Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Review
Biochemistry & Molecular Biology
Giulia Caioni, Angelo Viscido, Michele d'Angelo, Gloria Panella, Vanessa Castelli, Carmine Merola, Giuseppe Frieri, Giovanni Latella, Annamaria Cimini, Elisabetta Benedetti
Summary: The pathophysiological processes of inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, are not fully understood, but dysregulation of the gut immune system leading to overproduction of pro-inflammatory cytokines is a key factor. Both environmental and genetic factors are involved, with the microbiota playing a crucial role. PPARγ modulates interactions with environmental factors, and its impaired expression may represent a critical step in IBD pathogenesis, particularly in ulcerative colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Jinzhi Zhang, Jiao Nie, Min Zou, Qishan Zeng, Yue Feng, Zhenyi Luo, Huatian Gan
Summary: This study found that in patients with IBD, 61.9% of women reported SD and 43.5% of men reported ED, which are significantly higher than in healthy controls. The main factors associated with SD in women were anxiety and active perianal disease, while in men, age, depression, and active perianal disease were the main factors associated with ED.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Mohammed Hasosah, Wafaa Alhashmi, Renad Abualsaud, Anas Alamoudi, Afnan Aljawad, Mariam Tunkar, Nooran Felemban, Ahmed Basalim, Muhammad Khan, Aziz Alanazi, Ali Almehaidib
Summary: This study investigates environmental risk factors for inflammatory bowel disease (IBD) in the Saudi population. The results suggest that vaginal delivery, age above 10 years, deficient fruit intake, low physical activity, exposure to antibiotics, appendectomy, and frequent gastroenteritis admissions are associated with an increased risk of IBD.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili
Summary: In this prospective study, it was found that dietary and lifestyle risk factors for inflammatory bowel disease may differ according to disease phenotype.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Samuel Tanner, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Gregory Cooper, Emad Mansoor
Summary: This article examines the prevalence of inflammatory bowel disease in patients with gastritis, duodenitis, and peptic ulcer disease, taking into consideration the presence of Helicobacter pylori infection. It is found that inflammatory bowel disease is less common in patients with H. pylori, and there is no increased risk of developing IBD after undergoing H. pylori eradication therapy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Kimberley W. J. van der Sloot, Paul Geertsema, Hanneke C. Rijkmans, Michiel D. Voskuil, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Behrooz Z. Alizadeh, Gerard Dijkstra
Summary: This study identified 16 environmental factors associated with biological use and surgery in established IBD patients, providing important insights for further research on biological pathways, risk stratification, personalized interventions, and preventive strategies in IBD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Mohammad Reza Hatamnejad, Shaghayegh Baradaran Ghavami, Marzieh Shirvani, Mona Asghari Ahmadabad, Shabnam Shahrokh, Maryam Farmani, Ghazal Sherkat, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
Summary: IBD is a chronic inflammatory disease that poses a growing health problem. The use of anti-depressants as a routine regimen for IBD patients is not officially approved, but some physicians prescribe them empirically to alleviate symptoms. However, the prescription of SSRIs may come with adverse effects such as sleep disturbances, and there is evidence suggesting that prolonged use of SSRIs can worsen the IBD course. Despite the need for further research, periodic prescriptions of SSRIs at monthly intervals may be recommended for IBD patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gian Paolo Caviglia, Giorgio Martini, Angelo Armandi, Chiara Rosso, Marta Vernero, Elisabetta Bugianesi, Marco Astegiano, Giorgio Maria Saracco, Davide Giuseppe Ribaldone
Summary: The study found that patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Alfred Yu Ting Chia, Gladys Wei Xin Ang, Anita Sook Yee Chan, Webber Chan, Timothy Kit Yeong Chong, Ying Ying Leung
Summary: Psoriatic arthritis is a chronic inflammatory disease often associated with psoriasis and joint manifestations. While advancements have been made in understanding the disease and developing new treatments, the diverse comorbidities of PsA continue to present a clinical challenge in patient management.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Lacey R. Lopez, Ju-Hyun Ahn, Tomaz Alves, Janelle C. Arthur
Summary: Inflammatory bowel disease (IBD) is a significant global health problem that involves chronic intestinal inflammation and severe comorbidities. Disease-associated alterations to the intestinal microbiota and microbial metabolites play a crucial role in IBD development. Understanding the microbial function in the context of IBD and characterizing disease-associated microbial metabolites are necessary for targeted treatment strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
M. P. Eugenicos, N. B. Ferreira
Summary: This review examined recent evidence on the impact of depression and anxiety on disease activity, relapse, and healthcare utilization in inflammatory bowel disease (IBD), highlighting the importance of assessing depression and anxiety in routine management of IBD patients. Developing more longitudinal research and randomized controlled trials will provide further insights into the role of mental health in IBD outcomes.
BRITISH MEDICAL BULLETIN
(2021)
Article
Gastroenterology & Hepatology
Mielle Michaux, Justin M. Chan, Luke Bergmann, Luis F. Chaves, Brian Klinkenberg, Kevan Jacobson
Summary: Geographical clusters of pediatric inflammatory bowel disease (PIBD) were identified in British Columbia, Canada. The study found associations between PIBD incidence and ethnicity and environmental factors. The study also identified novel risk factors, such as fine particulate matter pollution and agricultural petroleum oil.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Benjamin Langan Gordon, Jonathan S. Galati, Stevie Yang, Randy S. Longman, Dana Lukin, Ellen J. Scherl, Robert Battat
Summary: Vitamin C deficiency is common in patients with inflammatory bowel disease, especially in those with elevated inflammatory markers and penetrating disease.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
