Chikusetsusaponin V Inhibits LPS-Activated Inflammatory Responses via SIRT1/NF-κB Signaling Pathway in RAW264.7 Cells

The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway

(2016) Jiong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats

(2016) Dan Wan et al.   BRAIN RESEARCH BULLETIN

How much successful are the medicinal chemists in modulation of SIRT1: A critical review

(2016) Ashwani Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chikusetsusaponin V attenuates lipopolysaccharide-induced liver injury in mice

(2016) Yan Wen Dai et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice

(2016) Elena Talero et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibitory effects of SRT1720 on the apoptosis of rabbit chondrocytes by activating SIRT1 via p53/bax and NF-κB/PGC-1α pathways

(2016) Bi Liu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent

(2015) Lan-Di Sun et al.   BIOCHEMICAL PHARMACOLOGY

Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats

(2015) Hongdi Lv et al.   BRAIN RESEARCH BULLETIN

Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition

(2015) Sun Young Park et al.   NEUROSCIENCE LETTERS

Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability

(2015) HYUN-WOO KIM et al.   ONCOLOGY REPORTS

Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells

(2015) Sapna Singh et al.   TUMOR BIOLOGY

Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway

(2014) Jing Feng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Role of sirtuins in chronic obstructive pulmonary disease

(2014) Pusoon Chun   ARCHIVES OF PHARMACAL RESEARCH

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

(2014) Ying Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Role of SIRT1 in autoimmune demyelination and neurodegeneration

(2014) Alvaro Martin et al.   IMMUNOLOGIC RESEARCH

Chikusetsusaponin V inhibits inflammatory responses via NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages

(2014) Ting Wang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NF-κB signaling pathway

(2014) Qiang Peng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chikusetsu Saponin V Attenuates MPP+-Induced Neurotoxicity in SH-SY5Y Cells via Regulation of Sirt1/Mn-SOD and GRP78/Caspase-12 Pathways

(2014) Ding Yuan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dysregulated miR-34a–SIRT1–Acetyl p65 Axis Is a Potential Mediator of Immune Activation in the Colon during Chronic Simian Immunodeficiency Virus Infection of Rhesus Macaques

(2014) Mahesh Mohan et al.   JOURNAL OF IMMUNOLOGY

A RG-II Type Polysaccharide Purified from Aconitum coreanum Alleviates Lipopolysaccharide-Induced Inflammation by Inhibiting the NF-κB Signal Pathway

(2014) Xiaojun Li et al.   PLoS One

Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes

(2014) Roberto Risitano et al.   PLoS One

Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65

(2014) S. Shinozaki et al.   Science Signaling

Determination of chikusetsusaponin V and chikusetsusaponin IV in rat plasma by liquid chromatography-mass spectrometry and its application to a preliminary pharmacokinetic study

(2013) Dongli Qi et al.   BIOMEDICAL CHROMATOGRAPHY

Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy

(2013) BAOXIN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway

(2012) Wei Huang et al.   ACTA PHARMACOLOGICA SINICA

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chronic Inflammation Links Cardiovascular, Metabolic and Renal Diseases

(2011) Ichiro Manabe   CIRCULATION JOURNAL

Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

(2011) Sahdeo Prasad et al.   PREVENTIVE MEDICINE

Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines

(2009) Zheng Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY