Article
Immunology
Yong Kwan Lim, Oh Joo Kweon, Hye Ryoun Kim, Tae-Hyoung Kim, Ah Ra Cho, Mi-Kyung Lee
Summary: The EuDxTM ufPCR Flu & RSV Detection Kit is a newly developed molecular assay for detecting influenza A/B and RSV simultaneously. The evaluation of this assay in a clinical setting has shown its excellent performance in diagnosing influenza A/B and RSV infections.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
A. Chamseddine, N. Soudani, Z. Kanafani, I Alameddine, G. Dbaibo, H. Zaraket, M. El-Fadel
Summary: The study found that influenza virus can be aerosolized beyond 1 meter in patient rooms, with distance and days after hospital admission influencing the positivity rate of the virus in air samples. Only three patients with RSV infection were recruited, and none of them were emitters.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Immunology
Bo Shu, Marie K. Kirby, William G. Davis, Christine Warnes, Jimma Liddell, Ji Liu, Kai-Hui Wu, Norman Hassell, Alvaro J. Benitez, Malania M. Wilson, Matthew W. Keller, Benjamin L. Rambo-Martin, Yamundow Camara, Jorn Winter, Rebecca J. Kondor, Bin Zhou, Stacey Spies, Laura E. Rose, Jonas M. Winchell, Brandi M. Limbago, David E. Wentworth, John R. Barnes
Summary: SARS-CoV-2 emerged in late 2019, causing symptoms similar to influenza viruses. The FDA granted emergency use authorization for a multiplex assay that can detect influenza A and B viruses, as well as SARS-CoV-2, increasing testing capacity and conserving resources.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Pathology
Thuy Phan, Ngoc Yen Kim Tran, Thomas Gottlieb, Steven Siarakas, Genevieve McKew
Summary: During the COVID-19 pandemic, sample pooling has been proven effective in increasing testing capacity and reducing reagent usage. This study evaluated the performance of influenza and RSV targets in the AusDiagnostics SARS-CoV-2, Influenza and RSV 8-well assay and investigated the impact of sample pooling on target detection. The results showed that sample pooling can improve testing efficiency and reduce reagent consumption.
Article
Environmental Sciences
Emalie K. Hayes, Madison T. Gouthro, Jason J. LeBlanc, Graham A. Gagnon
Summary: A multiplex RT-qPCR-based method was designed for simultaneous detection of influenza A, SARS-CoV-2, respiratory syncytial virus, and measles virus. The method had comparable sensitivity and linearity to monoplex assays. The assay's performance was validated in the field using wastewater and passive samples, showing accurate estimation of viral loads and suggesting potential improvement with more sensitive sampling methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Pathology
Robert Pell, S. Kim Suvarna, Nigel Cooper, Guy Rutty, Anna Green, Michael Osborn, Peter Johnson, Alison Hayward, Justine Durno, Theodore Estrin-Serlui, Marion Mafham, Ian S. D. Roberts
Summary: This UK multicentre study examined the disruption of healthcare services and excess mortality during the COVID-19 lockdown using coroners' autopsy reports. The study found that while a small number of deaths were directly attributed to COVID-19, delays in accessing medical care and the lockdown were potential factors contributing to death, particularly in cases of suicide and drug/alcohol-related deaths.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Xuexiang Lin, Xiao-Yu Liu, Bo Zhang, Ai-Qing Qin, Kwok-Min Hui, Kevin Shi, Yang Liu, Don Gabriel, X. James Li
Summary: A virus enzyme assay using a luciferin derivative as the substrate has been developed as an alternative method for detection of acute viral infection, particularly for influenza diagnosis. The assay showed similar detection rates for all influenza types and subtypes except for A(H7N9) due to lower viral titer. When tested with diluted specimens in comparison to a real-time polymerase chain reaction assay, the assay demonstrated high sensitivity and specificity.
SCIENTIFIC REPORTS
(2022)
Article
Virology
Marina Beretta Duarte, Tatiana Schaffer Gregianini, Leticia G. Martins, Ana Beatriz G. Veiga
Summary: This study investigated the epidemiology of IBV infection in Rio Grande do Sul, Brazil over 17 years, and found that IBV infection is associated with age and seasonality, with a high risk of severe infection. The research also highlighted that cardiopathy, metabolic disease, and smoking are risk factors for fatality in IBV infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Substance Abuse
Shane Darke, Johan Duflou, Amy Peacock, Michael Farrell, Julia Lappin
Summary: This study investigated the characteristics, circumstances of death, and autopsy findings of fatal heroin-related toxicity deaths in Australia from 2020 to 2022. The majority of cases were men in their 40s who were not enrolled in a drug treatment program and used multiple drugs. The findings also revealed significant autopsy findings such as acute bronchopneumonia and cardiomegaly.
