Article
Geriatrics & Gerontology
Betty Manrique-Espinoza, Rosa Palazuelos-Gonzalez, Victoria Pando-Robles, Oscar Rosas-Carrasco, Aaron Salinas-Rodriguez
Summary: This study analyzed the association between tumor necrosis factor-alpha (TNF-alpha), Interleukin-10 (IL-10), C-reactive protein (CRP) and physical performance in a sample of older adults in rural Mexico. The results showed a significant association between higher CRP levels and low physical performance, while IL-10 and TNF-alpha did not show a significant association.
Review
Food Science & Technology
Shanshan Hou, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Qiuhua Ji, Zhiying Fan, Zhihao Liu, Meitong Liu, Yan Yang
Summary: This meta-analysis examines the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators. The results show that CoQ10 can significantly reduce the levels of circulating CRP, IL-6, and TNF-a, and increase the concentration of circulating CoQ10. Daily supplementation of 300-400 mg CoQ10 is recommended for superior inhibition of inflammatory factors.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mitra Hariri, Bahareh Amirkalali, Hamid Reza Baradaran, Ali Gholami
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of parenteral selenium on inflammatory markers. The results revealed that parenteral selenium supplementation significantly reduced serum IL-6 levels but did not have a significant effect on CRP levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Oncology
Tim Schauer, Anne-Sophie Mazzoni, Anna Henriksson, Ingrid Demmelmaier, Sveinung Berntsen, Truls Raastad, Karin Nordin, Bente K. Pedersen, Jesper F. Christensen
Summary: The study compared the effects of high-intensity and low-to-moderate intensity exercise on inflammatory markers in cancer patients. Results showed significant increases of IL6, IL8, IL10, and TNFA post-treatment regardless of exercise intensity, with no difference for CRP or IL1B. In breast cancer patients, high-intensity exercise resulted in a lesser increase of CRP and TNFA.
ENDOCRINE-RELATED CANCER
(2021)
Article
Integrative & Complementary Medicine
Bethany Forseth, Michele Polfuss, Michael Brondino, Michael W. Lawlor, Margaret J. Beatka, Mariah J. Prom, Janis Eells, Jeri-Ann Lyons
Summary: Yoga participants had significantly lower scores in perceived stress and depression compared to non-yoga participants, but no significant differences in inflammatory markers were observed. Further research is needed.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2021)
Article
Biotechnology & Applied Microbiology
Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul Ain, Rabia Rasool, Muhammad Asif, Nisreen Anfinan, Absarul Haque, Hina Alam, Sagheer Ahmed, Mohammad Hamid Hamdard
Summary: The study revealed significant increases in inflammatory and stress-related markers in patients with colon cancer, along with lower levels of antioxidants. This suggests that oxidative stress and lipid peroxidation play a crucial role in the development of colon cancer by influencing various signaling cascades and DNA modifications.
Review
Psychology, Multidisciplinary
Ya-Hai Wang, Jingwang Tan, Huan-Huan Zhou, Meng Cao, Yu Zou
Summary: This meta-analysis investigated the effects of long-term exercise training on inflammatory biomarkers in healthy subjects. The results showed that long-term exercise training led to a significant decrease in levels of interleukin-6, C-reactive protein, and tumor necrosis factor alpha. Subgroup analysis revealed that longer duration and moderate intensity exercise had greater anti-inflammatory effects. Meta-regression analysis found that the reduction in C-reactive protein levels was weakened with increasing exercise intensity.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Chiara Griseta, Petronilla Battista, Fabio Castellana, Isabella Colonna, Sabrina Sciarra, Roberta Zupo, Ilaria Bortone, Luisa Lampignano, Sarah Tirelli, Giuseppe Berardino, Anita Mollica, Madia Lozupone, Francesco Panza, Pietro Fiore, Brigida Minafra, Rodolfo Sardone
Summary: Growing evidence shows the impact of inflammation on brain aging and neurodegeneration. This study examines the connection between global cognitive function and executive function, and the inflammatory markers IL-6, CRP, and TNF-alpha. The study, which involved a population-based sample of older adults in Southern Italy, measured blood levels of IL-6, CRP, and TNF-alpha, as well as administered two neuropsychological tests. The results indicate that higher levels of IL-6 were associated with cognitive impairment in this population.
