Article
Biochemistry & Molecular Biology
Mi Seong Jo, Boo Wook Kim, Young Hun Kim, Jin Kwon Kim, Hoi Pin Kim, Jae Hoon Shin, Gun Ho Lee, Kangho Ahn, Mary Gulumian, Il Je Yu
Summary: The inhalation toxicity of carbon nanofibers (CNFs) is not well understood due to limited studies. This study examined the acute and short-term inhalation effects of CNFs on rats and found no noticeable toxicological responses. The findings suggest that CNFs do not pose significant risks in terms of inhalation toxicity.
Article
Biology
Alisa DeStefano, Clyde Martin, Andrew Huang, Dorothy Wallace
Summary: Inhalation of asbestos fibers leads to fatal diseases that manifest years later, and a mathematical model predicts accurate transport of fibers within the lymphatic system. The model suggests that fiber density in lymph nodes correlates with exposure levels, reaching steady state within five years after cessation of exposure.
BULLETIN OF MATHEMATICAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Ursula G. Sauer, Kai Werle, Hubert Waindok, Sabine Hirth, Oliver Hachmoller, Wendel Wohlleben
Summary: The study highlights the potential risk of inhaling man-made vitreous fibers and emphasizes the importance of abiotic dissolution testing in predicting biopersistence. Experimental results demonstrate the impact of fluid composition and binder on fiber dissolution rates, with recommendations made to enhance the reliability of predictions.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Sarah A. Valentino, Laetitia Chezeau, Carole Seidel, Sylvie Sebillaud, Mylene Lorcin, Monique Chalansonnet, Frederic Cosnier, Laurent Gate
Summary: This study aimed to compare the pulmonary toxicity of inhaled nanostructured aerosol of titanium dioxide (TiO2) between young and elderly rats. While there were differences in neutrophilic granulocytes influx and inflammation-related gene expression between the two age groups, slight variation was observed in physiological responses following TiO2 exposure. Age-related differences were mainly reflected in gene expression profiles, highlighting disrupted signaling pathways in rats based on their age.
Article
Environmental Sciences
Esther S. Lenssen, Raymond H. H. Pieters, Sandra M. Nijmeijer, Marieke Oldenwening, Kees Meliefste, Gerard Hoek
Summary: A study involving 16 healthy adult volunteers exposed to barbecue fumes outdoors showed that short-term exposure to air pollutants emitted from barbecuing was associated with a mild respiratory response in healthy young adults, including a prolonged increase in nasal IL8 levels without affecting lung function or other inflammatory markers.
ENVIRONMENTAL RESEARCH
(2022)
Article
Pediatrics
Hiroto Katami, Shingo Suzuki, Takayuki Fujii, Masaki Ueno, Aya Tanaka, Ken-ichi Ohta, Takanori Miki, Ryuichi Shimono
Summary: This study found that testicular torsion and reperfusion injury significantly decreased the expression of genes associated with spermatogenesis, which affected sperm production and function. This provides a basis for further exploring the impact of testicular torsion injury on fertility.
PEDIATRIC RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Basanth Babu Eedara, Rakesh Bastola, Shyamal C. Das
Summary: Dry powder inhalation therapy has been effective in treating localized lung diseases, but there is currently no standard method for evaluating the dissolution behavior of inhalable dry powder particles in the lungs.
Review
Clinical Neurology
Ahmad Toubasi, Thuraya N. Al-Sayegh
Summary: There is a strong correlation between short-term exposure to air pollutants and the occurrence and mortality rates of ischemic stroke. This highlights the importance of implementing policies to reduce air pollution.
Article
Computer Science, Interdisciplinary Applications
Xiaofeng Cheng, Chunan Tang
Summary: This study develops a unified numerical model to address short-term and long-term rock failures. By considering viscoelastic, viscoplastic, and damage mechanisms and integrating them under thermodynamic consistency, the model can reproduce and predict time-dependent failure behaviors of rocks.
