Review
Medicine, General & Internal
Christian Bojarski, Maximilian Waldner, Timo Rath, Sebastian Schuermann, Markus F. F. Neurath, Raja Atreya, Britta Siegmund
Summary: High-definition endoscopy is crucial in the initial diagnosis of inflammatory bowel disease (IBD), helping to characterize inflammation and differentiate between ulcerative colitis and Crohn's disease. In addition to videoendoscopy, the use of dyes sprayed via a catheter can improve detection rates of intraepithelial neoplasia. Virtual chromoendoscopy techniques should not be the sole surveillance strategy in IBD, while the results of oral methylene blue formulation show promise in increasing acceptance rates of classic chromoendoscopy.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Irene Zammarchi, Giovanni Santacroce, Marietta Iacucci
Summary: Endoscopic healing is an important treatment goal in Inflammatory Bowel Disease (IBD), but it may not reflect histological remission. New advanced techniques in IBD assessment and management have improved the accuracy of endoscopy in assessing vascular and mucosal features and detecting IBD-related dysplasia. The integration of artificial intelligence (AI) shows promise in addressing the challenge of interobserver variability. Molecular endoscopy is still in its early stages but offers potential for predicting response to therapy. This review discusses the contribution of advanced endoscopic techniques and their integration with AI in improving disease assessment, lesion detection, and outcome prediction in IBD management.
Review
Gastroenterology & Hepatology
Partha Pal, Mohan Ramchandani, Rajendra Patel, Rupa Banerjee, Swathi Kanaganti, Rajesh Gupta, Manu Tandan, Duvvuru Nageshwar Reddy
Summary: Confocal laser endomicroscopy (CLE) and endocytoscopy (EC) are ultra-high definition imaging modalities that enable real-time histological assessment. Their role in current clinical decision making in inflammatory bowel disease management is not well defined.
DIGESTIVE ENDOSCOPY
(2023)
Review
Medicine, General & Internal
Tommaso Lorenzo Parigi, Elisabetta Mastrorocco, Leonardo Da Rio, Mariangela Allocca, Ferdinando D'Amico, Alessandra Zilli, Gionata Fiorino, Silvio Danese, Federica Furfaro
Summary: Endoscopy is essential for evaluating inflammatory bowel disease and monitoring colorectal cancer. Advances in virtual chromoendoscopy and artificial intelligence are reshaping the field, while tools like endocytoscopy and pCLE enhance inflammation and dysplasia assessment. The combination of pCLE and molecular labeling may lead to personalized medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Roberto Gabbiadini, Ferdinando D'Amico, Alessandro De Marco, Maria Terrin, Alessandra Zilli, Federica Furfaro, Mariangela Allocca, Gionata Fiorino, Silvio Danese
Summary: Patients with ulcerative colitis and Crohn's disease in the colon are at higher risk of colorectal cancer (CRC). Surveillance colonoscopy is recommended as it can detect early-stage CRC. Dye chromoendoscopy (DCE) has been considered the most effective technique for detecting dysplasia, but advancements in endoscopic technology like high-definition colonoscopes and dye-less virtual chromoendoscopy (VCE) could alter future practices.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Stefan Chiriac, Catalin Victor Sfarti, Horia Minea, Carol Stanciu, Camelia Cojocariu, Ana-Maria Singeap, Irina Girleanu, Tudor Cuciureanu, Oana Petrea, Laura Huiban, Cristina Maria Muzica, Sebastian Zenovia, Robert Nastasa, Remus Stafie, Adrian Rotaru, Ermina Stratina, Anca Trifan
Summary: Inflammatory bowel diseases (IBD) are increasingly prevalent globally. Current therapies aim to reduce mucosal inflammation and repair the intestinal barrier function. Intestinal permeability, which may be related to IBD disease activity, is receiving increased attention. Confocal laser endomicroscopy (CLE) allows visualization of histological abnormalities and targeted optical biopsies in IBD, and has been used to assess vascular permeability and epithelial barrier function. Evaluating the functional characteristics of the intestinal barrier with CLE can potentially select patients at risk of relapses and be included in future therapeutic strategies for IBD.
Article
Oncology
Yuna Kim, Hyunki Kim, Minkyu Jung, Sun Young Rha, Hyun Cheol Chung, Sang Kil Lee
Summary: The study suggests that probe-based confocal laser endomicroscopy (pCLE) is more accurate than white-light endoscopy (WLE) with magnifying narrow-band imaging (M-NBI) in diagnosing residual cancer in gastric cancer patients receiving chemotherapy. This highlights the potential significance of pCLE in confirming residual cancer presence and obtaining tissue samples.