Article
Dermatology
Gospel Nwikue, Anna Olsson-Brown, Nourah Aboheimed, Vincent Yip, Carol Jolly, Andreea Luchian, Lorenzo Ressel, Anurag Sharma, Wilma Bergfeld, Shaheda Ahmed, Anne Dickinson, Munir Pirmohamed, Daniel F. Carr
Summary: Decreased HMGB1 expression in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is an early indicator of epidermal injury. Etanercept, an anti-tumor necrosis factor, is effective in treating SJS/TEN. This study characterized the release of HMGB1 by TNF-a and its modulation by etanercept. TNF-a induced HMGB1 release in keratinocyte cells through necroptosis and apoptosis. Skin explants exposed to TNF-a or SJS/TEN serum showed significant epidermal toxicity and HMGB1 release, which was attenuated by etanercept. Lower levels of epidermal HMGB1 were found in pre-blistered SJS/TEN patients compared to controls. Keratinocyte HMGB1 release, mostly driven by necroptosis, can be reduced by etanercept. Other cytokines and cytotoxic proteins also contribute to epidermal HMGB1 release. The skin explant model provides a potential platform for further mechanistic studies and targeted therapy screening for SJS/TEN.
JOURNAL OF DERMATOLOGY
(2023)
Article
Clinical Neurology
Xiao-Yan Chen, Ko Ling Chan, Camilla K. M. Lo, Frederick K. Ho, Wing Cheong Leung, Patrick Ip
Summary: This meta-analysis examined the association between childhood and adulthood victimization and inflammation, highlighting a significant positive correlation. The effect size was found to be small, with childhood victimization showing a stronger effect on inflammation compared to adulthood victimization. Prevention of childhood victimization may be necessary to reduce inflammatory responses.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Chun-Chun Chang, Shih-Yi Peng, Hao-Hsiang Tsao, Hsin-Ting Huang, Xing-Yan Lai, Hao-Jen Hsu, Shinn-Jong Jiang
Summary: This study investigated the anti-inflammatory ability of the multifunctional peptide KCF18 in regulating cytokine expression and inhibiting inflammatory responses, providing a new approach for the treatment of septic shock and multiple organ failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Nicola Veronese, Damiano Pizzol, Lee Smith, Ligia J. Dominguez, Mario Barbagallo
Summary: Magnesium supplementation may significantly reduce human inflammatory markers, particularly serum CRP and NO levels.
Article
Cell Biology
Bin Wen, Ying-ting Wei, Kui Zhao
Summary: The HMGB protein family, including HMGB1, HMGB2, HMGB3, and HMGB4, regulates DNA replication, transcription, recombination, and repair, and functions as cytokines mediating responses to infection, injury, and inflammation. Among them, HMGB3 plays a crucial role in regulating normal hematopoietic stem cells and its expression levels are closely related to leukemia development.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Cell Biology
Lanyi Wei, Wenrui Zhang, Yueyang Li, Jinghui Zhai
Summary: This review introduces how the signaling axis between SIRT1 and HMGB1 regulates inflammation-related responses and tumor occurrence. It explores upstream regulators and potential treatment methods for inflammatory responses. Additionally, it suggests that SIRT1 and HMGB1 may be potential targets for treating inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Feng Pan, Jing Tian, Flavia Cicuttini, Graeme Jones
Summary: IL-6 was independently associated with compartment-specific CV loss and worse pain trajectory, but TNF-alpha and CRP were not significantly associated. This suggests that components of inflammation are implicated in the pathogenesis of cartilage loss and developing a worse pain course.
