Article
Biochemistry & Molecular Biology
Anna Scanu, Roberto Luisetto, Francesca Oliviero, Francesca Galuppini, Vanni Lazzarin, Gianmaria Pennelli, Stefano Masiero, Leonardo Punzi
Summary: The study showed that BPI alone or in combination with HA can improve inflammation in animal models of CIA and crystal-induced inflammation. The combined use of BPI and HA resulted in greater improvement in both models compared to the administration of the substances alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Juan M. Cantet, Zhantao Yu, Agustin G. Rius
Summary: Animals exposed to elevated ambient temperature experience physiological changes such as redistribution of blood and decreased blood flow to splanchnic tissues, leading to metabolic adaptations and gut dysfunction, ultimately activating a systemic inflammatory response.
Article
Biochemistry & Molecular Biology
Mingzu Guo, Wenxi Xu, Yoshinari Yamamoto, Takuya Suzuki
Summary: The study found that curcumin can increase the expression of HSP70 in intestinal Caco-2 cells through transcriptional activation, possibly enhancing cell integrity. The effects of curcumin are regulated by various signaling pathways. This discovery is expected to contribute to a deeper understanding of the regulation of intestinal HSP70 by dietary components.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Guo-Feng Luo, Jun-Long Liang, Di-Wei Zheng, Ping Ji, Jia-Wei Wang, Wei-Hai Chen, Xian-Zheng Zhang
Summary: The combination of stress-activated signal inhibitors and hair-derived nanoparticles enhanced the effectiveness of photothermal therapy by blocking tumor cell growth and invasion.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Agriculture, Dairy & Animal Science
Francesco Perini, Filippo Cendron, Giacomo Rovelli, Cesare Castellini, Martino Cassandro, Emiliano Lasagna
Summary: New genomic tools have been used to assess molecular pathways involved in heat stress resistance in chickens. Local chicken breeds exhibit better resilience to heat stress. Heat stress can affect poultry productivity and meat quality, with native backyard chickens displaying greater adaptability to their environment.
Article
Physiology
Aaron R. Caldwell, Kentaro Oki, Shauna M. Ward, Jermaine A. Ward, Thomas A. Mayer, Mark L. Plamper, Michelle A. King, Lisa R. Leon
Summary: The study found that mice undergoing repeated exertional heat injuries within a week of an initial heat injury appear to have protective adaptations. During the second exertional heat injury, mice were able to run longer and sustain higher body temperatures before collapse. However, despite this increased resilience to heat, the mice undergoing a second exertional heat injury showed lower levels of corticosterone, FABP2, MIP-1b, MIP-2, and IP-10, indicating potential adaptive processes providing acute heat resilience to subsequent conditions.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Precious Adedayo Adesina, Itsuki Saeki, Yoshinari Yamamoto, Takuya Suzuki
Summary: Impaired integrity of the intestinal epithelium can lead to intestinal and extraintestinal diseases. Heat shock protein 70 (HSP70) plays a crucial role in maintaining intestinal homeostasis. This study investigates the molecular mechanisms behind the upregulation of HSP70 by n-butyrate, a major metabolite of the intestinal microbiota. The findings suggest that n-butyrate enhances HSP70 expression through the activation of heat shock factor 1 (HSF1) and AMP-activated protein kinase (AMPK) pathways.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Food Science & Technology
Abir Ben Bacha, Norah Al-Orf, Mona Alonazi, Ramesa Shafi Bhat, Afaf El-Ansary
Summary: This study demonstrates that probiotics can reduce apoptosis and neuroinflammation induced by propionic acid (PPA) by modulating gut function. In a hamster model, probiotics significantly decreased levels of apoptotic markers and inflammation markers, providing protection against brain damage.
FOOD SCIENCE & NUTRITION
(2021)
Article
Parasitology
Nancy A. Aguoru, Ruth S. Kirk, Anthony J. Walker
Summary: This study provides a detailed molecular bioinformatic analysis of heat shock proteins (HSPs) in the human parasitic blood fluke Schistosoma mansoni. The results reveal the classification, expression patterns, protein interactions, and phosphorylation sites of HSPs in different stages of the parasite's life cycle. The findings suggest that HSPs play important roles in parasite survival and development, and offer insights for future investigations and therapeutics development against schistosomiasis.
PARASITES & VECTORS
(2022)
Editorial Material
Cell Biology
Christopher M. Jakobson, Daniel F. Jarosz
Summary: Cells reorganize their contents into subcellular structures in response to stimuli, with new research showing that proteins interact with substrates to coordinate disassembly of cellular structures and directly sense the cellular energy state for adaptive reorganization.
NATURE CELL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Maham Israr, Nadia Naseem, Tasleem Akhtar, Usman Aftab, Muhammad Shoaib Zafar, Muhammad Asif Faheem, Muhammad Shahzad
Summary: This study found that nimbolide can attenuate rheumatoid arthritis by downregulating toll-like receptors and related expressions, reducing symptoms and inflammation. Nimbolide showed comparable effects to the standard drug piroxicam, suggesting its potential as a therapeutic candidate for rheumatoid arthritis.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cell Biology
Lin-Kun Bai, Ya-Zhen Su, Zong-Di Ning, Cheng-Qiang Zhang, Li-Yun Zhang, Gai-Lian Zhang
Summary: This article reviews the preparation, characteristics and research progress of different animal models for Psoriatic Arthritis (PsA). The experimental animals used to study PsA are mainly rodents, including mice and rats. The retrieved animal models were classified into spontaneous or genetic mutation, transgenic and induced animal models based on the different methods of preparing the models. These PsA animal models involve multiple pathogenesis, and have advantages and disadvantages in terms of lesion appearance, success rate in molding, and reproducibility.
INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Tsukumi Miwa, Hideki Taguchi
Summary: Research has shown that IbpA down-regulates the expression of multiple heat shock proteins (Hsps) by repressing the translation of the heat shock transcription factor sigma(32), and plays a crucial role in shutting down the heat shock response. These findings reveal an unknown role of IbpA in regulating the heat shock response at the translational level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Chemistry, Multidisciplinary
Ruby Gupta, Deepika Sharma
Summary: Magnetic hyperthermia-based cancer therapy (MHCT) shows promise for treating solid tumors, but limitations such as lack of precise temperature control and MNP distribution hinder its biomedical applications. Three-dimensional (3D) in vitro tumor models offer a better replication of in vivo conditions, enhancing the clinical relevance of MHCT studies.
NANOSCALE ADVANCES
(2021)
Article
Biochemistry & Molecular Biology
Xiao Svec, Hana Storkanova, Maja Spiritovia, Krystof Slaby, Sabina Oreska, Aneta Pekacova, Barbora Hermankova, Kristyna Bubova, Petr Cesak, Haya Khouri, Gulalai Amjad, Herman Mann, Martin Komarc, Karel Pavelka, Ladislav Senolt, Josef Zamecnik, Jiri Vencovsky, Michal Tomcik
Summary: This study evaluated the impact of exercise on plasma Hsp90 levels in patients with idiopathic inflammatory myopathies (IIM) and its association with muscle damage and inflammation. The findings suggest that exercise interventions can stabilize Hsp90 levels and are correlated with changes in various inflammatory cytokines/chemokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)