Article
Public, Environmental & Occupational Health
E. Baxter
Summary: Caesarean section is a common procedure with risk of surgical site infections. A programme led by a midwife successfully reduced the rate of CS SSI through targeted interventions. Hospitals should consider implementing surveillance and prevention programmes for CS SSI to achieve significant benefits with minimal resources.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Medicine, General & Internal
Rami Sommerstein, Nicolas Troillet, Stephan Harbarth, Marlieke E. A. de Kraker, Danielle Vuichard-Gysin, Stefan P. Kuster, Andreas F. Widmer
Summary: This study aimed to evaluate the relationship between the timing of administration of cefuroxime surgical antimicrobial prophylaxis (SAP) and the occurrence of surgical site infections (SSI). The results showed that cefuroxime SAP should be administered within 60 minutes prior to incision, and ideally within 10 to 25 minutes, to reduce the risk of SSI.
Article
Public, Environmental & Occupational Health
C. Bataille, A-G Venier, F. Caire, H. Salle, A. Le Guyader, F. Pesteil, R. Chauvet, P-S Marcheix, D. Valleix, L. Fourcade, K. Aubry, J. Brie, P-Y Robert, M. Pefau, M-C Ploy, N. D'Hollander-Pestourie, E. Couve-Deacon
Summary: The study described the evolution of trends in active SSI surveillance and implementation of prevention measures in a French Teaching Hospital over a 14-year period. The overall SSI rate decreased from 3.0% in 2003 to 1.1% in 2016, with reductions mainly seen in superficial SSIs and high infectious risk procedures. The findings highlighted the benefits of comprehensive hospital SSI surveillance and the importance of collaboration between surgeons and infection control practitioners.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Janneke D. M. Verberk, Stephanie M. van Rooden, David J. Hetem, Herman F. Wunderink, Anne L. M. Vlek, Corianne Meijer, Eva A. H. van Ravensbergen, Elisabeth G. W. Huijskens, Saara J. Vainio, Marc J. M. Bonten, Maaike S. M. van Mourik
Summary: This study investigated the reliability and validity of surgical site infection (SSI) surveillance after colorectal surgery in the Netherlands. The study found that raters were consistent in their SSI-ascertainment (good reliability), but improvements can be made regarding the accuracy (moderate validity). Accuracy of surveillance may be improved by providing regular training, adapting definitions to reduce subjectivity, and by supporting surveillance through automation.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Seven Johannes Sam Aghdassi, Hengameh Goodarzi, Alexander Gropmann, Joerg Clausmeyer, Christine Geffers, Brar Piening, Petra Gastmeier, Michael Behnke
Summary: Insights into the practices of German hospitals conducting surgical site infection surveillance and their IT infrastructures are limited. This study evaluated current surveillance practices, particularly the use of IT infrastructures, in German hospitals. The findings revealed significant variations in the adoption of digital solutions for surgical site infection surveillance among different surgical departments in Germany.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
S. J. S. Aghdassi, C. Schroder, P. Gastmeier
Summary: Urgent surgery increases the risk of SSIs for C-sections but not for colon surgeries. Collecting data on urgency is useful for SSI surveillance in C-sections but may be unnecessary for other procedures. Further research should focus on different types of procedures for SSI analysis.
JOURNAL OF HOSPITAL INFECTION
(2021)
Review
Public, Environmental & Occupational Health
Emmanuel Piednoir, Joan Robert-Yap, Patrice Baillet, Emilie Lermite, Niki Christou
Summary: Surgical site infections pose a significant economic burden, with costs varying depending on factors such as the patient and the type of surgery. Prevention of infections is a profitable concept for surgery and should be integrated into healthcare management globally.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Marcus Eder, Rami Sommerstein, Arlette Szelecsenyi, Alexander Schweiger, Matthias Schlegel, Andrew Atkinson, Stefan P. Kuster, Danielle Vuichard-Gysin, Nicolas Troillet, Andreas F. Widmer
Summary: A targeted intervention program aimed at optimizing preoperative management elements led to a statistically significant decrease in surgical site infection (SSI) cases, particularly in cardiac surgery. Additional prevention modules may be necessary for colon and orthopedic surgery.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2023)
Article
Public, Environmental & Occupational Health
A. G. M. L. Carvalho, D. C. Limaylla, T. N. Vilches, G. B. de Almeida, G. Madalosso, D. B. de Assis, C. M. C. B. Fortaleza
Summary: This study analyzed governmental surveillance data from 385 hospitals in inner Sao Paulo State, Brazil to assess spatial and sociodemographic predictors of surgical site infection (SSI) rates. The results showed that SSI rates were positively associated with distance from the state capital, and lower in non-profit and private facilities compared to public hospitals. Georeferencing results suggest the need to focus SSI-prevention policies on hospitals located farther from the state capital.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Ruth Royle, Brigid M. Gillespie, Wendy Chaboyer, Joshua Byrnes, Son Nghiem
Summary: This study aims to estimate the cost of surgical site infections in Australian public hospitals in 2018-19, highlighting the economic burden of hospital-associated infection. A cost-of-illness analysis was conducted based on literature data and simulation techniques. The study found that there were approximately 16,541 cases of surgical site infections in Australian public hospitals in 2018-19, with a total direct cost of A$323.5 million and an average cost per case of A$18,814.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Alvaro Flores-Balado, Carlos Castresana Mendez, Antonio Herrero Gonzalez, Raul Meson Gutierrez, Gonzalo de las Casas Camara, Beatriz Vila Cordero, Javier Arcos, Bernadette Pfang, Maria Dolores Martin-Rios
Summary: We present the design and validation of an algorithm for SSI detection after hip replacement surgery, which combines natural language processing (NLP) and extreme gradient boosting. The algorithm was successfully implemented in 4 public hospitals in Madrid, Spain, reducing surveillance time and improving accuracy.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Infectious Diseases
E. Patchen Dellinger, Diana Villaflor-Camagong, Estella Whimbey
Summary: By gradually introducing specific infection prevention methods and a surveillance system, the rate of surgical site infection was successfully reduced. In a complex medical environment like a tertiary referral center, preventing surgical site infections requires focused attention and collaboration from all healthcare professionals involved.
