Article
Gastroenterology & Hepatology
Hamed Khalili, Jordan E. Axelrad, Bjorn Roelstraete, Ola Olen, Mauro D'Amato, Jonas F. Ludvigsson
Summary: The study reveals that gastrointestinal infections are associated with an increased risk of microscopic colitis, especially Clostridioides difficile. The association between gastrointestinal infections and risk of MC is stronger for the collagenous subtype.
Review
Pathology
Lin Yuan, Tsung-Teh Wu, Lizhi Zhang
Summary: Microscopic colitis (MC) is a chronic inflammatory disease of the colon characterized by chronic, watery, nonbloody diarrhea and normal or almost normal endoscopic findings. Two main subtypes of MC, lymphocytic colitis (LC) and collagenous colitis (CC), are identified through microscopic examination on colon biopsy. The pathogenesis of MC is still unclear, but it has been associated with various risk factors and other diseases such as celiac disease, inflammatory bowel disease, and medication use. This paper aims to provide a systematic introduction to the clinicopathologic features of MC, focusing on unusual features and associations with other conditions.
Article
Gastroenterology & Hepatology
Johanna Kristina Larsson, Spencer Clarkson, Klas Sjoberg
Summary: The incidence of microscopic colitis (MC) has been increasing in the southern region of Sweden over the past decades. This study aimed to determine the incidence of lymphocytic colitis (LC) and collagenous colitis (CC) in the county of Skane during the period of 2010-2020, with a focus on temporal and spatial variations. The diagnosis of MC was retrieved from biopsy registries, and established diagnostic criteria were used. The study identified 1985 patients, with stable incidence of CC and a significant increase in the incidence of LC, particularly in the northwest region of Skane.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Emese Mihaly, Arpad Patai, Zsolt Tulassay
Summary: Microscopic colitis (MC) is increasingly recognized, but there are still many unanswered questions regarding its pathogenesis, diagnosis, and therapy. The relationship between microbiome changes, different subtypes of the disease, and the effectiveness of treatments like budesonide and biologics remain unclear, highlighting the need for further research in the future.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Amnon Sonnenberg, Robert M. Genta
Summary: The study revealed transitions between LC and CC in MC patients, as well as between MC and IBD. Gastroenterologists should consider underlying phenotype changes as a possible explanation for treatment failure in patients with either disease.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
June Tome, Kanika Sehgal, Amrit K. Kamboj, Bryce Comstock, W Scott Harmsen, Sahil Khanna, Darrell S. Pardi
Summary: The long-term use of budesonide in microscopic colitis appears to be effective and generally well tolerated with limited adverse effects.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Poornima Oruganti, Rehmat Awan, Xianzhong Ding, Michael Wesolowski, Ayokunle T. Abegunde
Summary: The study found that the majority of MC patients had CC, with TCAs use significantly increasing the odds of having LC compared to CC. Biopsies from repeat colonoscopies in some patients revealed changes in the pathological diagnoses, raising the question of interchangeability of MC.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Kanika Sehgal, June Tome, Amrit K. Kamboj, Ross A. Dierkhising, Darrell S. Pardi, Sahil Khanna
Summary: This retrospective study investigated histological changes in microscopic colitis and found that patients with lymphocytic colitis (LC) may have more histological changes compared to collagenous colitis (CC) patients. Additionally, the study suggests that the use of proton-pump inhibitors (PPIs), aspirin, and budesonide treatment may be associated with histological resolution.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
June Tome, Kanika Sehgal, Amrit K. Kamboj, William S. Harmsen, Patricia P. Kammer, Edward V. Loftus, William J. Tremaine, Sahil Khanna, Darrell S. Pardi
Summary: The study found that the incidence of MC and its subtypes remained stable between 2011 and 2019, but the prevalence was higher than in previous periods. The incidence of MC continues to be associated with increasing age and female sex.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yamile Zabana, Gian Tontini, Elisabeth Hultgren-Hornquist, Karolina Skonieczna-Zydecka, Giovanni Latella, Ann Elisabeth Ostvik, Wojciech Marlicz, Mauro D'Amato, Angel Arias, Stephan Mielhke, Andreas Munch, Fernando Fernandez-Banares, Alfredo J. Lucendo
Summary: This study is the first systematic review on the etiology of microscopic colitis (MC) supporting the notion that MC is a multifactorial disease. However, high-profile studies are lacking, and most evidence derives from small heterogeneous studies.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Gastroenterology & Hepatology
