Review
Dermatology
S. Tso, F. Satchwell, H. Moiz, T. Hari, S. Dhariwal, R. Barlow, E. Forbat, H. Randeva, Y. T. Tan, A. Ilchyshyn, M. M. Kwok, T. M. Barber, C. Thind, A. C. Y. Tso
Summary: Erythroderma, a cutaneous inflammatory state with skin barrier and metabolic dysfunctions, has an estimated annual incidence of 1-2 per 100,000 in Europe with a male preponderance. While associated with a broad range of diseases, the majority of cases result from pre-existing chronic dermatoses.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Review
Endocrinology & Metabolism
Ling Zhan, Hong-fang Feng, Han-qing Liu, Lian-tao Guo, Chuang Chen, Xiao-li Yao, Sheng-rong Sun
Summary: ICIs, a group of drugs used in treating malignant tumors, block negative co-stimulatory molecules to reactivate the immune system's ability to recognize and kill tumors, but this may also lead to immune-related adverse events, including thyroid dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Katarina Ogrinc, Sergio A. Hernandez, Misa Korva, Petra Bogovic, Tereza Rojko, Lara Lusa, Geena Chiumento, Franc Strle, Klemen Strle
Summary: Meningoradiculoneuritis is a distinct clinical entity with unique immune and genetic pathophysiology, characterized by elevated levels of B-cell and T-cell chemokines, as well as increased frequency of TLR1-1805GG polymorphism and constitutional symptoms.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Dermatology
Ana I. Rodriguez Bandera, Deshan F. Sebaratnam, Orli Wargon, Li-Chuen F. Wong
Summary: Infantile hemangioma (IH) is the most common pediatric vascular tumor, with poorly understood pathogenesis thought to involve aberrant response of pluripotent stem cells. IH typically appears in the first few weeks of life and follows a characteristic trajectory of proliferation and involution, with clinical appearance depending on depth and distribution.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Oncology
Natalia Kremenevski, Michael Buchfelder, Nirjhar Hore
Summary: This review summarizes the epidemiology, histopathology with molecular biology, clinical presentation, diagnostic workup, and current treatment strategies with related clinical outcomes of intracranial germinomas. The findings suggest that intracranial germinomas respond well to radiotherapy, chemotherapy, or a combination of both, and have very high cure and survival rates. Early discrimination of germinomas from other intracranial neoplasms contributes to the reduction of morbidity and mortality.
CURRENT ONCOLOGY REPORTS
(2023)
Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Review
Dermatology
Ana Preda-Naumescu, Hana N. Ahmed, Tiffany T. Mayo, Nabiha Yusuf
Summary: Hidradenitis suppurativa is a chronic inflammatory skin condition with a range of symptoms, from painful nodules to abscesses, associated with various mechanisms and comorbidities. It significantly impairs patients' quality of life and requires early recognition and treatment.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Review
Clinical Neurology
Melissa A. Elafros, Henning Andersen, David L. Bennett, Masha G. Savelieff, Vijay Viswanathan, Brian C. Callaghan, Eva L. Feldman
Summary: Diabetic peripheral neuropathy is a common complication of diabetes, and early diagnosis and treatment are crucial for improving patients' quality of life. Hyperglycemia and metabolic syndrome are major risk factors for the development of diabetic peripheral neuropathy.
Article
Microbiology
Alice Raffetin, Julien Schemoul, Amal Chahour, Steve Nguala, Pauline Caraux-Paz, Giulia Paoletti, Anna Belkacem, Fernanda Medina, Catherine Fabre, Sebastien Gallien, Nicolas Vignier, Yoann Madec
Summary: By comparing the clinical features of patients with different diagnoses and identifying factors associated with recovery, our study found that a multidisciplinary team dedicated to suspicion of LB can provide more accurate diagnosis and better medical support, leading to clinical improvement and avoiding inappropriate antibiotic prescription.
Review
Clinical Neurology
Aneesh B. Singhal
Summary: Reversible cerebral vasoconstriction syndrome (RCVS) is a condition characterized by reversible narrowing of the intracranial arteries, predominantly affecting women. The main symptoms include recurrent severe headaches and abnormal brain imaging, which may lead to complications such as hemorrhage, ischemia, and edema. The pathophysiology is not yet fully understood, and treatment mainly focuses on symptomatic management and avoiding triggers.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Medicine, General & Internal
Gary P. Wormser, Donna McKenna, Tyler Morgan, Carol Scavarda, Denise Cooper, Paul Visintainer
Summary: This study assessed the presence and severity of symptoms in Lyme disease patients with extracutaneous manifestations (ECLD) in the US. There was no significant difference in symptom frequency between ECLD patients and Lyme disease patients with erythema migrans at baseline and 12 months. However, ECLD patients were significantly less likely to be Caucasian, suggesting that erythema migrans skin lesions may have been missed in individuals with darker skin.
