Review
Immunology
Li Li, Yuan-Qiang Lu
Summary: HMGB1 is a crucial player in the inflammatory response and immunosuppression of sepsis, mediating the release of inflammatory factors and potentially contributing to the pathogenesis of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jun Zhang, Yujuan Liu, Lijun Liu
Summary: The study demonstrated that Hyp could alleviate impaired cardiac function and inflammation in sepsis-induced models, as well as decrease in cell viability and increase in inflammation in LPS-induced cardiomyocytes. Hyp significantly inhibited miR-21 expression in LPS-induced cardiomyocytes, and the protective influence of Hyp against sepsis-induced cardiac dysfunction was attenuated by miR-21 upregulation. These findings suggest that Hyp may serve as a promising natural drug for treating sepsis-associated cardiac dysfunction by regulating cardiomyocyte viability and inflammation through suppressing miR-21.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Zhuo Zeng, Yingying Lan, Yu Chen, Fangqing Zuo, Yali Gong, Gaoxing Luo, Yizhi Peng, Zhiqiang Yuan
Summary: This study demonstrates that GAS5 plays a crucial role in the regulation of inflammation induced by lipopolysaccharide (LPS). By modulating the miR-155-5p/SIRT1/HMGB1 axis, GAS5 suppresses inflammatory responses, offering a potential therapeutic target for sepsis inflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Zongmin Yu, Hu Yuan, Hao Chen, Ning Xie, Zhibin Wang, Qingyan Sun, Weidong Zhang
Summary: Novel Glycyrrhetinic Acid (GA) derivatives with fused heterocycles were designed and synthesized, showing potent anti-inflammatory effects. GA-60 exhibited stronger efficacy and higher affinity for HMGB1, as well as inhibiting various inflammatory mediators. These findings suggest that inhibiting HMGB1 release with fused heterocyclic GA derivatives is a promising strategy for sepsis treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Plant Sciences
Kai Sun, Jiahui Luo, Xingzhi Jing, Wei Xiang, Jiachao Guo, Xudong Yao, Shuang Liang, Fengjing Guo, Tao Xu
Summary: The study demonstrated that Hyperoside (Hyp) can inhibit IL-1 beta-induced apoptosis and inflammatory responses in chondrocytes, while regulating the expression of key proteins, suggesting its potential for the treatment of osteoarthritis.
Article
Biotechnology & Applied Microbiology
Jian Liu, Yadong Yang, Rong Lu, Qin Liu, Shukun Hong, Zhaolong Zhang, Guoxin Hu
Summary: The study confirmed that low expression of miR-381-3p in sepsis patients can be used as a marker for discrimination. MiR-381-3p restores the inflammatory response and myocardial dysfunction caused by sepsis via regulating HMGB1.
Article
Biochemistry & Molecular Biology
Nayeon Kim, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: CN can suppress excessive permeability induced by HMGB1 and improve vascular instability by inhibiting the release of HMGB1, leading to an increased survival rate in a mouse model of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yi-En Liao, Yongmei Xu, Katelyn Arnold, Fuming Zhang, Jine Li, Rani Sellers, Chaoyin Yin, Vijayakanth Pagadala, Anna Marie Inman, Robert J. Linhardt, Ding Xu, Rafal Pawlinski, Jian Liu
Summary: This study discovered that a synthetic heparan sulfate octadecasaccharide (18-mer) can effectively prevent sepsis and reduce related injuries and inflammation. The 18-mer inhibits the pro-inflammatory activity of histone H3 and HMGB1, while eliciting the anti-inflammatory effect of ApoA-I. By directly interacting with proteins, the 18-mer neutralizes cytotoxic histone H3 and separates HMGB1 and lipopolysaccharide complex, thereby reducing cell death and tissue damage in sepsis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Pharmacology & Pharmacy
Wonhwa Lee, Hui-Ji Choi, Hyunchae Sim, Samyeol Choo, Gyu Yong Song, Jong-Sup Bae
Summary: This study investigated the potential therapeutic effect of HCE on sepsis, finding that HCE can inhibit the release of HMGB1, reduce vascular hyperpermeability, alleviate HMGB1-mediated vascular disruptions, and decrease sepsis-related mortality and tissue injury in mice.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Chaisith Sivakorn, Jutamas Dechsanga, Lawan Jamjumrus, Kobporn Boonnak, Marcus J. Schultz, Arjen M. Dorndorp, Weerapong Phumratanaprapin, Ranistha Ratanarat, Thummaporn Naorungroj, Patchrapa Wattanawinitchai, Tanaya Siripoon, Chatnapa Duangdee, Tachpon Techarang
Summary: The study investigated prognostic biomarkers, HMGB1 and IL-6, at the time of admission in ICU for severe COVID-19 patients. Elevated levels of HMGB1 and IL-6 were associated with severity of illness and poor prognosis in these patients. Plasma HMGB1 and IL-6 levels at ICU admission may serve as prognostic biomarkers for critically ill COVID-19 patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Food Science & Technology
