IL-17A Alone Weakly Affects the Transcriptome of Intestinal Epithelial Cells but Strongly Modulates the TNF-α–induced Expression of Inflammatory Mediators and Inflammatory Bowel Disease Susceptibility Genes

Differential Regulation of Chemokines by IL-17 in Colonic Epithelial Cells

(2014) J. W. Lee et al.   JOURNAL OF IMMUNOLOGY

Meta-analysis using individual patient data: efficacy and durability of topical alicaforsen for the treatment of active ulcerative colitis

(2013) S. Vegter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Anti-TNF antibody-induced psoriasiform skin lesions in patients with inflammatory bowel disease are characterised by interferon-γ-expressing Th1 cells and IL-17A/IL-22-expressing Th17 cells and respond to anti-IL-12/IL-23 antibody treatment

(2013) Cornelia Tillack et al.   GUT

TNF-inducible expression of lymphotoxin-β in hepatic cells: An essential role for NF-κB and Ets1 transcription factors

(2012) Lily S. Subrata et al.   CYTOKINE

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of Severity of Coexisting Patellofemoral Disease With Increased Impairments and Functional Limitations in Patients With Knee Osteoarthritis

(2012) Shawn Farrokhi et al.   ARTHRITIS CARE & RESEARCH

IL-17-induced NF-κB Activation via CIKS/Act1

(2011) Søren Ulrik Sønder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

(2011) M. Roulis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†

(2010) Leo R. Fitzpatrick et al.   INFLAMMATORY BOWEL DISEASES

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10−/− mice

(2009) Jeremy S. Schaefer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

The G428A Nonsense Mutation in FUT2 Provides Strong but Not Absolute Protection against Symptomatic GII.4 Norovirus Infection

(2009) Beatrice Carlsson et al.   PLoS One

An overview of IL-17 function and signaling

(2008) Sarah L. Gaffen   CYTOKINE

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

The role of the novel Th17 cytokine IL-26 in intestinal inflammation

(2008) J Dambacher et al.   GUT

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES