Article
Gastroenterology & Hepatology
Markus F. Neurath, Michael Vieth
Summary: Mucosal healing is an important prognostic factor in the management of patients with inflammatory bowel disease. It can predict clinical remission and resection-free survival. There are two levels of mucosal healing: endoscopic healing and histological healing. Drug therapies and new techniques can have an impact on mucosal healing, but cannot provide a definitive cure.
Article
Medicine, General & Internal
Writaja Halder, Faidon-Marios Laskaratos, Hanan El-Mileik, Sergio Coda, Stevan Fox, Saswata Banerjee, Owen Epstein
Summary: The COVID-19 pandemic has heavily impacted healthcare services for patients with chronic diseases. This review explores the use of colon capsule endoscopy as a method for assessing and treating inflammatory bowel disease. Despite its limitations, there is increasing evidence to support the use of the second-generation colon capsule.
Article
Immunology
Masaya Yokoyama, Motoko Y. Kimura, Toshihiro Ito, Koji Hayashizaki, Yukihiro Endo, Yangsong Wang, Ryoji Yagi, Tomoo Nakagawa, Naoya Kato, Hisahiro Matsubara, Toshinori Nakayama
Summary: This study found that Myl9/12 were highly expressed in patients with inflammatory bowel disease and mice with DSS-induced colitis. Administration of anti-Myl9/12 Ab alleviated inflammation and prolonged survival, indicating Myl9/12 may be a new therapeutic target for patients with IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Soo-Young Na, Yun-Jeong Lim
Summary: Capsule endoscopy has proven to be valuable for diagnosing small bowel diseases, with utility in both CD and UC patients. While having a high diagnostic yield, CE is most cost effective as a third diagnostic test and has potential in the utility of CCE for colon diseases.
Review
Gastroenterology & Hepatology
Paulina Nunez, Noa Krugliak Cleveland, Rodrigo Quera, David T. Rubin
Summary: Endoscopic evaluation plays a crucial role in predicting disease activity and severity in inflammatory bowel diseases, with mucosal healing associated with improved clinical outcomes and incorporated into standard care. Therapeutic endoscopic options and surveillance strategies, including early detection of neoplasia, continue to advance with evolving technology and visualization techniques.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Medicine, General & Internal
Guanglin Cui, Qingbo Fan, Zhenfeng Li, Rasmus Goll, Jon Florholmen
Summary: This review discusses the use of TNF antibodies in treating IBD and the evaluation of therapeutic efficacy using current and novel biomarkers. It emphasizes the urgent need for validation and comparison studies of promising novel biomarkers to improve their value in clinical practice.
Article
Gastroenterology & Hepatology
Emir Tulumovic, Nermin Salkic, Denijal Tulumovic
Summary: A study was conducted to review the epidemiology of inflammatory bowel disease (IBD) in the Tuzla Canton of Bosnia-Herzegovina over a 10-year period. The findings showed that trends in the incidence and prevalence of IBD in the region were similar to Eastern European averages, although there were significant epidemiological differences within geographically close and demographically similar areas.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Reena Khanna, Christopher Ma, Vipul Jairath, Niels Vande Casteele, Guangyong Zou, Brian G. Feagan
Summary: Poor correlation between symptoms and active luminal inflammation has been established in patients with Crohn's disease and ulcerative colitis, leading to the use of endoscopic assessment. However, the current endoscopic indices used for evaluation are not completely validated and have limitations for clinical use.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sara Salvador-Martin, Bartosz Kaczmarczyk, Rebeca Alvarez, Victor Manuel Navas-Lopez, Carmen Gallego-Fernandez, Ana Moreno-Alvarez, Alfonso Solar-Boga, Cesar Sanchez, Mar Tolin, Marta Velasco, Rosana Munoz-Codoceo, Alejandro Rodriguez-Martinez, Concepcion A. Vayo, Ferran Bossacoma, Gemma Pujol-Muncunill, Maria J. Fobelo, Antonio Millan-Jimenez, Lorena Magallares, Eva Martinez-Ojinaga, Ines Loverdos, Francisco J. Eizaguirre, Jose A. Blanca-Garcia, Susana Clemente, Ruth Garcia-Romero, Vicente Merino-Bohorquez, Rafael Gonzalez de Caldas, Enrique Vazquez, Ana Dopazo, Maria Sanjurjo-Saez, Luis A. Lopez-Fernandez
Summary: This study identified overexpression of FCGR1A, FCGR1B, and GBP1 genes as potential pharmacogenomic markers of early response to anti-TNF agents in pediatric IBD patients.
