Article
Oncology
Zhaoning Xu, Pingping Li, Chi Zhang, Dedong Ma
Summary: Heated humidified high-flow nasal cannula (HFNC) oxygen therapy has shown good efficacy and safety in relieving dyspnea in advanced cancer patients. It can be considered as the first choice of oxygen therapy for these patients due to its positive effects on dyspnea, oral dryness, and sleep condition. HFNC therapy also has potential for broader clinical application.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Critical Care Medicine
Maria Tholen, Sven-Erik Ricksten, Lukas Lannemyr
Summary: The study demonstrates that levosimendan can increase renal blood flow and improve renal function in patients with AKI after cardiac surgery by dilating renal blood vessels. Compared to the placebo group, the levosimendan group showed a significant increase in renal blood flow, a significant decrease in renal vascular resistance, and a significant increase in the need for norepinephrine dosage.
Article
Medicine, General & Internal
Matheus Bertanha, Lenize da Silva Rodrigues, Pedro Luciano Mellucci Filho, Andrei Moroz, Maria Ines de Moura Campos Pardini, Marcone Lima Sobreira, Edison Luiz Durigon, Rafael Rahal Guaragna Machado, Rejane Maria Tommasini Grotto, Marcelo Andrade de Lima, Helena Bonciani Nader, Marli Leite de Moraes, Alexandre Naime Barbosa, Natalia Bronzatto Medolago, Fabio Florenca Cardoso, Angelo Jose Magro, Cristiane Rodrigues Guzzo Carvalho, Leonardo Nazario de Moraes, Rita de Cassia Alvarado, Helga Caputo Nunes, Gustavo Constantino de Campos, Vinicius Tadeu Ramos da Silva Grillo, Nathalia Dias Sertorio, Carlos Magno Castelo Branco Fortaleza
Summary: This study plans to conduct a clinical trial on the effectiveness of enriched heparin in treating COVID-19. The purpose of the trial is to evaluate the safety and efficacy of enriched heparin in alleviating viral replication. The study will be divided into a placebo group and an intervention group, with a total of 50 participants involved.
Article
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Stephen J. Greene, Anne S. Hellkamp, Adam D. DeVore, Xian Shen, Nancy M. Albert, J. Herbert Patterson, John A. Spertus, Laine E. Thomas, Fredonia B. Williams, Adrian F. Hernandez, Gregg C. Fonarow, Javed Butler
Summary: In this study involving 3426 US outpatients with chronic heart failure, one in four patients received outpatient escalation of diuretic therapy, which was associated with signs/symptoms of congestion. Any degree of outpatient diuretic dose escalation was linked to heart failure hospitalizations and resource utilization, but not with all-cause mortality.
CIRCULATION-HEART FAILURE
(2021)
Article
Ophthalmology
Hamid Alemi, Shima Dehghani, Katayoon Forouzanfar, Pier Luigi Surico, Akitomo Narimatsu, Aytan Musayeva, Sina Sharifi, Shudan Wang, Thomas H. Dohlman, Jia Yin, Yihe Chen, Reza Dana
Summary: This study successfully developed a mouse model of mustard gas keratopathy using ocular NM exposure and described the subsequent structural changes in the cornea. The model can be used to study ocular injuries caused by mustard gas.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Samad Ghodrati, Mohammad Memarian, Shohreh Alian Samakkhah, Masoud Asadi-Khiavi, Aiyoub Pezeshgi
Summary: This study aimed to determine the efficacy of low dose inhaled morphine for respiratory function improvement in patients exposed to mustard gas. The results showed that inhaled low dose morphine significantly improved patients' maximum expiratory flow, severity of dyspnea, quality of life, and frequency of coughing during the day.
CASPIAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Leila Shahbaznejad, Alireza Davoudi, Gohar Eslami, John S. Markowitz, Mohammad Reza Navaeifar, Fatemeh Hosseinzadeh, Faeze Sadat Movahedi, Mohammad Sadegh Rezai
Summary: This study found that a single dose of ivermectin improved important clinical features of COVID-19 in symptomatic patients, including dyspnea, cough, and lymphopenia. Further research with larger sample sizes and different dosages may be needed to fully understand the potential benefits of ivermectin in the treatment of COVID-19.
