Progranulin Promotes Regeneration of Inflammatory Periodontal Bone Defect in Rats via Anti-inflammation, Osteoclastogenic Inhibition, and Osteogenic Promotion

Progranulin is highly expressed in patients with chronic periodontitis and protects against experimental periodontitis in rats

(2018) Xiao Li et al.   JOURNAL OF PERIODONTOLOGY

Tumor necrosis factor-alpha inhibits osteogenic differentiation of pre-osteoblasts by downregulation of EphB4 signaling via activated nuclear factor-kappaB signaling pathway

(2017) L. M. Wang et al.   JOURNAL OF PERIODONTAL RESEARCH

EDC Cross-linking of Decellularized Tissue: A Promising Approach?

(2017) Nadine Lehmann et al.   TISSUE ENGINEERING PART A

Composite cell sheet for periodontal regeneration: crosstalk between different types of MSCs in cell sheet facilitates complex periodontal-like tissue regeneration

(2016) Hao Zhang et al.   Stem Cell Research & Therapy

Periodontal regeneration in swine after cell injection and cell sheet transplantation of human dental pulp stem cells following good manufacturing practice

(2016) Jingchao Hu et al.   Stem Cell Research & Therapy

TNF-α-induced NF-κB activation upregulates microRNA-150-3p and inhibits osteogenesis of mesenchymal stem cells by targeting β-catenin

(2016) Nan Wang et al.   Open Biology

Progranulin suppresses titanium particle induced inflammatory osteolysis by targeting TNFα signaling

(2016) Yun-peng Zhao et al.   Scientific Reports

Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice

(2015) Takaaki Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Primary prevention of periodontitis: managing gingivitis

(2015) Iain L. C. Chapple et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

High dose of TNF-α suppressed osteogenic differentiation of human dental pulp stem cells by activating the Wnt/β-catenin signaling

(2015) Zhenjie Qin et al.   JOURNAL OF MOLECULAR HISTOLOGY

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines

(2015) Chu-Fan Mo et al.   Stem Cell Research & Therapy

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Inflammatory and immune pathways in the pathogenesis of periodontal disease

(2013) Ali Cekici et al.   PERIODONTOLOGY 2000

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Dose-specific effects of tumor necrosis factor alpha on osteogenic differentiation of mesenchymal stem cells

(2011) H. Huang et al.   CELL PROLIFERATION

Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment

(2011) Ö Fentoğlu et al.   ORAL DISEASES

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

(2010) Jian Q. Feng et al.   FASEB JOURNAL

Destructive and Protective Roles of Cytokines in Periodontitis: A Re-appraisal from Host Defense and Tissue Destruction Viewpoints

(2010) G.P. Garlet   JOURNAL OF DENTAL RESEARCH

Mechanisms and control of pathologic bone loss in periodontitis

(2010) P. Mark Bartold et al.   PERIODONTOLOGY 2000

Direct bone formation during distraction osteogenesis does not require TNFα receptors and elevated serum TNFα fails to inhibit bone formation in TNFR1 deficient mice

(2009) Elizabeth C. Wahl et al.   BONE

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Periodontal disease and risk of atherosclerotic coronary heart disease

(2009) Takako Nakajima et al.   Odontology