SURGICAL INFECTIONS
(2021)
Review
Surgery
Shalini Ahuja, Nathan Peiffer-Smadja, Kimberly Peven, Michelle White, Andrew J. M. Leather, Sanjeev Singh, Marc Mendelson, Alison Holmes, Gabriel Birgand, Nick Sevdalis
Summary: This study conducted a systematic scoping review of 21 studies on surgical site infection and antibiotic usage, finding that feedback plays a key role in reducing SSI rates and optimizing antibiotic usage. However, the optimal method, format, and frequency of feedback remain unclear and require further research and exploration.
Article
Infectious Diseases
Niloufar Taherpour, Yadollah Mehrabi, Arash Seifi, Babak Eshrati, Seyed Saeed Hashemi Nazari
Summary: This study investigated the epidemiologic characteristics of orthopedic SSIs and estimated the under-reporting of registries using the capture-recapture method. The results showed that a significant portion of orthopedic SSIs were not detected by the two sources among six hospitals, leading to a 63.32% under-reporting rate.
BMC INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Raymond J. Liou, Michelle J. Earley, Joseph D. Forrester
Summary: Surgical site infections (SSI) are common and costly hospital-acquired infections in the United States. This study found that meteorological variables such as temperature, humidity, and precipitation can affect the risk of SSI. The research also identified the Southeast region of the United States as being at the highest risk for climate change-related SSI.
SCIENTIFIC REPORTS
(2022)
Letter
Public, Environmental & Occupational Health
Sonali D. Advani, Michael E. Yarrington, Becky A. Smith, Deverick J. Anderson, Daniel J. Sexton
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Editorial Material
Immunology
Jessica Seidelman, Daniel J. Sexton
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Lona Mody, Ibukunoluwa C. Akinboyo, Hilary M. Babcock, Werner E. Bischoff, Vincent Chi-Chung Cheng, Kathleen Chiotos, Kimberly C. Claeys, K. C. Coffey, Daniel J. Diekema, Curtis J. Donskey, Katherine D. Ellingson, Heather M. Gilmartin, Shruti K. Gohil, Anthony D. Harris, Sara C. Keller, Eili Y. Klein, Sarah L. Krein, Jennie H. Kwon, Adam S. Lauring, Daniel J. Livorsi, Eric T. Lofgren, Katreena Merrill, Aaron M. Milstone, Elizabeth A. Monsees, Daniel J. Morgan, Luci P. Perri, Christopher D. Pfeiffer, Clare Rock, Sanjay Saint, Emily Sickbert-Bennett, Felicia Skelton, Katie J. Suda, Thomas R. Talbot, Valerie M. Vaughn, David J. Weber, Timothy L. Wiemken, Mohamed H. Yassin, Matthew J. Ziegler, Deverick J. Anderson
Summary: This white paper identifies knowledge gaps and challenges in healthcare epidemiology research related to COVID-19 and proposes a research agenda. It emphasizes the need for collaboration across disciplines and addresses issues related to nursing homes and social disparities.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Ibukunoluwa C. Akinboyo, Rebecca R. Young, Michael J. Smith, Sarah S. Lewis, Becky A. Smith, Deverick J. Anderson
Summary: Through prospective surveillance in community hospitals, 84 pediatric healthcare-associated infections were identified over a 6-year period. 61% of these infections were pediatric central-line-associated bloodstream infections, and they often occurred in children under 1 year of age.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Eric T. Lofgren, Matthew Mietchen, Kristen V. Dicks, Rebekah Moehring, Deverick Anderson
Summary: The study suggests that there is significant room for improvement in anti-MRSA disinfectants, including both the compounds themselves and their delivery mechanisms. Despite the decolonization estimates found in this study, these agents have robust outcomes even after delays in administration, which may help alleviate concerns over patient comfort and toxic effects.
