Article
Immunology
Erliang Kong, Yongchang Li, Xuqiang Geng, Jianxin Wang, Yan He, Xudong Feng
Summary: This study demonstrated that ischemic preconditioning (IPC) could protect against hepatic ischemia-reperfusion injury (HIRI) by activating autophagy and regulating endoplasmic reticulum stress (ERS)-dependent apoptosis in hepatocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Yi-Na Zhang, Qiong Wu, Nan-Nan Zhang, Hui-Sheng Chen
Summary: Ischemic preconditioning (IPC) can protect the blood-brain barrier (BBB) by interfering with glycocalyx, improving neurological pathology in rat models of cerebral ischemia-reperfusion injury (IRI).
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina
Summary: Remote ischemic preconditioning (RIPC) has been shown to protect various organs from ischemia-reperfusion injury, with glucocorticoids potentially playing a role in this protective effect. Studies demonstrated that RIPC reduced gastric erosion area in rats, and the involvement of glucocorticoids was confirmed through experiments with glucocorticoid inhibitors and receptor antagonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paramjit S. Tappia, Anureet K. Shah, Bram Ramjiawan, Naranjan S. Dhalla
Summary: Ischemia/reperfusion injury can compromise cardiac function recovery, but ischemic preconditioning (IP) can reduce oxidative stress and intracellular Ca2+ overload, improving cardiac function and providing cardioprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nantawit Sugandhavesa, Kasisin Klunklin, Siam Tongprasert, Patraporn Sitilertpisan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that ischemic preconditioning (IPC) can protect muscle strength after total knee arthroplasty (TKA) by enhancing mitochondrial fusion proteins and preventing I/R injury. Additionally, IPC significantly increased the expression of Mfn2 and Opa1 proteins, positively impacting postoperative muscle recovery.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Cell Biology
Yang Deng, Yunzhao Fu, Longxiang Sheng, Yixin Hu, Lishi Su, Jiawen Luo, Chun Yan, Wei Chi
Summary: Retinal ischemia can lead to retinal ganglion cell death and irreversible vision loss, with unclear pathogenic mechanisms. NLRC5 has been identified as a key regulator in microglial pyroptosis under ischemia conditions, potentially serving as a novel therapeutic target for ischemic retinopathy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Geetanjali Singh, Vibhav Varshney, Ahsas Goyal, Nemat Ali, Muzaffar Iqbal, Ishnoor Kaur, Celia Vargas-De-La-Cruz, Tapan Behl
Summary: The study found that chrysin enhances the therapeutic effect of ischemic preconditioning (IPC) in diabetic rat hearts via the PI3K-Akt-eNOS signaling pathway, reducing ischemia-reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Marco Moscarelli, Gianni D. Angelini, Costanza Emanueli, Saadeh Suleiman, Martino Pepe, Gaetano Contegiacomo, Prakash P. Punjabi
Summary: The study, based on multiple studies, confirmed the cardioprotective effect of RIPC on patients undergoing valve intervention, but did not observe improvement in post-operative clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yilong Zhao, Huajun Yang, Wei Shan, Anchen Guo, Qun Wang
Summary: Moderate ethanol preconditioning protects against ischemic brain injury by upregulating the expression of BKCa channels in rats.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Guangyu Zhang, Xiaoding Wang, Beverly A. Rothermel, Sergio Lavandero, Zhao Wang
Summary: Ischemic diseases, such as myocardial infarction and stroke, are among the deadliest and most disabling illnesses. The integrated stress response (ISR) plays a critical role in the pathogenesis and progression of ischemic diseases, making it a promising therapeutic target for alleviating symptoms and improving clinical outcomes of ischemic diseases such as ischemic heart disease, brain ischemia, ischemic liver disease, and ischemic kidney disease.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Medicine, General & Internal
Xinyao Tian, Yan Hu, Yuanxing Liu, Zhe Yang, Haiyang Xie, Lin Zhou, Shusen Zheng
Summary: The study utilized microarray to detect changes in circRNA and mRNA expression in response to hepatic ischemia-reperfusion injury and ischemic preconditioning intervention, identifying a potential target circRNA closely related to protective signaling. By constructing circRNA-miRNA-mRNA axes, the study revealed factors that may play a vital role in the protective mechanism of ischemic preconditioning.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Hao Zhou, Lin Li, Hao Sun, Hua Li, Yuxuan Wu, Xiaomin Zhang, Jinsong Zhang
Summary: The study demonstrates that remote ischemic preconditioning can alleviate secondary liver injury following hemorrhagic shock by activating autophagy, improving blood pressure adaptability, reducing lactate and aminotransferase levels, delaying the decrease in liver density, attenuating inflammatory response and apoptosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