Yi-Hui Liu, Zhen Wu, Ji-Yuan Ding, Yu-Dan Shi
Summary: The study found that patients with microscopic colitis (MC) have a lower risk of colorectal adenoma or cancer compared to those without MC, supporting the recommendation that surveillance colonoscopy program is not necessary for MC patients.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pathology
Peter Johan Heiberg Engel, Anne-Marie Kanstrup Fiehn, Danny Goudkade, Jeppe Thagaard, Henrik Holten-Rossing, Stefania Landolfi, Vincenzo Villanacci, Lars Kristian Munck
Summary: Microscopic colitis (MC) encompasses lymphocytic colitis (LC) and collagenous colitis (CC). LC often presents with thickening of the subepithelial collagen band, while CC is characterized by an increased number of intraepithelial T-lymphocytes (IELs). The essential histopathological feature of MC is considered to be the lymphocytic inflammatory infiltration of the mucosa, although there is a non-linear correlation between the number of IELs and thickness of the collagenous band, indicating differences in their pathogenesis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
David Bergman, Bjorn Roelstraete, Jiangwei Sun, Fahim Ebrahimi, Johan Askling, Jonas F. Ludvigsson
Summary: A study found that there is an association between microscopic colitis (MC) and rheumatoid arthritis (RA), with MC patients being nearly twice as likely to develop RA compared to the general population. This study is important as it highlights the need for expedited evaluation for RA in MC patients presenting with joint symptoms and/or arthralgia, thus preventing delay in RA diagnosis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
David Bergman, Hamed Khalili, Bjorn Roelstraete, Jonas F. Ludvigsson
Summary: This study demonstrated a slight increase in cancer risk for patients with microscopic colitis, especially within the first year post-diagnosis. Microscopic colitis was associated with an increased risk of lymphoma and lung cancer, but a decreased risk of colorectal and gastrointestinal cancers.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Robert S. Sandler, Temitope O. Keku, John T. Woosley, Dale P. Sandler, Joseph A. Galanko, Anne F. Peery
Summary: Microscopic colitis, a leading cause of diarrhea in older adults, was found to have a lower prevalence in obese individuals, especially in women. Patients with microscopic colitis were more likely to experience weight loss after the onset of diarrhea, and the use of birth control pills was associated with a reduced risk of microscopic colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Xavier Molero, Juan Ramon Ayuso, Joaquim Balsells, Jaume Boadas, Juli Busquets, Anna Casteras, Mar Concepcion, Miriam Cuatrecasas, Gloria Fernandez Esparrach, Esther Fort, Francisco Garcia Borobia, Angels Gines, Lucas Ilzarbe, Carme Loras, Miquel Masachs, Xavier Merino, Jorge J. Olsina, Valenti Puig-Divi, Silvia Salord, Teresa Serrano, Eva Cristina Vaquero
Summary: Chronic pancreatitis is a serious condition that affects quality of life and is associated with high morbidity, complications, and mortality. The cost of healthcare for this condition is also high. Current guidelines for treatment are often based on limited scientific evidence, leading to vague recommendations. This position paper aims to provide clear position statements for clinicians based on a review of published literature and expert consensus, with the goal of promoting standardized terminology and rational diagnostic/therapeutic approaches.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Gastroenterology & Hepatology
Xavier Molero, Juan Ramon Ayuso, Joaquim Balsells, Jaume Boadas, Juli Busquets, Anna Casteras, Mar Concepcion, Miriam Cuatrecasas, Gloria Fernandez Esparrach, Esther Fort, Francisco Garcia Borobia, Angel Gines, Lucas Ilzarbe, Carme Loras, Miquel Masachs, Xavier Merino, Jorge J. Olsina, Valenti Puig-Divi, Silvia Salord, Teresa Serrano, Eva Cristina Vaquero
Summary: Chronic pancreatitis is a complex disease with diverse etiological factors and variable clinical presentations. Treatment options are wide-ranging, but recommendations are often vague or weak. This series of position papers aims to provide defined positions for clinicians based on updated research and expert consensus, with the goal of promoting the use of common terminology and rational diagnostic/therapeutic approaches.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Review
Nutrition & Dietetics
Fernando Fernandez-Banares
Summary: This review summarizes the recent advances in the possible role of carbohydrate maldigestion and dietary outcomes in patients with functional bowel disease. It found that there are no differences in the frequency of sugar malabsorption between patients with irritable bowel disease (IBS) and healthy controls, but the severity of symptoms after a sugar challenge is higher in patients. A low FODMAP diet is an effective treatment for global symptoms and abdominal pain in IBS.
