Journal
INFLAMMATION
Volume 32, Issue 4, Pages 211-217Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-009-9122-6
Keywords
CTB glycoprotein; IL-4; IFN-gamma; IL-1 beta; inflammation; HMC-1 cells; bisphenol A
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Funding
- Korea Research Foundation
- Korean Government [KRF-2008-521-C00167]
- National Research Foundation of Korea [핵06B2513] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Cudrania tricuspidata is one of the most omnipresent traditional herbal drugs for anti-inflammation and anti-tumor. The purpose of the present study was to determine whether the CTB glycoprotein regulates the inflammatory reaction stimulated by bisphenol A (BPA) in human mast cells (HMC-1). Thus, we investigated that CTB glycoprotein inhibits the degranulation of histamine, expression of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), as a mitogen activated protein (MAP) kinase, nuclear transcription factors involving nuclear factor (NF)-kappa B and Activator protein (AP)-1, cyclooxygenase (COX)-2. The results indicated that CTB glycoprotein decreased gene expression of cytokines of IL-4, IFN-gamma, interleukin (IL)-1 beta and cyclooxygenase (COX)-2 in BPA-stimulated HMC-1 cells. Hence, we speculate that CTB glycoprotein can use as a potent anti-inflammatory agent for inflammatory allergic diseases.
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