Journal
INFLAMMATORY BOWEL DISEASES
Volume 16, Issue 11, Pages 1984-1992Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21280
Keywords
adaptive immune system in IBD; inflammation in IBD; complement; phagocyte
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Crohn's disease and ulcerative colitis are idiopathic chronic inflammatory diseases that primarily affect the gastrointestinal tract. The underlying causes remain poorly understood, but there is a growing body of evidence advocating a likely primary pathogenic role for immunodeficiency in the development of Crohn's lesions. Concordantly, a number of congenital immunodeficiencies disrupting the cellular innate immune system strongly predispose to noninfectious, Crohn's-like inflammatory bowel disease. There are case reports and series suggesting that the same may be true for some of the congenital adaptive and complement immunodeficiencies. This review considers and critiques these potential associations. (Inflamm Bowel Dis 2010:16:1984-1992)
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