Yang Yang, Jia-Jie Huang, Gao-Sheng Zhu, Wei Hu
Summary: This study investigated the protective role of hyperoside in the development of osteoarthritis (OA) and its potential molecular mechanism. In vitro experiments demonstrated that hyperoside reversed IL-1 beta-induced secretion of proinflammatory mediators and extracellular matrix damage, possibly through inhibiting the PI3K/Akt and NF kappa B pathways. In a mouse model, hyperoside showed therapeutic effects in cartilage degeneration and pain symptoms. These findings suggest that hyperoside may be a promising treatment strategy for suppressing OA progression.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Roberta Vitali, Anna Barbara Mancuso, Francesca Palone, Claudio Pioli, Vincenzo Cesi, Anna Negroni, Salvatore Cucchiara, Salvatore Oliva, Claudia Carissimi, Ilaria Laudadio, Laura Stronati
Summary: It has been found that extracellular HMGB1 has a role in inflammatory disorders, including IBD. This study explored the relationship between HMGB1 and PARP1 in controlling intestinal inflammation. The results show that PARP1 promotes HMGB1 secretion in intestinal inflammation, and inhibiting PARP1 may be a new approach to manage IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P. Scicluna, W. Joost Wiersinga, Felipe A. Vieira Braga, Tom van der Poll
Summary: This study integrated single-cell data from patients with COVID-19, influenza, and non-infectious controls, revealing unique immune features in CAP patients caused by different pathogens, such as varied levels of NK cells and CD8 T EMRA cells.
Article
Biotechnology & Applied Microbiology
Quan Wen, Ngaikeung Lau, Huandi Weng, Peng Ye, Shaohui Du, Chun Li, Jianping Lv, Hui Li
Summary: This study demonstrated that chrysophanol has protective effects against lipopolysaccharide-induced acute lung injury (ALI) by regulating the HMGB1/NF-κB signaling pathway through HDAC3.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jaehong Kim, Samyeol Choo, Hyunchae Sim, Moon-Chang Baek, Jong-Sup Bae
Summary: The study demonstrated that Biapenem (BIPM) reduces vascular permeability and increases survival in a septic mouse model through inhibition of HMGB1 release. BIPM significantly suppresses HMGB1 release, inhibits vascular permeability, reduces inflammatory proteins, and decreases tissue injury markers.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Nayeon Kim, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: CN can suppress excessive permeability induced by HMGB1 and improve vascular instability by inhibiting the release of HMGB1, leading to an increased survival rate in a mouse model of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Soo Ho Ryu, Chaeyeong Kim, Nayeon Kim, Wonhwa Lee, Jong-Sup Bae
Summary: This study found that cornuside (CNS) effectively inhibits TGFBIp-mediated septic responses and reduces its lethality and pulmonary injury, suggesting that CNS may be used as a potential therapeutic agent for various vascular inflammatory diseases.
JOURNAL OF NATURAL MEDICINES
(2022)
Article
Chemistry, Multidisciplinary
Woojin Choi, Deokjae Heo, Taeho Kim, Sungwon Jung, Moonhyun Choi, Jiwoong Heo, Jae-Sung Kwon, Byeong-Su Kim, Wonhwa Lee, Won-Gun Koh, Jeong Ho Cho, Sangmin Lee, Jinkee Hong
Summary: The stress dissipation encoded silk fibroin electrode is proposed as the core electrode of wearable bioelectronics, which enables the elastoplasticity of the product. The harmony of elastoplastic core electrodes with shell fabrics ensures stable electrical response and mechanical performance, allowing the product to assist effective workouts and relieve muscular fatigue and severe injuries.
Article
Biotechnology & Applied Microbiology
Chaeyeong Kim, Soo Ho Ryu, Nayeon Kim, Wonhwa Lee, Jong-Sup Bae
Summary: SsnB can reduce renal functional damage caused by sepsis, decrease inflammatory response in the kidneys, and enhance the antioxidant defense system.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2022)
Article
Plant Sciences
Nayeon Kim, CheLynn Jeon, Chaeyeong Kim, Soo Ho Ryu, Wonhwa Lee, Jong-Sup Bae
Summary: This study found that SsnB has anti-inflammatory and antithrombotic activities. It prolongs clotting time, inhibits platelet aggregation and phosphorylation of phospholipase C, increases nitric oxide production, suppresses endothelin-1 secretion, and reduces factor Xa activity and platelet aggregation. SsnB injection also reduces thrombus formation and related mortality.