Review
Medicine, General & Internal
Arianna Dal Buono, Roberto Gabbiadini, Federica Furfaro, Marjorie Argollo, Thais Viana Tavares Trigo, Alessandro Repici, Giulia Roda
Summary: In the era of treat-to-target, endoscopy plays a crucial role in assessing remission in IBD patients. High-definition endoscopic imaging and technologies like DCE have greatly enhanced the quality and precision of mucosal patterns, making endoscopy a valuable tool for surveillance in IBD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ji Eun Kim, Chang Wan Choi, Sung Noh Hong, Joo Hye Song, Eun Ran Kim, Dong Kyung Chang, Young-Ho Kim
Summary: High-definition (HD) endoscopy is recommended for detecting dysplasia in patients with ulcerative colitis (UC). Dye-spray chromoendoscopy (DCE) and narrow-band imaging (NBI) are common adjunctive techniques. This study evaluated the incremental detection ability of DCE and NBI added to HD-WLE in patients with long-standing extensive UC. HD-DCE improved the detection of SSAs/Ps, but not dysplasia.
Review
Gastroenterology & Hepatology
Giovanni Santacroce, Irene Zammarchi, Chin Kimg Tan, Gaetano Coppola, Rachel Varley, Subrata Ghosh, Marietta Iacucci
Summary: Several advanced imaging techniques, including dye-based and virtual chromoendoscopy, probe-based confocal laser endomicroscopy and endocytoscopy, have shown great potential in managing inflammatory bowel disease (IBD) patients. These techniques allow for a more precise evaluation of mucosal and vascular bowel surface, enabling better assessment of inflammation, predicting outcomes, and assisting in therapeutic decision-making. Artificial intelligence (AI) also plays a promising role in objective assessment and improving prediction of outcomes in IBD.
DIGESTIVE ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Olga Maria Nardone, Rosanna Cannatelli, Subrata Ghosh, Marietta Iacucci
Summary: Endoscopic remission is considered the ultimate long-term goal for treating inflammatory bowel disease. Advances in endoscopic techniques, such as virtual electronic chromoendoscopy, endocytoscope, and confocal laser endomicroscopy, provide more accurate assessments of the intestinal mucosa. Artificial Intelligence (AI) shows promise in revolutionizing IBD diagnosis and management. These new endoscopic tools, combined with AI, offer incredible opportunities for precision medicine in patients with IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Engineering, Electrical & Electronic
Isra Salaheldin Zog, Oguz Gurcuoglu, Ozgur Ozdemir, Mustafa Berke Yelten, Onur Ferhanoglu
Summary: This study presents the design, manufacturing, and characterization of a focus adjustment actuator for capsule endoscopy. The actuator utilizes electromagnetic actuation to achieve focusing and can provide high-resolution imaging at multiple depths. With further development, it has the potential to be used for optical biopsies in a clinical environment.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2023)
Review
Gastroenterology & Hepatology
Jouke J. H. Van der Laan, Anne M. Van der Waaij, Ruben Y. Gabriels, Eleonora A. M. Festen, Gerard Dijkstra, Wouter B. Nagengast
Summary: Advancements in enhanced and magnified endoscopy have improved assessment of ileocolonic mucosa in IBD. Implementing molecular imaging in endoscopy could help overcome clinical challenges by providing real-time in vivo view of targeted biomarkers. Label-free modalities may optimize mucosal healing and dysplasia detection in IBD patients.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Virginia Solitano, Ferdinando D'Amico, Mariangela Allocca, Gionata Fiorino, Alessandra Zilli, Laura Loy, Daniela Gilardi, Simona Radice, Carmen Correale, Silvio Danese, Laurent Peyrin-Biroulet, Federica Furfaro
Summary: Endoscopic evaluation plays a crucial role in the management of inflammatory bowel diseases, with a focus on achieving histological remission along with symptomatic and endoscopic remission. New diagnostic technologies, such as dye-less chromoendoscopy and molecular imaging, offer potential to improve the accuracy of evaluating disease activity and monitoring colorectal cancer. Integration of artificial intelligence systems and video capsule endoscopy are expected to further enhance the capabilities of endoscopic techniques in clinical practice.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Anna Chaber-Ciopinska, Dorota Kiprian, Paulina Wieszczy, Andrzej Bielasik, Marek Bugajski, Wladyslaw Januszewicz, Andrzej Jarzabski, Milena Niemiec, Andrzej Mroz, Andrzej Kawecki, Jaroslaw Regula, Michal F. Kaminski
