Journal
INFLAMMATION RESEARCH
Volume 57, Issue 2, Pages 45-50Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00011-007-7110-6
Keywords
macrophage migratory inhibitory factor; macrophages; transplantation; inflammation; graft rejection
Categories
Ask authors/readers for more resources
Macrophage migration inhibitory factor (MIF) functions as a pleiotropic protein, participating in inflammatory and immune responses. MIF was originally discovered as a lymphokine involved in delayed hypersensitivity and various macrophage functions, including production of proinflammatory cytokines, glucocorticoid-induced immunomodulator, and natural killer cell inhibitory factor (NKIF), regulation of toll-like receptor expression, adherence and phagocytosis of macrophages, as well as induction of metalloproteinase. Therefore MIF is considered as a potential target protein in many pathophysiological states. In this review, considering the protein structure and the acting mechanisms of MIF, we mainly discuss the important role of MIF in pathogenesis of inflammatory diseases and graft rejection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available