COMPUTERS AND GEOTECHNICS
(2022)
Article
Engineering, Environmental
Soyeon Jeon, Wang Sik Lee, Kyung Seuk Song, Jiyoung Jeong, Sinuk Lee, Songyeon Kim, Gyuri Kim, Ji-Su Kim, Jinyoung Jeong, Wan-Seob Cho
Summary: The biotransformation and differential lung clearance kinetics of PEGylated silver nanoparticles (AgNP-PEGs) and PEGylated gold nanoparticles (AuNP-PEGs) were evaluated. The results showed that AgNP-PEGs were quickly dissolved and transformed into insoluble silver sulfide, while AuNP-PEGs were scarcely cleared or biotransformed in the lungs. The study highlights the importance of using the proteinase K digestion method for quantitative and qualitative evaluation of nanoparticle biotransformation and lung clearance kinetics.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Yurika Tokunaga, Hiroshi Okochi, Yuto Tani, Yasuhiro Niida, Toshio Tachibana, Kazuo Saigawa, Kinya Katayama, Sachiko Moriguchi, Takuya Kato, Shin-ichi Hayama
Summary: The study found microplastics in lung samples of wild birds, indicating that birds are also exposed to pollution by inhaling airborne microplastics. The results demonstrate that wild birds are exposed to microplastics not only through dietary sources but also through inhalation.
Article
Biochemistry & Molecular Biology
Lilian Juliana Lissner, Leticia Rodrigues, Krista Mineia Wartchow, Ederson Borba, Larissa Daniele Bobermin, Fernanda Urruth Fontella, Fernanda Hansen, Andre Quincozes-Santos, Diogo Onofre Gomes Souza, Carlos-Alberto Goncalves
Summary: This study found that injection of MG in rats led to decreased locomotor activity, anxiolytic effects, and impaired short and long-term memory and spatial memory. It also resulted in decreased hippocampal glutamate uptake, glutamine synthetase activity, and glutathione levels. The findings suggest that MG may contribute to brain dysfunction observed in diabetic patients and shed light on the role of astrocytes in disease and therapeutics.
NEUROCHEMICAL RESEARCH
(2021)
Article
Engineering, Geological
Kiseok Kim, Roman Y. Makhnenko
Summary: CO2 injection has a significant influence on the poroviscoelastic response of reservoir rock, particularly in terms of poroelastic and hydraulic properties. The treatment of CO2 increases the compressibility of the rock and induces chemical effects such as dissolution and stress corrosion cracking. Additionally, CO2 treatment facilitates viscous response and leads to increased permeability. Properly characterizing the time-dependent behavior is crucial for geologic storage projects.
ROCK MECHANICS AND ROCK ENGINEERING
(2022)
Article
Toxicology
D. Okhrimenko, J. A. Botner, H. K. Riis, M. Ceccato, M. Foss, M. Solvang
Summary: The biopersistence of fiber materials is crucial in assessing the potential health risks of inhalation. The dissolution rate of stone wool fibers depends on liquid composition, pH, reaction products transport, and fibers wetting properties. Presence of a sugar-based binder has no effect on the dissolution rate if fibers are wetted prior to the experiment.
TOXICOLOGY IN VITRO
(2022)
Article
Pharmacology & Pharmacy
Yushan Tian, Hongjuan Wang, Mingxia Wang, Xianmei Li, Fengjun Lu, Shuhao Ma, Wenming Wang, Jili Wang, Jiayou Tang, Jia Wu, Pengxia Feng, Yaning Fu, Shulei Han, Tong Liu, Huan Chen, Hongwei Hou, Qingyuan Hu
Summary: This study aimed to investigate the safety of xylitol inhalation for long-term use, and the NOAEL of xylitol in subchronic inhalation toxicological experiments for rats was determined to be 2.9 mg/L, indicating that long-term inhalation of xylitol is tolerable and safe for rats.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)