CLINICAL THERAPEUTICS
(2021)
Article
Toxicology
Patrick M. McNutt, Kyle E. M. Kelly, Amber C. Altvater, Marian R. Nelson, Megan E. Lyman, Sean O'Brien, Matthieu T. Conroy, Celinia A. Ondeck, Skylar M. L. Bodt, Sarah E. Wolfe, Susan M. Schulz, Denise M. Kniffin, Nicole B. Hall, Tracey A. Hamilton
Summary: The study characterized the effects of SM dose on corneal injury progression using clinical, histological, and ultrastructural analyses. It found that RELs are a programmed pathophysiological response to severe alkylating lesions, leading to the development of secondary corneal pathophysiologies.
TOXICOLOGY LETTERS
(2021)
Article
Pediatrics
Shilpa Abraham, Ramachandran Rameshkumar, Muthu Chidambaram, Rajendran Soundravally, Seenivasan Subramani, Rohit Bhowmick, Abraar Sheriff, Kaushik Maulik, Subramanian Mahadevan
Summary: The study aimed to investigate the impact of furosemide infusion on the progression of acute kidney injury in critically ill children. However, the results showed that furosemide did not reduce the proportion of patients progressing to a higher stage of kidney injury, and had no significant effect on other outcome measures.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Immunology
Nayara M. Arruda, Leandro G. Braz, Flavia R. Nogueira, Katina M. Souza, Aline G. Aun, Lidia R. de Carvalho, Jose Reinaldo C. Braz, Mariana G. Braz
Summary: In a study comparing the effects of nitrous oxide (N2O) with desflurane anesthesia to desflurane alone in patients undergoing minor surgery, it was found that there were no significant differences in inflammatory markers. Both groups showed a significant increase in systemic IL-6 and hs-CRP values one day after surgery, as well as an increase in prolactin levels intraoperatively. These results suggest that N2O does not worsen inflammatory and neuroendocrine responses when used in conjunction with desflurane anesthesia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Mohammad Hasan Rabiee, Mostafa Ghanei, Hossein Amini, Aliasghar Akhlaghi
Summary: This study investigated the long-term mortality rate among civilian people exposed to mustard gas (MG) during the Iran-Iraq war in Sardasht, Iran after 32 years. The results showed that acute exposure to MG, even without protective clothing and masks, does not increase all-cause mortality after 32 years if accompanied by special and ongoing care for those exposed. However, the observed deaths due to respiratory diseases were higher than expected.
Article
Multidisciplinary Sciences
Alleluia Lima Losno Ledesma, Daniele Leite Rodrigues, Isabella Monteiro de Castro Silva, Carlos Augusto Oliveira, Fayez Bahmad
Summary: The study found that 300 mg of caffeine did not significantly alter the psychoacoustic measures, electroacoustic measures or the degree of discomfort related to tinnitus in patients.
Article
Chemistry, Medicinal
Reyhaneh Gudarzi, Fatemeh Shabani, Sakineh Mohammad-Alizadeh-Charandabi, Elham Naghshineh, Elnaz Shaseb, Mojgan Mirghafourvand
Summary: This study aimed to determine the effect of curcumin on painful symptoms and quality of life in women with endometriosis. The results showed that curcumin did not have a significant impact on pain symptoms or quality of life. Future clinical trials are needed to further investigate the role of curcumin in endometriosis.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Medicinal
Zohreh Ghaem Far, Siavash Babajafari, Javad Kojuri, Salman Mohammadi, Mehran Nouri, Pouya Rostamizadeh, Mohammad Hossein Rahmani, Mohsen Azadian, Elham Ashrafi-Dehkordi, Alireza Zareifard, Reza Golchin Vafa, Seyed Mohammad Mazloomi
Summary: The study found that spirulina-fortified dressing significantly reduced blood pressure and certain lipid levels in patients with hypertension, showing potential in alleviating chronic diseases.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Ali Khamevar, Mohammad Ali Ebrahimzadeh, Mahmood Moosazadeh, Masoud Shayesteh Azar, Majid Saeedi, Adel Bakhtiary Far, Seyde Sedighe Yousefi
Summary: A clinical trial involving 60 elderly patients showed that Pistacia atlantica gum ointment significantly improved symptoms of knee osteoarthritis, including reducing joint stiffness, pain, and improving function compared to a placebo.