Article
Biotechnology & Applied Microbiology
Wonbeak Yoo, Wonhwa Lee, Hong Nam Kim, Jiyoung Jeong, Hee Ho Park, June Hong Ahn, Dana Jung, Juheon Lee, Ji-su Kim, Seung Whan Lee, Wan-Seob Cho, Seokho Kim
Summary: This study found that highly purified detonation-synthesized nanodiamonds can serve as a therapeutic agent for cytokine release syndrome (CRS) by adsorbing inflammatory cytokines. In an animal model, intravenous injection of DND samples significantly improved survival rates and reduced circulating inflammatory cytokines.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hyelim Kim, Boram Son, Eun U. Seo, Miji Kwon, June Hong Ahn, Heungsoo Shin, Gyu Yong Song, Eun Ji Park, Dong Hee Na, Seung-Woo Cho, Hong Nam Kim, Hee Ho Park, Wonhwa Lee
Summary: This article presents a strategy to continuously express therapeutic peptides on the surface of immune cells, using engineered T cells. These chimeric T cells can prevent vascular damage, suppress hypercytokinemia and lung tissue damages, demonstrating potential for treating severe infectious diseases.
Article
Pharmacology & Pharmacy
Soo Hyun Kim, Han Ju Yoo, Eun Ji Park, Wonhwa Lee, Dong Hee Na
Summary: The study demonstrated that in sodium acetate buffer, the thermal stability and aggregation propensity of IgG increase as buffer concentration decreases. The best stability and lower viscosity were observed in 10 mM sodium acetate buffer.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Correction
Biochemistry & Molecular Biology
Chun Gwon Park, Wonhwa Lee, Dong-Hyun Kim, Fangyuan Li, Wooram Park
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Chemistry, Physical
Deokjae Heo, Sungwon Jung, Jungbum Kim, Hyungseok Yong, Sohyeon Park, Dongchang Kim, Seoungeun Cho, Kyunghwan Cha, Hanwook Ryu, Youngho Jin, Wonhwa Lee, Sangmin Lee, Jinkee Hong
Summary: Alopecia is a common and distressing disease, and current treatments have limitations and side effects. This study introduces an innovative internal hair follicle stimulation system that uses human activity to stimulate hair follicles and promote hair regeneration without side effects.
Article
Chemistry, Multidisciplinary
Jae Woon Son, Jong Mun Son, Ki Ho Hur, Wonhwa Lee, Im-Sook Song, Dong Hee Na
Summary: The purpose of this study was to develop fibrinogen formulation using isothermal chemical denaturation (ICD) technique. 10 formulations of fibrinogen were initially prepared and screened via automated, high-throughput ICD measurements. The optimal formulation of fibrinogen was determined through osmolality measurements and accelerated stability study.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Biochemical Research Methods
Eunji Sung, Hyunchae Sim, Young-Chang Cho, Wonhwa Lee, Jong-Sup Bae, Minjia Tan, Sangkyu Lee
Summary: In this study, the authors identified acetylation and lactylation sites in Kupffer cells using global acylome technology. They found differences in the subcellular distributions and sequence motifs of modified proteins. Functional enrichment analyses provided insights into the roles of these modifications.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Nutrition & Dietetics
Hye-Jin Lee, Hui-Ji Choi, Sang-Ah Lee, Dong Hyuk Baek, Jong Beom Heo, Gyu Yong Song, Wonhwa Lee
Summary: Rare ginsenosides, specifically protopanaxatriol-type, can improve skeletal muscle atrophy by promoting myoblast differentiation and repair, and reducing the expression of muscle atrophy-related molecules.
Article
Materials Science, Multidisciplinary
Woojin Choi, Hyelim Kim, Taesuk Jun, Se Yong Jung, Du Yeol Ryu, Jae-Sung Kwon, Jihee Kim, Wonhwa Lee, Jinkee Hong
Summary: This study aims to establish an innovative therapeutic method, double-action disinfection, using silk fibroin gauze to prevent surgical site infections. The silk fibroin gauze exhibits good adhesive force and drug-elution rate, promoting disinfection of the surgical site and preventing infection-related complications. In clinical application, synergy with antibiotics significantly improves disease prognosis, demonstrating the potential clinical value of this therapeutic method.
ACS MATERIALS LETTERS
(2022)
Article
Pharmacology & Pharmacy
Wonhwa Lee, Ji-Eun Kim, Sumin Yang, Bong-Seon Lee, Soo-Hyun Cho, Jee-Hyun Lee, Ga-Eun Choi, Eui Kyun Park, Gyu-Yong Song, Jong-Sup Bae
Summary: The study found that RGX-365 can reduce the release of HMGB1 and decrease septic mortality, indicating its potential in the treatment of sepsis.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)