Review
Medicine, General & Internal
Jack West, Katrina Tan, Jalpa Devi, Finlay Macrae, Britt Christensen, Jonathan P. Segal
Summary: There is a significant difference between symptomatology and disease activity in patients with inflammatory bowel disease (IBD), and treatment based solely on symptoms may not change the course of the disease significantly. The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative published the STRIDE-II position statement in 2021, which provides the most recent recommendations for a treat-to-target (T2T) approach in IBD. However, there are limitations and challenges to implementing the T2T approach in real-world clinical practice, including a lack of standardized definition for mucosal healing (MH) and limited evidence of achieving MH with a T2T approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Aravind Gokul Tamilarasan, Yvonne Tran, Sudarshan Paramsothy, Rupert Leong
Summary: Capsule endoscopy has a comparable diagnostic yield to colonoscopy and magnetic resonance enterography in Crohn's disease, but there are difficulties in standardizing scoring systems and lack of transmural assessment. In ulcerative colitis, capsule endoscopy has excellent sensitivity and positive predictive value, but it lacks histologic assessment and has poor specificity.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Eladio Rodriguez-Diaz, Qin Huang, Sandra R. Cerda, Michael J. O'Brien, Irving J. Bigio, Satish K. Singh
GASTROINTESTINAL ENDOSCOPY
(2015)
Article
Clinical Neurology
Shailendra Joshi, Rajinder P. Singh-Moon, Jason A. Ellis, Durba B. Chaudhuri, Mei Wang, Roberto Reif, Jeffrey N. Bruce, Irving J. Bigio, Robert M. Straubinger
Article
Biochemical Research Methods
Ali H. Badreddine, Kurt J. Schoener, Irving J. Bigio
BIOMEDICAL OPTICS EXPRESS
(2015)
Article
Biochemical Research Methods
Joseph Angelo, Christina R. Vargas, Bernard T. Lee, Irving J. Bigio, Sylvain Gioux
JOURNAL OF BIOMEDICAL OPTICS
(2016)
Article
Oncology
Jason A. Ellis, Johann Cooke, Rajinder P. Singh-Moon, Mei Wang, Jeffrey N. Bruce, Charles W. Emala, Irving J. Bigio, Shailendra Joshi
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Oncology
Juliane Nguyen, Johann R. N. Cooke, Jason A. Ellis, Michael Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M. Straubinger, Shailendra Joshi
JOURNAL OF NEURO-ONCOLOGY
(2016)
Article
Biochemical Research Methods
Ali H. Badreddine, Tomas Jordan, Irving J. Bigio
BIOMEDICAL OPTICS EXPRESS
(2016)
Article
Instruments & Instrumentation
Shailendra Joshi, Johann R. N. Cooke, Darren K. W. Chan, Jason A. Ellis, Shaolie S. Hossain, Rajinder P. Singh-Moon, Mei Wang, Irving J. Bigio, Jeffrey N. Bruce, Robert M. Straubinger
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2016)
Article
Oncology
Juliane Nguyen, Shaolie S. Hossain, Johann R. N. Cooke, Jason A. Ellis, Michael B. Deci, Charles W. Emala, Jeffrey N. Bruce, Irving J. Bigio, Robert M. Straubinger, Shailendra Joshi
JOURNAL OF NEURO-ONCOLOGY
(2017)
Article
Biochemical Research Methods
Katherine W. Calabro, Irving J. Bigio
JOURNAL OF BIOMEDICAL OPTICS
(2014)
Article
Neurosciences
Stefan Raufer, Cornelia Idoff, Aleksandrs Zosuls, Giacomo Marino, Nathan Blanke, Irving J. Bigio, Jennifer T. O'Malley, Barbara J. Burgess, Joseph B. Nadol, John J. Guinan, Hideko H. Nakajima
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2020)
Article
Oncology
Syeda Tabassum, Anup Tank, Fay Wang, Kavon Karrobi, Cameron Vergato, Irving J. Bigio, David J. Waxman, Darren Roblyer
Summary: Monitoring tumor response to treatment in real time using spatial frequency domain imaging (SFDI) shows promise as a noninvasive and label-free method to quantify changes in tissue optical scattering. This optical technique may serve as an early predictive biomarker of treatment response, outperforming traditional parameters such as tumor volume or functional parameters like oxygen saturation.
Article
Chemistry, Analytical
Uraib Sharaha, Eladio Rodriguez-Diaz, Klaris Riesenberg, Irving J. Bigio, Mahmoud Huleihel, Ahmad Salman
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Ahmad Salman, Uraib Sharaha, Eladio Rodriguez-Diaz, Elad Shufan, Klaris Riesenberg, Irving J. Bigio, Mahmoud Huleihel