PHYTOTHERAPY RESEARCH
(2021)
Article
Obstetrics & Gynecology
Farideh Zafari Zangeneh, Samad Muhammadnejad, Mohammad Mehdi Naghizadeh, Mina Jafarabadi, Maryam Sarmast Shoushtari, Masoumeh Masoumi
Summary: In women with PCOS, the sympathetic nervous system is hyperactive, and clonidine can help modulate this activity. The study showed that clonidine can increase oocyte maturity and pregnancy rate in PCO women, both in vivo and in vitro. These findings have implications for the pharmacological treatment of anovulation and assisted reproductive technology.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Endocrinology & Metabolism
Saeideh Zareei, Fatemeh Behrasi, Mohammad Mehdi Naghizadeh, Fatemeh Talebzadeh, Ali Kharmandar, Sayed Hosein Davoodi, Maryam Asadi, Mojtaba Farjam, Reza Homayounfar
Summary: The study found that the risk of developing MetS was higher in oral contraceptive pill users compared to non-users, and this risk increased after adjusting for confounding factors. It is recommended for physicians to monitor MetS development in OCP recipients.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2022)
Article
Social Work
Heshmatollah Nourmoradi, Mahdieh Asadi, Mohammad Mehdi Naghizadeh, Sajad Mazloomi, Hassan Asadi, Zeinab Ghazanfari
Summary: The study found that parents' education level and father's occupation were related to students' environmental knowledge, and students' environmental behavior was influenced by their school level and family income. Students in the intervention group showed a stronger sense of responsibility for saving water and heating energy, as well as proper waste management in the school environment.
JOURNAL OF HUMAN BEHAVIOR IN THE SOCIAL ENVIRONMENT
(2022)
Correction
Multidisciplinary Sciences
Maryam Kazemi, Mina Bazyar, Mohammad Mehdi Naghizadeh, Azizallah Dehghan, Massih Sedigh Rahimabadi, Mahsa Rostami Chijan, Mostafa Bijani, Maryam Zahmatkeshan, Alireza Ghaemi, Nastaran Samimi, Reza Homayounfar, Mojtaba Farjam
SCIENTIFIC REPORTS
(2022)
Correction
Multidisciplinary Sciences
Mohammad Ariya, Jalal Karimi, Somayeh Abolghasemi, Zeinab Hematdar, Mohammad Mehdi Naghizadeh, Maryam Moradi, Reza Barati-Boldaji
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Zahra Firoozi, Elham Mohammadisoleimani, Abbas Shahi, Mohammad Mehdi Naghizadeh, Ebrahim Mirzaei, Ali Ghanbari Asad, Zahra Salmanpour, Seyed Mohamad Javad Nouri, Yaser Mansoori
Summary: This study evaluated the expression and roles of hsa_circ_0000479/hsa-miR-149-5p/RIG-I, IL-6 in COVID-19 infection. The results showed that the expression levels of these genes were increased in COVID-19 patients, while hsa-miR-149-5p expression was decreased. Additionally, there were correlations between these genes and the PI3K-AKT and STAT3 signaling pathways.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Elham Mohammadisoleimani, Zahra Firoozi, Mohammad Mehdi Naghizadeh, Ali Ghanbari Asad, Babak Pezeshki, Yousef Gholampour, Ebrahim Mirzaei, Mohamadhosain Simin, Mahsa Saliani, Ali Moravej, Zolfaghar Armoon, Yaser Mansoori
Summary: The study revealed that hsa_circ_0004812, IL6R, and RIG-I are expressed at higher levels in severe symptom group of COVID-19 patients compared to asymptomatic or healthy control groups. Moreover, hsa-miR-1287-5p expression is positively correlated with symptoms in patients and hsa_circ_0004812 is predicted to sponge hsa-miR-1287-5p in a competitive manner.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Mohammad Ariya, Zahra Esmaeilinezhad, Mohammad Mehdi Naghizadeh, Mohammad Mehdi Dindarloo, Farzaneh Karimi, Fatemeh Kaveh, Sahar Marzban, Kimia Hormozi, Reza Barati-Boldaji
Summary: This study investigates the barriers to whole grain consumption among Iranian students and finds that factors such as access issues, family supply issues, lack of attractiveness, non-consumption by classmates, and high prices contribute to students avoiding whole grain products. Additionally, students who prefer white bread have lower appetite levels and tend to eat fast food more often compared to those who eat whole grains.
