakraborty, Mario Salmona, Wolfgang J. Parak, Luisa Diomede, Paolo Bigini
Summary: Food-grade titanium dioxide (E171) contains nanoparticles that pose potential risks to human and animal health. This study evaluated the impact of E171 on invertebrate and vertebrate animals, finding significant impairments in pharyngeal function, reproduction, and development, as well as inflammation and parenchymal modifications in the liver and lungs.
Article
Food Science & Technology
David B. Warheit, Leonard S. Levy
Summary: The study aimed to assess lung toxicity in rats exposed to Terracess JS particles and compared the effects to vehicle controls and Min-U-Sil alpha-quartz particles. The results demonstrated that Terracess JS particles did not produce significant lung inflammatory or cell injury effects in rats, in contrast to the effects observed with alpha-quartz particles.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Naresh Singh, Naveen Arora
Summary: The study found that exposure to diesel exhaust in mice led to lung injury and pulmonary fibrosis, as evidenced by impaired lung function, cellular infiltration, inflammation, thickening of the alveolar wall, and tissue remodeling. The involvement of the TGF-beta/SMAD3 pathway and activation of EMT in diesel exhaust-exposed mice was demonstrated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Microbiology
Qi Liu, Wei Jiang, Yun Chen, Manyu Zhang, Xiaoling Geng, Quan Wang
Summary: A mouse model of acute Toxoplasma gondii infection was established, identifying three potential diagnostic candidates and showing a slightly longer lifespan in challenged mice.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
May Nasser Bin-Jumah, Muhammad Shahid Nadeem, Sadaf Jamal Gilani, Syed Sarim Imam, Sultan Alshehri, Imran Kazmi
Summary: The study developed a spray drying process without the use of organic solvents for preparing novel Karaya gum polymer microparticles of Ganoderma lucidum polysaccharide (GLP). The prepared microparticles showed a protective effect against CAD-induced male reproductive testicular toxicity. Furthermore, CAD altered sex hormones, oxidative stress, and inflammatory cytokines, while GLP MPs pre-treatment significantly attenuated these toxic effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Energy & Fuels
Dariusz Kurczynski, Piotr Lagowski, Grzegorz Wcislo
Summary: The study investigated the impact of second-generation biofuels, specifically BBuE, on exhaust gas composition from a diesel engine. Results showed that by powering the engine with BBuE, lower concentrations of carbon monoxide, carbon dioxide, hydrocarbons, particulate matter, and nitrogen oxides were achieved compared to using first-generation biofuel RME or diesel fuel DF. This suggests that new-generation biofuels emit fewer undesirable exhaust gas components into the atmosphere.
Article
Biochemistry & Molecular Biology
Joong Won Lee, Jin Sik Kim, Hee Jae Lee, Ji-Hye Jang, Ja-Hyun Kim, Woo Jong Sim, Yong-beom Lim, Ji-Won Jung, Hyun Joung Lim
Summary: This study evaluated the DNA damage potency of PM2.5 in old male and female mice, finding that DEP exposure did not induce systemic genotoxic effects in bone marrow but did cause significant DNA damage in lung specimens. The positive relationship between DEP exposure and DNA damage was stronger in the older group, indicating a modifying effect of age on this association. These results suggest that age should be considered when studying the cellular adverse effects of PM2.5.
Article
Engineering, Chemical
Yunkai Cai, Chuang Xiang, Neng Zhu, Lin Lv
Summary: This study investigated the effects of C3H6 and CO2 on desulfurization, denitrification, and the formation of by-product CO by nonthermal plasma (NTP) under simulated diesel exhaust conditions. Optical emission spectroscopy (OES) was used to observe the plasma process and detect the emission intensities of O and OH radicals. The results showed that CO2 concentration had negligible effect on the formation of O and OH radicals, while every 1% increase in CO2 concentration led to a 22.5 ppm increase in CO concentration. Increasing the C3H6 concentration from 0 to 600 ppm improved the NO removal efficiency from 42.8% to 70.5%. However, the presence of C3H6 had marginal effect on the removal of SO2. C3H6 was found to be an effective additive for the oxidative removal of NO. However, the formation of by-product CO and unreacted C3H6 should also be considered.