Review
Gastroenterology & Hepatology
Saurabh Chandan, Banreet S. Dhindsa, Shahab R. Khan, Smit Deliwala, Lena L. Kassab, Babu P. Mohan, Ojasvini C. Chandan, Carme Loras, Bo Shen, Gursimran S. Kochhar
Summary: Endoscopic stenting in CD-related strictures is a safe technique with limited clinical success. Post-procedure abdominal pain and proximal stent migration are common adverse events reported.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Diego Casas-Deza, Luis Javier Lamuela-Calvo, Fernando Gomollon, Jose Miguel Arbones-Mainar, Berta Caballol, Javier P. Gisbert, Montserrat Rivero, Eugenia Sanchez-Rodriguez, Lara Arias Garcia, Ana Gutierrez Casbas, Olga Merino, Lucia Marquez, Viviana Laredo, Maria Dolores Martin-Arranz, Pilar Lopez Serrano, Sabino Riestra Menendez, Carlos Gonzalez-Munoza, Luisa de Castro Parga, Marta Calvo Moya, Esteban Fuentes-Valenzuela, Maria Esteve, Marisa Iborra, Miguel Dura Gil, Manuel Barreiro-De Acosta, Rufo Humberto Lorente-Poyatos, Noemi Mancenido, Margalida Calafat, Iago Rodriguez-Lago, Jordi Guardiola Capo, Maria Antonia Payeras, Victor Jair Morales Alvarado, Carlos Tardillo, Luis Bujanda, Jose Fernando Munoz-Nunez, Yolanda Ber Nieto, Fernando Bermejo, Pedro Almela, Merce Navarro-Llavat, Pilar Martinez Montiel, Cristina Rodriguez Gutierrez, Manuel Van Domselaar, Eva Sese, Teresa Martinez Perez, Elena Ricart, Maria Chaparro, Maria Jose Garcia, Antonio Lopez-Sanroman, Beatriz Sicilia, Beatriz Orts, Alicia Lopez-Garcia, Eduardo Martin-Larraz, Jose Lazaro Perez-Calle, Ruth de Francisco, Esther Garcia-Planella, Eugeni Domenech, Santiago Garcia-Loper
Summary: Ustekinumab shows similar effectiveness in elderly patients with CD as it does in non-elderly patients. The safety profile is also similar, except for a higher rate of de novo neoplasms in elderly patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Geriatrics & Gerontology
Laura Navarro, Alberto Gomez-Carballa, Sara Pischedda, Julian Montoto-Louzao, Sandra Viz-Lasheras, Alba Camino-Mera, Thomas Hinault, Federico Martinon-Torres, Antonio Salas
Summary: This study systematically reviewed the state-of-the-art of neuroscience and cognitive sciences research on music and Alzheimer's disease (AD) and found that music has beneficial effects on patients with neurodegenerative diseases, especially in memory and cognition. Transcriptomic and epigenomic data analysis also revealed connections between music-related genes and AD. These findings provide a new roadmap for genetic research and musical interventions in AD and other neurodegenerative conditions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Sergio Bazaga, Francisco Javier Garcia-Alonso, Jose Ramon Aparicio Tormo, Belen Martinez Moreno, Vicente Sanchiz, Carles Suria, Albert Garcia-Sumalla, Joan B. Gornals, Carlos Chavarria, Carme Loras, Francisco Jose Garcia-Fernandez, Alvaro Teran, Enrique Vazquez-Sequeiros, Rafael Pedraza Sanz, Leticia Perez-Carazo, Jose Carlos Subtil, Antonio Perez-Millan, Francisco Uceda Porta, Victoria Busto Bea, Carlos de la Serna-Higuera, Isabel Pinto Garcia, Juan Colan-Hernandez, Carlos Huertas, Carlos Guarner-Argente, Manuel Perez-Miranda
Summary: This study aimed to comprehensively assess the feasibility and safety of removing LAMS. The results showed that LAMS removal is safe and mostly requires basic endoscopic techniques. Referral to advanced endoscopy units should be considered for stents with known embedment or long indwell times, which may require more technically demanding procedures.
Article
Gastroenterology & Hepatology
Francesc Bas-Cutrina, Carme Loras, Albert Pardo, Raquel Ballester-Clau, Carlos Huertas, Carlos Guarner-Argente, Juan Colan-Hernandez, Claudia F. Consiglieri, Xavi Andujar, Ferran Gonzalez-Huix, Magdalena Vilanova-Serra, Laura Pardo-Grau, Sandra Maisterra, Pablo Ruiz-Ramirez, Albert Garcia-Sumalla, Cristian Tebe, Sebastia Videla, Joan B. Gornals
Summary: Endoscopic band ligation (EBL) combined with single-incision needle-knife (SINK) biopsy sampling appears to have a positive impact on the management of small gastrointestinal subepithelial tumors (SETs), particularly in SETs with a diameter of ≤10 mm.