Summary: This study compared the efficacy of narrow-band imaging (NBI) and Lugol chromoendoscopy in screening for esophageal neoplasia among patients with a history of treatment for head and neck squamous cell cancer (HNSCC). The results showed that NBI outperformed Lugol chromoendoscopy in terms of biopsy rate, examination time, and patient tolerance.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Letter
Gastroenterology & Hepatology
Joshua Quan, Christopher Ma, Remo Panaccione, Lindsay Hracs, Nastaran Sharifi, Michelle Herauf, Ante Makovinovic, Stephanie Coward, Joseph W. Windsor, Lea Caplan, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric Benchimol, Gilaad G. Kaplan
Article
Gastroenterology & Hepatology
Bradley G. Goodyear, Faranak Heidari, Richard J. M. Ingram, Filomeno Cortese, Nastaran Sharifi, Gilaad G. Kaplan, Christopher Ma, Remo Panaccione, Keith A. Sharkey, Mark G. Swain
Summary: Magnetic resonance imaging revealed structural and functional changes within the brains of inflammatory bowel disease patients, in regions known to be involved in processing brain signals associated with behavioral symptoms, anxiety, pain, stress, and cognitive deficits.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
William J. Sandborn, Geert R. D'Haens, Bruce E. Sands, Remo Panaccione, Siew C. Ng, Nervin Lawendy, Nicole Kulisek, Irene Modesto, Xiang Guo, Rajiv Mundayat, Chinyu Su, Ivana Vranic, Julian Panes
Summary: This study provides a summary of tofacitinib safety in the treatment of ulcerative colitis. The results showed a low incidence of adverse events, with stable rates in patients treated for at least 7.8 years. The incidence rates of important safety events were generally below 2.0, except for herpes zoster.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Christopher Ma, Remo Panaccione, Yasi Xiao, Yuvan Khandelwal, Sanjay K. Murthy, Emily C. L. Wong, Neeraj Narula, Catherine Tsai, Farhad Peerani, Marica Reise-Filteau, Brian Bressler, Samantha Y. Starkey, Dustin Loomes, Rocio Sedano, Vipul Jairath, Talat Bessissow
Summary: This Canadian multicenter cohort study evaluated the real-world effectiveness and safety of tofacitinib for the treatment of ulcerative colitis (UC). The study found that one-third of UC patients achieved clinical remission with few serious adverse events. However, half of the patients lost response with dose de-escalation, highlighting the importance of counseling patients with negative prognostic factors about the risks and benefits of continuing high doses of tofacitinib.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael J. Buie, Stephanie Coward, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Lindsay Hracs, Christopher Ma, Remo Panaccione, Eric Benchimol, Charles N. Bernstein, Alain Bitton, Anthony R. Otley, Jennifer L. Jones, Sanjay K. Murthy, M. Ellen Kuenzig, Juan-Nicolas Pena-Sanchez, Laura E. Targownik, Harminder Singh, Antonio Avina-Zubieta, Gilaad G. Kaplan
Summary: Recent advances in IBD management have led to a decrease in hospitalization rates for IBD-related and non-IBD-related causes. The study observed a decline in all-cause hospitalization rates as well.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Florence-Damilola Odufalu, Marla C. Dubinsky, Laurent Peyrin-Biroulet, Karoliina Ylanne, Allyson Sipes, Joseph C. Cappelleri, Leo J. Russo, Michelle Segovia, Sean Gardiner, Edward P. Johnson, Amy Mulvey, Remo Panaccione
Summary: This study investigated the impact of patient demographics and psychological comorbidities on disease management and health care experience in patients with ulcerative colitis, highlighting the need for better understanding and improvement of patient care.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Jacinda Tran, Geert D'Haens, David T. Rubin, Nobuo Aoyama, Wen Zhou, Dapo Ilo, Xuan Yao, Yuri Sanchez Gonzalez, Remo Panaccione
Summary: This post hoc analysis evaluated the effects of upadacitinib on fatigue, bowel urgency, and abdominal pain in patients with ulcerative colitis. The results showed that upadacitinib induction treatment significantly reduced abdominal pain and bowel urgency, and also improved fatigue symptoms.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Harris A. Ahmad, James E. East, Remo Panaccione, Simon Travis, James B. Canavan, Keith Usiskin, Michael F. Byrne