PLASMA CHEMISTRY AND PLASMA PROCESSING
(2023)
Article
Pharmacology & Pharmacy
Hui Li, Xinyu Li, Yu Hao, Chenghua Wu, Yuhao Fu, Nana Su, Houlin Chen, Binyu Ying, Haixing Wang, Lihuang Su, Haijian Cai, Qinlian He, Mengsi Cai, Junwei Sun, Jing Lin, Aaron Scott, Fanggao Smith, Xiaoying Huang, Shengwei Jin
Summary: This study found that Maresin 1 can improve abnormal pulmonary vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) mice, and exert its effects by inhibiting proliferation and promoting apoptosis of pulmonary artery smooth muscle cells (PASMC). This suggests that Maresin 1 may have a potent therapeutic effect in vascular diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Environmental Sciences
Jianzhong Zhang, Xinmin Jiang, Xin Li, He Sun, Mingyue Wang, Wanjun Zhang, Haonan Li, Hongmei Wang, Min Zhuang, Lin Zhang, Lin Lu, Jinglong Tang
Summary: Chlorhexidine, a commonly used guanidine disinfectant, may cause lung injury and fibrosis. Inhalation of chlorhexidine aerosol can induce an inflammatory response and activate pathways related to extracellular matrix deposition. Furthermore, chlorhexidine exposure may induce fibrosis-like injury by enhancing mucus secretion.
Article
Biochemistry & Molecular Biology
Luca Massimino, Alessandra Bulbarelli, Paola Antonia Corsetto, Chiara Milani, Laura Botto, Francesca Farina, Luigi Antonio Lamparelli, Elena Lonati, Federica Ungaro, Krishna Rao Maddipati, Paola Palestini, Angela Maria Rizzo
Summary: Airborne ultrafine particles (UFPs) pose a significant risk to health, as they have been linked to increased cardiovascular mortality, neurodegenerative diseases, and occupational and environmental morbidity. In this study, the researchers investigated the impact of acute and subacute exposure to diesel exhaust particles (DEPs) on polyunsaturated fatty acid-derived lipid mediators (LMs) in mouse lung and cortex. The findings suggest that lipids play a crucial role in DEP-induced tissue damage, as they are associated with inflammatory processes and oxidative stress.
Article
Environmental Sciences
Jaeseong Jeong, Su-yong Bae, Jinhee Choi
Summary: Diesel particulate matter (DPM) is a major subset of urban fine particulate matter (PM2.5) and has been classified as a group 1 carcinogen due to its complex mixture of various chemicals. Using the Adverse Outcome Pathway (AOP) approach, we identified the toxicity pathway of DPM and demonstrated the usefulness of ToxCast and deep learning models in determining potential toxicity pathways of chemical mixtures like DPM.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Patricia Teixeira Santana, Tatiana Luna-Gomes, Marcos Vinicius Rangel-Ferreira, Augusto Shuiti Tamura, Carolyne Lalucha Alves Lima Da Graca, Mariana Nascimento Machado, Walter Araujo Zin, Christina Maeda Takiya, Debora Souza Faffe, Robson Coutinho-Silva
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Anesthesiology
Umberto Lucangelo, Milos Ajcevic, Enrico Lena, Massimo Ferluga, Lucia Comuzzi, Agostino Accardo, Walter A. Zin
Summary: This study aimed to provide an in vitro estimation of pressure drop across tracheal tubes under given pulsatile frequencies and peak pressures. A non-linear model was constructed to evaluate the relationships between different parameters, and the model showed good performance in predicting the pressure drop. If clinically confirmed, the use of a nonconventional ventilatory strategy like HFPV could be safer and more convenient for physicians to evaluate pressure changes.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2021)