GASTROINTESTINAL ENDOSCOPY
(2023)
Biographical-Item
Gastroenterology & Hepatology
Albert Martin-Cardona, Anna Carrasco, Maria Esteve
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Stiliano Maimaris, Suneil A. Raju, Olivia L. Green, Giulia Mantica, Amelie Therrien, David Flores-Marin, Justin Linden, Fernando Fernandez-Banares, Maria Esteve, Daniel Leffler, Federico Biagi, David S. Sanders
Summary: Objective Persistent villous atrophy (pVA), a condition where the intestinal lining remains damaged despite a gluten-free diet, has unclear significance in coeliac disease (CD). This study aimed to investigate the relationship between pVA and long-term outcomes and develop a scoring system to identify patients at risk of pVA. The results showed that patients with pVA had increased risk of complications and mortality. A 5-point score was developed to classify patients into low, intermediate, and high risk categories. Age at diagnosis, classic pattern of CD, lack of clinical response to GFD, and poor GFD adherence were identified as predictors for pVA.
Article
Medicine, Research & Experimental
Carme Loras, Pablo Ruiz-Ramirez, Juan Romero, Xavier Andujar, Josep Bargallo, Esther Bernardos, Marta Maia Bosca-Watts, Carlo Brugiotti, Eduard Brunet, David Busquets, Elena Cerrillo, Francisco Javier Cortina, Juan Antonio Diaz-Milanes, Carmen Duenas, Ramon Farres, Thomas Golda, Ferran Gonzalez-Huix, Joan B. Gornals, Jordi Guardiola, David Julia, Alba Lira, Jordina Llao, Miriam Manosa, Ingrid Marin, Monica Millan, David Monfort, David Moro, Josep Mullerat, Merce Navarro, Francisco Perez Roldan, Eva Pijoan, Vicente Pons, Jose Reyes, Maria Rufas, Empar Sainz, Vicente Sanchiz, Anna Serracant, Eva Sese, Cristina Soto, Jose Troya, Natividad Zaragoza, Cristian Tebe, Marta Paraira, Emma Sudria-Lopez, Vicenc Mayor, Fernando Fernandez-Banares, Maria Esteve
Summary: This study aims to compare the therapeutic efficacy of endoscopic and surgical treatments for de novo stenosis in Crohn's disease. The study will include 40 patients who will be randomly assigned to either the endoscopic or surgical treatment group, and their quality of life and treatment outcomes will be evaluated at 1-year follow-up.
Article
Biotechnology & Applied Microbiology
Antonio Salas, Irene Rivero-Calle, Federico Martinon-Torres
Summary: Vaccine hesitancy is considered a top global health threat by the WHO. This study investigates the ability of the AI chatbot ChatGPT to generate opinions on vaccine hesitancy by examining its response to prevalent false information, contraindications, and myths about vaccine safety circulating on the internet. The findings suggest that while ChatGPT's default responses may be incomplete, they are generally satisfactory and have the potential to guide users towards scientifically aligned information, though it cannot replace experts or scientific evidence itself.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Francesc Bas-Cutrina, Anna Casellas-Grau, Sebastia Videla, Carme Loras, Xavi Andujar, Francisco Luis Gil, Maica Galan, Fernando Fernandez-Aranda, Joao Carmezim, Joan B. Gornals
Summary: This study aimed to evaluate anxiety and carcinophobia in patients referred to specialized outpatient clinics for evaluation and treatment of minor nonspecific gastrointestinal sub-epithelial lesions. The study found that almost half of the patients presented with anxiety and/or carcinophobia, and specific associations with anxiety and fears were detected.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2023)
Article
Pharmacology & Pharmacy
Alberto Gomez-Carballa, Guillermo Albericio, Julian Montoto-Louzao, Patricia Perez, David Astorgano, Irene Rivero-Calle, Federico Martinon-Torres, Mariano Esteban, Antonio Salas, Juan Garcia-Arriaza
Summary: This study investigates the molecular mechanism of COVID-19 vaccines and their effects on the host response to SARS-CoV-2 infection. The findings suggest that one dose of MVA-S provides partial protection while two doses provide full protection against infection. The study also identifies key genes involved in viral control and immune response.
ANTIVIRAL RESEARCH
(2023)