Article
Immunology
Ching-Hao Hsu, Hsin-Pai Chen, Po-Liang Chen, Yu-Jiun Chan
Summary: This study described the characteristics and outcomes of lower respiratory tract infections associated with respiratory viruses in adults, finding that both influenza and non-influenza respiratory viruses were associated with increased mortality rates, with shock and acute kidney injury independently predicting a higher mortality rate.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Microbiology
Amar Aganovic
Summary: Research on the response of highly contagious enveloped viruses to alterations in their microenvironment has increased due to the SARS-CoV-2 pandemic and influenza epidemics. This review analyzes the pH-dependent viral structural changes during the endocytosis process for influenza A (IAV) and SARS coronaviruses. While there are similarities in the pH-regulated patterns leading to fusion, the mechanisms and pH activation differ.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Kieran Dee, Verena Schultz, Joanne Haney, Laura A. Bissett, Callum Magill, Pablo R. Murcia
Summary: Virus-virus interactions can impact the infection dynamics of respiratory viruses. In this study, 3-dimensional cultures of airway epithelium were used to show that SARS-CoV-2 replication is impaired in coinfections with influenza A or respiratory syncytial virus.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Rhiannon R. Penkert, Amanda P. Smith, Eike R. Hrincius, Jonathan A. McCullers, Peter Vogel, Amber M. Smith, Julia L. Hurwitz
Summary: The study demonstrated that vitamin A deficiency dysregulates the immune response, leading to a 100% mortality rate in influenza-infected VAD mice when exposed to secondary bacterial infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Genta Ito, Takahiro Takazono, Naoki Hosogaya, Naoki Iwanaga, Shogo Miyazawa, Satoki Fujita, Hideaki Watanabe, Hiroshi Mukae
Summary: This retrospective observational study evaluated the factors influencing the start date of the influenza epidemic season and the total number of infected persons per 1,000,000 population in 47 prefectures of Japan. Using a Japanese health insurance claims database, single and multiple regression analyses were conducted to assess the relationship between the start time of the epidemic and various factors such as absolute humidity, total visitors, and total population. The study found that the earlier the climate became suitable for virus transmission and the higher the human mobility, the earlier the epidemic season tended to begin.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Gareth R. Hardisty, Johanna A. Knipper, Alison Fulton, John Hopkins, Bernadette M. Dutia, Matthew D. Taylor
Summary: Pre-existing filarial infection can either ameliorate or worsen concurrent influenza infection, depending on the stage of filarial infection. Larval stage filarial infection can alleviate clinical symptoms of influenza infection, while patent infection reverses age-related resistance to influenza, resulting in more severe symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
David Anthony Foley, Linny Kimly Phuong, Joseph Peplinski, Selina Mei Lim, Wei Hao Lee, Asifa Farhat, Cara A. Minney-Smith, Andrew C. Martin, Ariel O. Mace, Chisha T. Sikazwe, Huong Le, Avram Levy, Tobias Hoeppner, Meredith L. Borland, Briony Hazelton, Hannah C. Moore, Christopher Blyth, Daniel K. Yeoh, Asha C. Bowen
Summary: Following a relative absence in winter 2020, there was a large resurgence of respiratory syncytial virus (RSV) detections during the 2020/2021 summer in Western Australia, linked to SARS-CoV-2 public health measures. The peak of RSV-positive admissions in 2020 was higher than in 2019, with older RSV-naive children being more affected. The increase in RSV-positive non-bronchiolitis admissions in 2020 raises concerns for regions with strict COVID-19 public health measures.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Letter
Pediatrics
David Anthony Foley, Linny Kimly Phuong, Joseph Peplinski, Selina Mei Jy Lim, Wei Hao Lee, Aoife Keane, Jessica Win See Wong, Cara A. Minney-Smith, Andrew C. Martin, Ariel O. Mace, Chisha T. Sikazwe, Huong Le, Avram Levy, Meredith Borland, Briony Hazelton, Hannah C. Moore, Christopher Blyth, Daniel Yeoh, Asha C. Bowen
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Public, Environmental & Occupational Health
Sera Ngeh, Florian Vogt, Chisha T. Sikazwe, Avram Levy, Nevada M. Pingault, David W. Smith, Paul Effler
Summary: This study identified substantial in-flight transmission of SARS-CoV-2 among passengers seated within and beyond two rows of primary cases. Factors such as seating proximity to primary cases and spending more than an hour in the arrival airport were independent predictors of secondary infection.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Multidisciplinary Sciences
John-Sebastian Eden, Chisha Sikazwe, Ruopeng Xie, Yi-Mo Deng, Sheena G. Sullivan, Alice Michie, Avram Levy, Elena Cutmore, Christopher C. Blyth, Philip N. Britton, Nigel Crawford, Xiaomin Dong, Dominic E. Dwyer, Kimberly M. Edwards, Bethany A. Horsburgh, David Foley, Karina Kennedy, Cara Minney-Smith, David Speers, Rachel L. Tulloch, Edward C. Holmes, Vijaykrishna Dhanasekaran, David W. Smith, Jen Kok, Ian G. Barr
Summary: Non-pharmaceutical interventions and travel restrictions for COVID-19 have impacted the circulation of respiratory viruses, including RSV. This study reports the resurgence of RSV in Australia following the lifting of some restrictions, and describes a reduction in genetic diversity in circulating RSV clades.