AMERICAN JOURNAL OF MEDICINE
(2023)
Review
Dermatology
Gil Yosipovitch, Susan T. Nedorost, Jonathan I. Silverberg, Adam J. Friedman, Juliana M. Canosa, Amy Cha
Summary: Stasis dermatitis is a chronic inflammatory skin disease that mainly affects the lower extremities of older individuals. It is caused by venous reflux and can be challenging to diagnose due to its resemblance to other skin conditions and poor clinical recognition. Compression therapy, topical treatments, and interventional treatment options are the mainstays of treatment.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Microbiology
Kaitlyn N. Santiago, Tanya Kozlik, Elizabeth S. Liedhegner, Rebecca A. Slick, Michael W. Lawlor, Dean T. Nardelli
Summary: We investigated the effects of Treg cells on B. burgdorferi infection in BALB/c mice, which have a different immune response compared to C57BL/6 mice. Depletion of Treg cells before infection caused increased joint swelling at low infection doses, but did not significantly affect histopathology. Mice with higher borrelial load in their hearts and higher levels of serum interleukin-10 were observed when Treg cells were depleted before infection with a higher dose. Multiple animal models are necessary to understand the role of Treg cells in the host response to B. burgdorferi due to the variability in Lyme disease presentation in humans.
Article
Microbiology
Jiaru Yang, Shiyuan Wen, Jing Kong, Peng Yue, Wenjing Cao, Xin Xu, Yu Zhang, Jingjing Chen, Meixiao Liu, Yuxin Fan, Lisha Luo, Taigui Chen, Lianbao Li, Bingxue Li, Yan Dong, Suyi Luo, Guozhong Zhou, Aihua Liu, Fukai Bao
Summary: This study demonstrated the efficacy of oral amoxicillin, oral azithromycin, injectable ceftriaxone, and injectable cefotaxime for treating Lyme disease. Cefuroxime and penicillin were found to be safe for treating LD. Amoxicillin was effective for treating erythema migrans. However, no significant advantage of doxycycline in efficacy and safety for treating LD was observed.
MICROBIOLOGY SPECTRUM
(2021)
Article
Infectious Diseases
Clemence Corre, Guillaume Coiffier, Benoit Le Goff, Marine Ferreyra, Xavier Guennic, Solene Patrat-Delon, Brigitte Degeilh, Jean-David Albert, Pierre Tattevin
Summary: This observational retrospective multicentre study in Western France focused on characterizing Lyme arthritis, management, and outcome. The majority of patients with Lyme arthritis had monoarthritis, primarily affecting the knee. Treatment involved antibiotics, with some patients also receiving intra-articular glucocorticoid injections. Complete resolution of Lyme arthritis was seen in a significant proportion of patients with follow-up data.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Engineering, Biomedical
Dana T. Levy, Grace Y. Minamoto, Raphaella Da Silva, Yoram A. Puius, Naomi Peck, Daniel Goldstein, David D'Alessandro, Victoria A. Muggia
Meeting Abstract
Cardiac & Cardiovascular Systems
A. M. Shah, D. Sims, S. Madan, N. Siddiqi, A. Luke, O. Saeed, S. Patel, S. Murthy, J. Shin, S. Watts, W. Jakobleff, S. Forest, S. Vukelic, D. Belov, Y. Puius, G. Minamoto, V. Muggia, A. Carlese, S. Leung, M. Rahmanian, J. Leff, D. Goldstein, U. Jorde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. M. Shah, E. Ong, D. Sims, N. Siddiqi, A. Luke, O. Saeed, S. Patel, S. Murthy, J. Shin, S. Watts, W. Jakobleff, S. Forest, S. Vukelic, D. Belov, Y. Puius, G. Minamoto, V. Muggia, A. Carlese, S. Leung, M. Rahmanian, J. Leff, D. Goldstein, U. Jorde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2018)
Article
Immunology
Allison Kutner, Margaret Aldrich, Sarju Patel, Joann J. Kang, Bijal Amin, Ranon Mann, Ibne Karim M. Ali, Roosecelis Brasil Martines, Jennifer Rittenhouse Cope, Graciela O. De Boccardo, Yoram A. Puius
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Cardiac & Cardiovascular Systems
Snehal R. Patel, Shivank Madan, Omar Saeed, Daniel B. Sims, J. Julia Shin, Cecilia Nucci, Edward Borukhov, Doctor Y. Goldstein, William Jakobleff, Stephen Forest, Sasa Vukelic, Sandhya Murthy, John Reinus, Yoram Puius, Daniel J. Goldstein, Ulrich P. Jorde
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2018)