Summary: Artificial intelligence has the potential to improve clinical research in inflammatory bowel disease endoscopy. It can enhance the efficiency and accuracy of assessing endoscopic activity in patients with inflammatory bowel disease and the impact of therapeutic interventions. This review discusses the current state of endoscopic assessment in inflammatory bowel disease clinical trials, highlighting the potential for artificial intelligence to transform the current paradigm and suggesting steps for implementation. By incorporating artificial intelligence into quality evaluation and patient progress monitoring, precision endoscopy and clinical trial recruitment in inflammatory bowel disease can be advanced.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Eric B. Collins, Gil Y. Melmed, Severine Vermeire, Silvio Danese, Peter D. R. Higgins, Christina S. Kwon, Wen Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, Si-Tien Wang
Summary: Indirect evidence suggests that Upadacitinib may be more effective than other advanced therapies in achieving clinical response, clinical remission, and endoscopic response in patients with moderately to severely active ulcerative colitis over a one-year period, with similar safety profiles across different therapies.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Jamie M. Horrigan, Edouard Louis, Antonino Spinelli, Simon Travis, Bjorn Moum, Jessica Salwen-Deremer, Jonas Halfvarson, Remo Panaccione, Marla C. Dubinsky, Pia Munkholm, Corey A. Siegel
Summary: This study investigated the global use and barriers to using patient-reported outcomes (PROs) in clinical practice for inflammatory bowel disease (IBD). The majority of healthcare providers use PROs in clinical practice, but there are variations in which PROs are used and how they influence management. Barriers to using PROs include lack of familiarity, integration issues, and time constraints. Education about PROs and the use of an accepted set of PROs can help overcome these barriers and achieve global harmonization.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Remo Panaccione, Maria T. Abreu, David T. Rubin, Subrata Ghosh, Axel Dignass, Anita Afzali, Douglas C. Wolf, Michael Chiorean, Severine Vermeire, Anjali Jain, Lorna Charles, Garrett Lawlor, Mark T. Osterman, Hsiuanlin Wu, James B. Canavan, Annkatrin Petersen, Jean-Frederic Colombel, Miguel Regueiro
Summary: This interim analysis examines the efficacy and safety of ozanimod treatment in patients with ulcerative colitis over a period of approximately 3 years. The results show that a high percentage of patients maintain clinical and mucosal efficacy during the treatment. No new safety concerns arise from long-term use of ozanimod.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Marc Ferrante, Peter M. Irving, Maria T. Abreu, Jeffrey Axler, Xiang Gao, Qian Cao, Toshimitsu Fujii, Astrid Rausch, Joana Torres, Ezequiel Neimark, Alexandra Song, Kori Wallace, Kristina Kligys, Sofie Berg, Xiaomei Liao, Qing Zhou, Jasmina Kalabic, Brian Feagan, Remo Panaccione
Summary: This post-hoc analysis found that maintenance therapy with risankizumab can lead to durable improvement in clinical and endoscopic outcomes for patients with moderately to severely active Crohn's disease, achieving the treatment goals of durable clinical remission, endoscopic healing, and biomarker normalization.
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Panes, R. Panaccione, B. Sands, C. Gasink, C. Marano, T. Ma, T. Hoops
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Silvio Danese, Wen Zhou, Justin Klaff, Dapo Ilo, Xuan Yao, Gweneth Levy, Peter D. R. Higgins, Edward V. Loftus Jr, Su Chen, Yuri Sanchez Gonzalez, Carolyn Leonard, Xavier Hebuterne, James O. Lindsay, Qian Cao, Hiroshi Nakase, Jean-Frederic Colombel, Severine Vermeire
Summary: Upadacitinib demonstrates efficacy and safety for 16-week induction and 52-week maintenance therapy in patients with moderately to severely active ulcerative colitis. Patients without clinical response after 8 weeks' upadacitinib 45 mg induction therapy may benefit from an additional 8 weeks of therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Correction
Gastroenterology & Hepatology
William J. Sandborn, Geert R. D'Haens, Bruce E. Sands, Remo Panaccione, Siew C. Ng, Nervin Lawendy, Nicole Kulisek, Irene Modesto, Xiang Guo, Rajiv Mundayat, Chinyu Su, Ivana Vranic, Julian Panes
JOURNAL OF CROHNS & COLITIS
(2023)