SCIENTIFIC REPORTS
(2022)
Article
Genetics & Heredity
Arezoo Faridzadeh, Mahmoud Mahmoudi, Sara Ghaffarpour, Mohammad Saber Zamani, Akram Hoseinzadeh, Mohammad Mehdi Naghizadeh, Tooba Ghazanfari
Summary: This study aimed to evaluate the association of ACE1 and ACE2 gene polymorphisms with the severity of COVID-19. The findings suggest that the ACE1 DD genotype is inversely correlated with intubation risk and mortality in COVID-19 patients. Additionally, the ACE2 rs1978124 CT and TT genotypes have a positive role in susceptibility to COVID-19 in females, but a protective effect against the severity of the disease.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Roya Mehdizade Tazangi, Mostafa Bijani, Shahnaz Karimi, Mohammad Mehdi Naghizadeh, Ali Khani Jeihooni, Mohammadhossein Rahimzahedi
Summary: The study demonstrates that PGBT using HBM can significantly improve the quality of life and self-care behavior of patients with type 2 diabetes.
CLINICAL DIABETOLOGY
(2022)
Article
Pathology
Elham Mohammadisoleimani, Zahra Firoozi, Mohammad Mehdi Naghizadeh, Ali Ghanbari Asad, Anahita Jafari, Mohammad Hosein Pourjafarian, Ali Ariafar, Hosein Mansoori, Hassan Dastsooz, Hani Sabaie, Shahryar Zeighami, Yaser Mansoori
Summary: This study investigated the expression and potential mechanism of four circRNAs in renal cell carcinoma (RCC). The results showed that the expression of these circRNAs was downregulated in RCC tissues and significantly lower in patients with a history of kidney disease. Furthermore, specific circRNAs showed higher expression in tumors with lympho-vascular/perineural invasion and oncocytoma type.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Reza Homayounfar, Mojtaba Farjam, Ehsan Bahramali, Mehdi Sharafi, Hossein Poustchi, Reza Malekzadeh, Yaser Mansoori, Mohammad Mehdi Naghizadeh, Mohammad Kazem Vakil, Azizallah Dehghan
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zahra Mohebi, Maryam Heidari Sarvestani, Zahra Moradi, Mohammad Mehdi Naghizadeh
Summary: This study examined the knowledge and attitude of female high school students in Fasa regarding breast cancer screening. The results showed that more than 87% of students had limited or incorrect information about breast cancer screening. Students had limited knowledge about the risk, symptoms, risk factors, and prevention strategies of breast cancer. It is recommended to implement educational programs in schools and encourage students to share information with their families to increase awareness in the society.
Review
Allergy
Zahra Salehi, Bibi Fatemeh Nobakht Motlagh Ghoochani, Yazdan Hasani Nourian, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei
Summary: The effects of nicotine and cigarette smoke on various diseases, including COVID-19 infection, are being discussed. Current data suggests that smokers have a higher risk of COVID-19 infection due to the overexpression of viral entry receptors. However, epidemiological reports indicate a lower incidence of COVID-19 in smokers. Nicotine has dual effects, both inflammatory and anti-inflammatory. The study investigates the effect of nicotine on various cells involved in COVID-19 infection.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Mostafa Ghanei, Ali Mohabattalab, Kiarash Fartash, Narjes Kolahchi, Alireza Khakdaman, Hooman Kaghazian, Abolfazl Bagheri
Summary: Widespread public vaccination is essential for ensuring health and preventing deaths, and the development of the COVID-19 vaccine exemplifies this. Vaccine development is a complex process that requires firm-level capabilities, infrastructure, long-term planning, and stable policies. With the global demand for vaccines during the pandemic, the national capability to produce vaccines is crucial. This paper examines factors at the firm and policy levels that influence the COVID-19 vaccine development process in Iran, drawing lessons for vaccine development in developing countries.
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2023)