Article
Cardiac & Cardiovascular Systems
Ulrich P. Jorde, Aman M. Shah, Daniel. B. Sims, Shivank Madan, Nida Siddiqi, Anne Luke, Omar Saeed, Snehal R. Patel, Sandhya Murthy, Jooyoung Shin, Johanna Oviedo, Sade Watts, William Jakobleff, Stephen Forest, Sasa Vukelic, Dimitri Belov, Yoram Puius, Grace Minamoto, Victoria Muggia, Anthony Carlese, Sharon Leung, Marjan Rahmanian, Jonathan Leff, Daniel Goldstein
ANNALS OF THORACIC SURGERY
(2019)
Letter
Immunology
Orlando Quintero Cardona, Vagish S. Hemmige, Yoram A. Puius
TRANSPLANT INFECTIOUS DISEASE
(2020)
Review
Immunology
Yoram A. Puius, Rachel M. Bartash, Barry S. Zingman
Summary: The widespread use of facemasks has been crucial in controlling the SARS-CoV-2 pandemic, and it is suggested that continued masking after the pandemic can help protect vulnerable transplant recipients. Limited data on masking for infection prevention in transplant recipients highlights the need for further study and implementation of routine masking post-transplantation.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Medicine, General & Internal
Francesco Castagna, Xiaonan Xue, Omar Saeed, Rachna Kataria, Yoram A. Puius, Snehal R. Patel, Mario J. Garcia, Andrew D. Racine, Daniel B. Sims, Ulrich P. Jorde
Summary: This retrospective study analyzed the clinical characteristics, treatments, and outcomes of COVID-19 patients admitted to a hospital in New York City from March 1, 2020 to February 28, 2021. The results showed a decrease in inpatient mortality over the course of the pandemic, with an increase in the use of remdesivir, steroids, and anticoagulants, and a decrease in the use of hydroxychloroquine and other antibiotics. Multivariate analysis revealed that bed occupancy was associated with increased 30-day in-hospital mortality of COVID-19 patients.
Article
Engineering, Biomedical
Yoram A. Puius, Fauziya Parkar, Aileen P. Tlamsa, Justin A. Nistico, Victoria A. Muggia, Grace Y. Minamoto, Ulrich P. Jorde, Daniel J. Goldstein, Renee M. Moadel
Summary: Ga-SPECT-CT is an effective modality for determining the presence and extent of LVAD infections, leading to changes in management in over half of cases.
Meeting Abstract
Cardiac & Cardiovascular Systems
D. K. Phan, D. J. Goldstein, D. Chauhan, J. P. Skendelas, Y. Puius, D. Fauvel, M. Taveras, S. J. Forest
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Meeting Abstract
Hematology
Astha Thakkar, Zhu Cui, Stephen Zachary Peeke, Nishi Shah, Amanda Lombardo, Fariha Khatun, Jennat Mustafa, Alyssa De Castro, Kailyn Gillick, Felisha Joseph, Anjali Naik, Shafia Rahman, Angelica D'Aiello, Richard Elkind, Susan Sakalian, Karen Fehn, Karen Wright, Michelly Abreu, Latoya Townsend Nugent, Nicole Chambers, Rosmi Mathew, Donika Binakaj, Randin Nelson, Carlo Palesi, Monika Paroder, Joan Uehlinger, Yanhua Wang, Yang Shi, Xingxing Zang, Hao Wang, Christopher Nishimura, Xiaoxin Ren, Ulrich G. Steidl, Kira Gritsman, Murali Janakiram, Noah Kornblum, Olga Derman, Ioannis Mantzaris, Aditi Shastri, Rachel Bartash, Yoram Puius, Margaret McCort, Mendel Goldfinger, Lizamarie Bachier-Rodriguez, Amit Verma, Ira Braunschweig, R. Alejandro Sica
Meeting Abstract
Hematology
Angelica D'Aiello, Sumaira Zareef, Kith Pradhan, Amanda Lombardo, Fariha Khatun, Jennat Mustafa, Alyssa De Castro, Felisha Joseph, Kailyn Gillick, Anjali Naik, Astha Thakkar, Lauren C. Shapiro, Shafia Rahman, Zhu Cui, Jesus D. Gonzalez Lugo, Fiona Mienko, Numa Tarnima Rahman, Robert Lopez, Heidi Chwan Ko, Amanda Podolski, Vikas Mehta, Sanjay Goel, Rafi Kabarriti, Joseph Sparano, Stuart Packer, David Lawrence Fernandes, Enrico Castelucci, Margarita Kushnir, Mark Chaitowitz, Luca Paoluzzi, Ulrich G. Steidl, Phaedon Zavras, Ioannis Mantzaris, Noah Kornblum, Aditi Shastri, Lizamarie Bachier-Rodriguez, Kira Gritsman, Henny H. Billett, Rachel Bartash, Yoram Puius, Margaret Mccort, Ira Braunschweig, Mendel Goldfinger, Amit Verma, R. Alejandro Sica
Letter
Immunology
Victoria A. Muggia, Yoram A. Puius
EMERGING INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Jellyana Peraza, Yoram A. Puius
CURRENT FUNGAL INFECTION REPORTS
(2020)
