Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Biochemistry & Molecular Biology
Wenpeng Zhao, Zhaoju Deng, Herman W. Barkema, Maolin Xu, Jian Gao, Gang Liu, Yushan Lin, John P. Kastelic, Bo Han
Summary: Prototheca bovis infection induces inflammatory responses in mouse mammary gland tissue and mammary epithelial cells. The NF-kappa B/NLRP3 inflammasome pathway plays a crucial role in the inflammatory response, while scavenging ROS or activating Nrf2 can mitigate this response.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Lan Tsai, Ming-Kai Tsai, Yi-Giien Tsai, Yu-Chih Lin, Ya-Ling Hsu, Yi-Ting Chen, Yi-Ching Lin, Chih-Hsing Hung
Summary: This study investigated the effects of LTRAs on the expression of epithelium-derived cytokines in human airway epithelial cells and explored the underlying intracellular processes, including epigenetic regulation. It was found that LTRAs might induce the production of IL-25, IL-33, and TSLP by activating the MAPK and NF-kappa B pathways and regulating histone H3 acetylation and H3K36 and H3K79 trimethylation, exacerbating inflammation and asthma symptoms. Therefore, LTRA monotherapy may not be an appropriate therapeutic option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Xiao Ma, Manman Li, Guicong Lu, Ruihong Wang, Yunmin Wei, Yanfeng Guo, Yongxiong Yu, Caode Jiang
Summary: Epicatechin (EC) demonstrates significant anti-inflammatory, antioxidative, and anticancer properties, providing a new treatment option for mastitis in the dairy industry. Through in vivo and in vitro experiments, it was found that EC treatment effectively reduced expression of inflammatory mediators and cytokines, inhibited NF-kappa B and MAPK pathways, and modulated TMEM35A and TMPO proteins to alleviate LPS-induced inflammatory responses in bovine mammary epithelial cells and mouse mammary gland.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Food Science & Technology
Yu-Hsiang Yu, Yi-Han Lai, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng
Summary: The study reveals that DON induces inflammation in porcine intestinal epithelial cells (IPEC-J2) through phosphorylation of MAPK signaling pathways. However, co-treatment with DON and lipopolysaccharide (LPS) does not further enhance the expression of inflammation and tight junction-associated genes. Mycotoxin adsorbent agents can attenuate DON-induced inflammatory responses in IPEC-J2 cells by modulating the phosphorylation of p38, ERK, and JNK.
Article
Veterinary Sciences
Zhuo-Ma Luoreng, Da-Wei Wei, Xing-Ping Wang
Summary: Mastitis is a complex inflammatory disease in dairy cows caused by pathogenic infection, and miR-125b plays a crucial role in its occurrence and development. Downregulation of miR-125b can increase inflammatory factors production, while its upregulation can alleviate the inflammatory response.
VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hao-Yu Che, Chang-Hai Zhou, Chen-Chen Lyu, Yu Meng, Yun-Tong He, Hao-Qi Wang, Hong-Yu Wu, Jia-Bao Zhang, Bao Yuan
Summary: Dairy farming is an important economic activity, and mastitis is a common disease in dairy cows. Allicin, a natural extract from garlic, has various beneficial properties including anti-inflammatory and antibacterial effects. This study found that allicin can reduce inflammation in the mammary epithelial cells of dairy cows, possibly through the TLR4/NF-kappa B signaling pathway. Allicin may be a promising alternative treatment for mastitis in cows.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Shengyu Xu, Xiaojun Jiang, Yalei Liu, Xuemei Jiang, Lianqiang Che, Yan Lin, Yong Zhuo, Bin Feng, Zhengfeng Fang, Lun Hua, Jian Li, Jianping Wang, Zhihua Ren, Mengmeng Sun, De Wu
Summary: This study suggests that silibinin, a component of milk thistle, can reduce inflammatory responses and increase milk production in lactating sows. It exerts its effects by regulating the mTOR/NF-κB signaling pathway in porcine mammary epithelial cells. Silibinin may be a potential dietary strategy to alleviate inflammation in lactating sows.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Oncology
Oukseub Lee, Maarten C. Bosland, Minhua Wang, Ali Shidfar, Omid Hosseini, Xiaoling Xuei, Priyam Patel, Matthew J. Schipma, Irene Helenowski, J. Julie Kim, Susan E. Clare, Seema A. Khan
Summary: Results show that ulipristal acetate is the most effective among the selective progesterone receptor modulators studied, while mifepristone is ineffective and telapristone acetate is less effective. Ulipristal acetate reduces tumor incidence and delays tumor onset, and also affects gene expression in benign mammary glands.
Article
Dentistry, Oral Surgery & Medicine
Nergiz Bolat, Yalcin Erzurumlu, Halil Asci, Ozlem Ozmen, Bulem Ureyen Kaya
Summary: Selenium has a suppressive effect on experimentally induced rat periapical lesions, reducing bone destruction, inflammation severity, and regulating autophagic flux and p38 MAPK signaling.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Immunology
GuangWei Zhou, WuHao Zhang, HaoJie Wen, Qing Su, ZhongHua Hao, JingJing Liu, YingKui Gao, HuaQiang Zhang, Baoyan Ge, Chao Tong, XiuYuan He, XueBing Wang
Summary: This study found that esculetin (ESC) has a protective effect by significantly reducing inflammatory cell infiltration and the production of inflammatory cytokines, thus restoring normal mammary gland function and inhibiting the occurrence of mastitis.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Ming Kuang, Haitao Yu, Shiyan Qiao, Tao Huang, Jiaqi Zhang, Mingchao Sun, Xiumei Shi, Han Chen
Summary: The study evaluated the function of chitosan nanoparticle-peptide complexes (CNMs) in protecting against foodborne pathogen E. coli O157 infection. The CNMs exhibited excellent bactericidal activity against E. coli O157 without causing cytotoxicity or genotoxicity. Additionally, CNMs alleviated inflammation, improved antioxidant activity, and protected against E. coli O157-induced intestinal barrier damage, showing great potential as novel antimicrobial polymers in the food industry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Wei Huang, Chung-May Yang, Chang-Hao Yang
Summary: The study showed that FGF-1 has antioxidative and anti-inflammatory neuroprotective effects on high-glucose-induced retinal damage, reversing harmful effects of oxidative stress and inflammatory mediators. It can attenuate activation of p38 mitogen-activated protein kinase and nuclear factor-kappa B pathway, effectively preventing retinal injury in diabetes. The findings suggest potential for developing novel treatments for diabetic retinopathy by targeting oxidative stress and inflammatory signals in neuroretinal tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