Article
Gastroenterology & Hepatology
Makoto Nishikawa, Manabu Kinoshita, Yuji Morimoto, Takuya Ishikiriyama, Masahiro Nakashima, Hiroyuki Nakashima, Takeshi Ono, Shuhji Seki, Tomoyuki Moriya, Junji Yamamoto, Yoji Kishi
Summary: The study showed that LPS preconditioning significantly reduced liver metastasis of Colon26 cells in mice and prolonged survival after tumor inoculation. LPS preconditioning increased the proportions and number of liver NK cells and NKT cells and augmented their intracellular perforin and granzyme B expression, while reducing their intracellular expression of IFN-gamma.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Hematology
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Cong Liu, Zhixiong Ying, Amanda C. Foks, Jimmy F. P. Berbee, Ko Willems van Dijk, Patrick C. N. Rensen, Yanan Wang
Summary: Brown fat activation attenuates atherosclerosis development by accelerating triglyceride-rich lipoprotein turnover and stimulating reverse cholesterol transport via SRB1. Knockdown of hepatic SRB1 not only increases HDL-cholesterol levels but also reduces plasma triglyceride and non-HDL-cholesterol levels, which explains the reduction in atherosclerosis development. This study suggests that brown fat activation combined with SRB1 modulation could be a potential strategy to treat cardiovascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Manabu Kinoshita, Seigo Ito, Takuya Ishikiriyama, Kumiko Sekiguchi, Ryota Yamaguchi, Ryoichi Tsuruhara, Akihisa Matsuda, Kazuki Koiwa, Masahiro Nakashima, Hiroyuki Nakashima, Masao Miyashita, Shuhji Seki
Summary: Posttreatment with synthetic CRP effectively improves murine bacterial peritonitis by increasing survival rate, reducing viable bacterial counts in the liver, and enhancing the phagocytic activity of Kupffer cells.
JOURNAL OF INNATE IMMUNITY
(2021)
Article
Physiology
Seigo Ito, Masahiro Nakashima, Takuya Ishikiriyama, Hiroyuki Nakashima, Akira Yamagata, Toshihiko Imakiire, Manabu Kinoshita, Shuhji Seki, Hiroo Kumagai, Naoki Oshima
Summary: The study found that oral administration of L-carnitine can alleviate the symptoms of diabetic nephropathy. L-carnitine can reduce the level of mitochondrial reactive oxygen species and improve the expression of superoxide dismutase. It also lowers the circulating mitochondrial DNA content. Moreover, L-carnitine can reduce macrophage infiltration and suppress inflammation.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima
Summary: The study reveals that LXR alpha and LXR beta play essential roles in NKT cell-mediated immunity, such as cytokine production and hepatic antitumor activity, and are involved in NKT cell development in immune tissues, such as the thymus.
SCIENTIFIC REPORTS
(2021)
Article
Transplantation
Hiroyasu Goto, Shinichi Shoda, Hiroyuki Nakashima, Midori Noguchi, Toshihiko Imakiire, Naoki Ohshima, Manabu Kinoshita, Soichi Tomimatsu, Hiroo Kumagai
Summary: This study examined the epidemiology of heat-related illness and the relationship between urinary biomarkers and the severity of heat-related illness and kidney injury. The results showed that urinary L-FABP is effective in detecting heatstroke-induced acute kidney injury and severe heat-related illness, while urinary KIM-1 may be a valuable biomarker for heatstroke-induced AKI in terms of serum cystatin C.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Hiromi Miyazaki, Manabu Kinoshita, Hiroyuki Nakashima, Shingo Nakamura, Daizoh Saitoh
Summary: This study shows that administration of the PPAR gamma agonist, pioglitazone, can modulate the phenotype of Kupffer cells and improve the dysregulated immune response during post-burn bacterial infection. Pioglitazone enhances phagocytosis, bacterial clearance, and reduces inflammatory mediators in Kupffer cells, leading to improved survival in burned mice. These findings suggest that pioglitazone may be a potential therapeutic candidate for post-burn infectious complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Hiroyuki Nakashima, Manabu Kinoshita
Summary: The liver plays a crucial role in systemic immunity and defends against the spread of tumor cells. It contains a higher percentage of innate immune lymphocytes, such as NK and NKT cells, which eliminate malignant cells with their strong cytotoxic ability. These lymphocytes also initiate immune responses by adaptive immune cells, making them important contributors to systemic antitumor immunity. Understanding the mechanisms of these immune cells provides insight for tumor immunity research and potential clinical applications for cancer therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Hiroyuki Nakashima, Bradley M. Kearney, Azusa Kato, Hiromi Miyazaki, Seigo Ito, Masahiro Nakashima, Manabu Kinoshita
Summary: Liver macrophages play critical roles in the immune defense mechanisms of the body. F4/80(high) Kupffer cells are the main resident macrophages in the liver and are the first immune cells to encounter pathogens in the liver. F4/80(low) monocyte-derived macrophages are essential for modulating liver immune functions.
