Journal
INFLAMMATION
Volume 32, Issue 2, Pages 65-69Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-008-9103-1
Keywords
CC16; eosinophils; neutrophils; fMLF; PGD(2); migration
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Funding
- Swedish Research Council [K2002-745X-14455-01A]
- Swedish Foundation for Health Care Sciences and Allergy Research
- Cancer-och Allergifonden
- Swedish Asthma and Allergy Association
- Sahlgrenska Academy
- University of Gothenburg
- Frimurare Barnhusdirektionen
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Clara cell 16-kDa (CC16) is an anti-inflammatory protein chiefly produced in the lung epithelium. CC16 has been shown to inhibit the migration of rabbit neutrophils and human monocytes toward the formyl peptide N-formyl-methionine-leucin-phenylalanin (fMLF). Eosinophils migrate towards prostaglandin D2 (PGD(2)) and CC16 has been shown to bind to PGD(2). Therefore we investigated if CC16 could inhibit the migration of human eosinophils and neutrophils towards fMLF and/or PGD(2). Migration of eosinophils and neutrophils was assessed in a microplate migration system using specific ligands and receptor antagonists. CC16 inhibited the migration of eosinophils and neutrophils toward fMLF, which is likely to result from the interaction of CC16 with members of the formyl-peptide receptor family. However, CC16 did not inhibit eosinophil migration towards PGD(2). We therefore propose that CC16 may down-modulate the entry of human eosinophils and neutrophils into the airways during inflammation in the lung.
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