NATURE COMMUNICATIONS
(2022)
Article
Virology
David Anthony Foley, Chisha T. Sikazwe, Cara A. Minney-Smith, Timo Ernst, Hannah C. Moore, Mark P. Nicol, David W. Smith, Avram Levy, Christopher C. Blyth
Summary: Non-pharmaceutical interventions disrupted the seasonality of human metapneumovirus (hMPV) transmission, with an unusual resurgence observed in Western Australia in 2020. The incidence of hMPV in 2021 increased by 3-fold compared to previous years, with a greater than 4-fold increase in cases among children aged 1-4 years.
Article
Environmental Sciences
Avram Levy, Jake Gazeley, Terence Lee, Andrew Jardine, Cameron Gordon, Natalie Cooper, Richard Theobald, Clare Huppatz, Sandra Sjollema, Meredith Hodge, David Speers
Summary: Western Australia was mostly free of COVID-19 from March 2020 to 2022, with limited community transmission. However, genomic analysis of wastewater samples showed that even a small number of positive individuals could be used to identify the source of active cases and rule out transmission between different catchments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Infectious Diseases
Chisha Sikazwe, Matthew J. Neave, Alice Michie, Patrick Mileto, Jianning Wang, Natalie Cooper, Avram Levy, Allison Imrie, Robert W. Baird, Bart J. Currie, David Speers, John S. Mackenzie, David W. Smith, David T. Williams
Summary: This study reports the first detection of GIV Japanese encephalitis virus (JEV) in Australia, with a close phylogenetic relationship to the virus strains in Indonesia. The virus responsible for the fatal case in the Tiwi Islands is a divergent member of genotype IV (GIV) and shares high nucleotide identity with the 2022 Australian outbreak virus. The origin of this GIV lineage is estimated to have circulated in the region for several years prior to the Tiwi Islands case.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Computer Science, Interdisciplinary Applications
Qin Li, Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang
Summary: This study aims to develop a numerical model to investigate the effects of osteochondral junction leakage on cartilage lubrication. The results show that the permeability of the junction has a significant impact on cartilage lubrication, especially in the early stage of the disease. Increased leakage leads to a decrease in lubrication duration, shorter consolidation time, and an increase in the initial friction coefficient. These findings contribute to a better understanding of the development mechanism of cartilage disorders.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Infectious Diseases
Cara A. Minney-Smith, David A. Foley, Chisha T. Sikazwe, Avram Levy, David W. Smith
Summary: The seasonality of respiratory syncytial virus (RSV) in Western Australia (WA) is influenced by local climate. Before the SARS-CoV-2 pandemic, RSV seasons in the Metropolitan and Southern regions of WA were consistent in timing and intensity, while the Northern region did not experience a distinct seasonality.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Pediatrics
David A. Foley, Daniel K. Yeoh, Cara A. Minney-Smith, Christine Shin, Briony Hazelton, Tobias Hoeppner, Hannah C. Moore, Mark Nicol, Chisha Sikazwe, Meredith L. Borland, Avram Levy, Chris C. Blyth
Summary: The study examines the impact of a surge in hMPV cases on pediatric hospital admissions and the influence of changes in testing. Results show that hMPV-positive admissions in 2021 were significantly higher than the baseline period, particularly in children aged 1-4 years and those with other acute lower respiratory infection. The increase in testing contributed to the higher number of hMPV-positive cases, suggesting a genuine rise in hMPV infections.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter Richmond, Avram Levy, Kathryn Glass, Hannah C. Moore
Summary: Respiratory syncytial virus is a major cause of illness and death in infants worldwide. By analyzing pre-pandemic RSV testing data and hospital admission data, a statistical prediction model was used to estimate RSV-hospitalizations in infants under 1 year old. The highest incidence rate of RSV-hospitalization in infants under 6 months was found in those born in April/May.
Article
Immunology
Mohinder Sarna, Amanuel Gebremedhin, Peter C. Richmond, Kathryn Glass, Avram Levy, Hannah C. Moore
Summary: This study examined the association between sociodemographic and perinatal factors and childhood respiratory morbidity following early-life respiratory syncytial virus (RSV) infection. The results showed that in addition to preterm and young infants, children aged 12-<24 months could also be potential target groups for RSV prevention.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Health Care Sciences & Services
J. M. Basseal, C. M. Bennett, P. Collignon, B. J. Currie, D. N. Durrheim, J. Leask, E. S. McBryde, P. McIntyre, F. M. Russell, D. W. Smith, T. C. Sorrell, B. J. Marais
Summary: Australia avoided the worst effects of COVID-19 pandemic, but still faced negative impacts. Lessons from Australia's public health response include the effectiveness of movement restrictions with careful consideration of adverse impacts, the value of disease modeling while acknowledging its limitations, the need for timely national data for reassessment of surveillance structures, the utility of advanced pathogen genomics and novel vaccine technology, the importance of evidence-informed and consultative decisionmaking, addressing major weaknesses in the aged-care sector, adequate infection prevention and control frameworks, prioritizing the interests of young people, recognizing epidemics as a standing threat, and fostering regional and global solidarity.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)