Article
Cardiac & Cardiovascular Systems
Naomi K. Nakagawa, Katia M. G. Oliveira, Andrew Lockey, Federico Semeraro, Priscila Aikawa, Mariangela Macchione, Regiani Carvalho-Oliveira, Gabriela B. Gouvea, Ana Paula Boaventura, Adalgisa Maiworm, Marcelo Calderaro, Ludhmila A. Hajjar, Eduardo Motta, Heraldo P. Souza, Carmen D. S. de Andre, Luiz F. F. Silva, Thatiane F. Polastri, Sergio Timerman, Maria Jose C. Carmona, Bernd W. Boettiger
Summary: Observational study comparing 40-minute and 120-minute CPR training programs found that the lower-cost 40-minute handmade model had a higher success rate than the intermediate-cost 120-minute model. Success rates varied among learners of different ages within the same program, with success increasing with age.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Environmental Sciences
Regiani Carvalho-Oliveira, Luis F. Amato-Lourenco, Pamela S. Almeida, Bianca B. M. Garcia, William K. M. Vieira, Ariane Santana, Martha Cristina Motta Godinho-Netto, Maria E. Carretero, Paulo H. Nascimento Saldiva, Thais Mauad
Summary: Chronic exposure to traffic from heavy-duty diesel-fueled vehicles can lead to respiratory symptoms and airway inflammation, with older adults showing greater susceptibility than younger adults.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medicine, General & Internal
Alysson Roncally S. Carvalho, Alan R. Guimaraes, Flavio R. Sztajnbok, Rosana Souza Rodrigues, Bruno Rangel Antunes Silva, Agnaldo Jose Lopes, Walter Araujo Zin, Isabel Almeida, Manuela Maria Franca
FRONTIERS IN MEDICINE
(2020)
Article
Environmental Sciences
Felipe Gomes Pinheiro, Maria Diana Moreira-Gomes, Mariana Nascimento Machado, Tailane dos Santos Almeida, Priscila da Penha Apolinario Barboza, Luis Felipe Silva Oliveira, Francisco Sales Avila Cavalcante, Jose Henrique Leal-Cardoso, Rodrigo Soares Fortunato, Walter Araujo Zin
Summary: Exposure to C-60 emulsion deteriorates lung morphofunctional, redox, and inflammatory characteristics, increasing the risk of infertility. Eugenol can avoid these changes, but does not prevent sperm damage.
ENVIRONMENTAL POLLUTION
(2021)
Article
Nanoscience & Nanotechnology
Dayene de Assis Fernandes Caldeira, Flavia Muniz Mesquita, Felipe Gomes Pinheiro, Dahienne Ferreira Oliveira, Luis Felipe Silva Oliveira, Jose Hamilton Matheus Nascimento, Christina Maeda Takiya, Leonardo Maciel, Walter Araujo Zin
Summary: In a study on male BALB/c mice, exposure to C60 fullerene nanoparticles led to impaired lung mechanics and mitochondrial function, increased reactive oxygen species concentration, and decreased ATP production.
Article
Medicine, General & Internal
Alysson Roncally S. Carvalho, Alan Guimaraes, Gabriel Madeira Werberich, Stephane Nery de Castro, Joana Sofia F. Pinto, Willian Reboucas Schmitt, Manuela Franca, Fernando Augusto Bozza, Bruno Leonardo da Silva Guimaraes, Walter Araujo Zin, Rosana Souza Rodrigues
FRONTIERS IN MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Priscila Apolinario Barboza, Mariana Nascimento Machado, Dayene de Assis Ferenandes Caldeira, Milena Simoes Peixoto, Luis Felipe Cruz, Christina Maeda Takiya, Alysson Roncally Carvalho, Mariana Boechat de Abreu, Rodrigo Soares Fortunato, Walter Araujo Zin
Summary: The study evaluated the pulmonary outcomes of acute CYN intoxication and found that dexamethasone could partially mitigate the toxic effects of CYN, improving some characteristics of the lungs and liver.