Article
Medicine, Research & Experimental
Enchen Zhou, Xiaoke Ge, Hiroyuki Nakashima, Rumei Li, Hendrik J. P. van der Zande, Cong Liu, Zhuang Li, Christoph Mueller, Franz Bracher, Yassene Mohammed, Jan Freark de Boer, Folkert Kuipers, Bruno Guigas, Christopher K. Glass, Patrick C. N. Rensen, Martin Giera, Yanan Wang
Summary: DHCR24 inhibition prevents the development of NAFLD/NASH without causing hyperlipidemia. SH42, a DHCR24 inhibitor, significantly increases desmosterol levels, reduces hepatic lipid content and steatosis, and decreases plasma fatty acid and cholesteryl ester concentrations. SH42 treatment also decreases liver collagen content and plasma alanine transaminase levels.
EMBO MOLECULAR MEDICINE
(2023)
Article
Hematology
Osamu Ishida, Kohsuke Hagisawa, Nozomu Yamanaka, Hiroyuki Nakashima, Bradley M. Kearney, Koji Tsutsumi, Shinji Takeoka, Manabu Kinoshita
Summary: This study investigated the safety of using H12-ADP-liposomes in patients who received platelet transfusion after cardiopulmonary bypass surgeries. The results showed that H12-ADP-liposomes did not cause abnormal coagulation, platelet activation, or platelet-leukocyte aggregation in these patients. Therefore, H12-ADP-liposomes could likely be safely used in these patients to provide hemostasis without causing considerable adverse reactions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cell Biology
Seigo Ito, Hiroyasu Goto, Keiko Tanoue, Kazuki Koiwai, Takuya Ishikiriyama, Bradley M. Kearney, Kazuma Mori, Masahiro Nakashima, Hiroyuki Nakashima, Hiroo Kumagai, Shuhji Seki, Manabu Kinoshita, Naoki Oshima
Summary: The mortality rate for AKI due to sepsis is high, and effective therapies are needed. Macrophages play a crucial role in clearing bacteria from vital organs, but excessive activation can lead to organ injury. The synthetic CRP peptide showed promising therapeutic efficacy by controlling the activation of kidney macrophages, reducing bacterial propagation, and alleviating septic AKI.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Physiology
Hiroyasu Goto, Masahiro Nakashima, Hiroyuki Nakashima, Midori Noguchi, Toshihiko Imakiire, Naoki Oshima, Manabu Kinoshita, Hiroo Kumagai
Summary: Heatstroke can cause kidney injury, which may progress to chronic kidney disease. Heat acclimation (HA) provides thermal tolerance but its protective effect on heat-induced kidney damage is unclear. This study demonstrated that HA can ameliorate heat stress-induced kidney tubular damage and fibrosis in mice. It also showed that HA enhances the expression of heat shock protein 70 and prevents changes in kidney resident macrophages, providing a potential explanation for the renoprotective effect of HA.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Immunology
Masahiro Nakashima, Manabu Kinoshita, Hiroyuki Nakashima, Azusa Kato, Kazuma Mori, Kazuki Koiwai, Nariyoshi Shinomiya, Shuhji Seki
Summary: Recent studies have shown that mammalian B cells can play a role in acquired immune responses by presenting derivative peptides to CD4(+) T cells without their own somatic hypermutation or isotype switching.
JOURNAL OF IMMUNOLOGY
(2022)