Article
Physiology
Alysson Roncally Silva Carvalho, Alan Guimaraes, Thiego de Souza Oliveira Garcia, Gabriel Madeira Werberich, Victor Fraga Ceotto, Fernando Augusto Bozza, Rosana Souza Rodrigues, Joana Sofia F. Pinto, Willian Reboucas Schmitt, Walter Araujo Zin, Manuela Franca
Summary: The study aimed to estimate the extent and severity of COVID-19 pneumonia by adjusting the volume and weight of abnormal pulmonary opacities (PO) to predicted CTLV and CTLW, and evaluate their association with clinical and radiological outcomes. The findings suggest that COVID-19 patients with diffuse and severe pneumonia at admission had worse outcomes compared to those with moderate and limited/mild pneumonia. Additionally, pneumonia severity, but not extent, was moderately correlated with age and CRP concentration.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pathology
Robson Seriani, Carla Peres de Paula, Anderson Ferreira da Cunha, Marcos Antonio de Oliveira, Paloma Gava Krempel, Daniela Perroni Frias, Elnara Marcia Negri, Thais Mauad, Mariangela Macchione
Summary: Exposure to diesel exhaust particles may decrease the gene expression patterns of the PRDX family in bronchial epithelial airway cells, leading to an increase in oxidative stress levels.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Engineering, Environmental
Luis Fernando Amato-Lourenco, Regiani Carvalho-Oliveira, Gabriel Ribeiro Junior, Luciana dos Santos Galvao, Romulo Augusto Ando, Thais Mauad
Summary: This study confirmed the presence of microplastics in human lung tissues, with polyethylene and polypropylene being the most frequently detected polymers. The potential adverse effects of these microplastics on the respiratory system following inhalation are still unknown, but further research is needed to understand the heterogeneous characteristics of these contaminants.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Luis Fernando Amato-Lourenco, Natalie de Souza Xavier Costa, Katia Cristina Dantas, Luciana dos Santos Galva, Fernando Negri Moralles, Suzette Cleuza Ferreira Spina Lombardi, Alfredo Mendroni Junior, Jose Angelo Lauletta Lindoso, Romulo Augusto Ando, Felipe Gallego Lima, Regiani Carvalho-Oliveira, Thais Mauad
Summary: The study found SARS-CoV-2 and microplastics in the outdoor air around the largest medical center in Latin America, with polyester being the most common polymer in the samples. The total amount of microplastics was positively associated with the SARS-CoV-2 viral load and negatively associated with temperature and relative humidity.
ENVIRONMENTAL POLLUTION
(2022)
Article
Multidisciplinary Sciences
Luis Fernando Amato-Lourenco, Natalia de Souza Xavier Costa, Katia Cristina Dantas, Suzette Cleuza Ferreira Spina Lombardi, Alfredo Mendroni Junior, Jose Angelo Lauletta Lindoso, Felipe Gallego Lima, Regiani Carvalho-Oliveira, Thais Mauad
Summary: Based on the study, SARS-CoV-2 RNA aerosol contamination was found in various hospital settings in Sao Paulo, Brazil. Higher concentrations of the E-gene were detected in the autopsy room and non-COVID wards, compared to the COVID-19 ward.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Luis Fernando Amato-Lourenco, Luciana dos Santos Galvao, Helio Wiebeck, Regiani Carvalho-Oliveira, Thais Mauad
Summary: Plastics degrade into microplastics in the atmosphere, posing a threat to ecosystems and human health. This study examines the amount, composition, and characteristics of airborne microplastics in the megacity of Sao Paulo, as well as the influence of weather and seasons on their deposition.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)