Article
Medicine, General & Internal
Christina D. Mack, John DiFiori, Caroline G. Tai, Kristin Y. Shiue, Yonatan H. Grad, Deverick J. Anderson, David D. Ho, Leroy Sims, Christopher LeMay, Jimmie Mancell, Lisa L. Maragakis
Summary: In this retrospective cohort study of the 2020 NBA closed campus occupational health program, recovered individuals who continued to test positive for SARS-CoV-2 following discontinuation of isolation were not infectious to others. These findings support time-based US Centers of Disease Control and Prevention recommendations for ending isolation.
JAMA INTERNAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Robert Rolfe, Charles Kwobah, Florida Muro, Anushka Ruwanpathirana, Furaha Lyamuya, Champica Bodinayake, Ajith Nagahawatte, Bhagya Piyasiri, Tianchen Sheng, John Bollinger, Chi Zhang, Truls Ostbye, Shamim Ali, Richard Drew, Peter Kussin, Deverick J. Anderson, Christopher W. Woods, Melissa H. Watt, Blandina T. Mmbaga, L. Gayani Tillekeratne
Summary: This study identified important barriers to implementing ASPs in three tertiary care centers in LMICs, including improving drug availability, enhancing availability of and trust in microbiologic data, developing local guidelines, and providing education to physicians regarding antimicrobial prescribing.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Immunology
Jessica L. Seidelman, Nicholas A. Turner, Rebekah H. Wrenn, Christina Sarubbi, Deverick J. Anderson, Daniel J. Sexton, Rebekah W. Moehring
Summary: Weekly multidisciplinary antibiotic stewardship rounds in the intensive care units were associated with a small reduction in antibiotic use, with differential effects observed among specialty units. Customizing antibiotic stewardship rounds to match unit-specific population, workflow, and culture is important for maximizing effectiveness.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Nicholas A. Turner, Bobby G. Warren, Maria F. Gergen-Teague, Rachel M. Addison, Bechtler Addison, William A. Rutala, David J. Weber, Daniel J. Sexton, Deverick J. Anderson
Summary: Fidaxomicin and vancomycin are more effective in reducing C. difficile shedding and environmental contamination compared to metronidazole. Treatment choice may play a role in reducing healthcare-associated C. difficile transmission.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Sonali D. Advani, Becky A. Smith, Jessica Seidelman, Nicholas Turner, Deverick J. Anderson, Sarah S. Lewis
Summary: The paradoxical relationship between standardized infection ratio and standardized utilization ratio for CAUTIs compared to CLABSIs, along with challenges in CAUTI definition, incentivizes hospitals to prioritize prevention efforts on urine culture stewardship.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jessica L. Seidelman, Rebekah W. Moehring, David J. Weber, Deverick J. Anderson, Sarah S. Lewis
Summary: Patients who reported a penicillin or cephalosporin allergy had a higher risk of developing a surgical site infection (SSI) compared to non-allergic patients. However, the choice of surgical prophylaxis did not significantly affect this association. The reported allergy may serve as a surrogate marker for a more complex patient population.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sarah S. Lewis, Ibukunoluwa C. Kalu, Jessica Seidelman, Deverick J. Anderson, Rebekah W. Moehring, Becky A. Smith
Summary: The study found that without real-time adjudication, nearly 50% of HA-COVID-19 cases identified using electronic definitions were misclassified. Both electronic and traditional contact tracing methods likely underestimated the incidence of HA-COVID-19.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Diego Schaps, Andrew W. Godfrey, Deverick J. Anderson
Summary: This study found that patients who were transported to the emergency department by ambulance had a higher risk of developing MRSA or VRE within 30 days compared to those who arrived by private vehicle.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rebekah W. Moehring, Angelina Davis, Elizabeth Dodds Ashley, April P. Dyer, Richard H. Drew, Yuliya Loknyghina, Melissa D. Johnson, Travis M. Jones, S. Shaefer Spires, Daniel J. Sexton, Deverick J. Anderson
Summary: Policies promoting converting antibiotics from intravenous to oral administration are crucial for hospital antimicrobial stewardship programs, and developing metrics and comparison methods can help improve implementation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Review
Allergy
Bruce L. Zuraw, Marcus Maurer, Daniel J. Sexton, Marco Cicardi
Summary: Monoclonal antibodies (mAbs) have shown efficacy and safety in various therapeutic areas. This article discusses the advantages and limitations of mAbs compared to small molecules and introduces a novel mAb for the treatment of hereditary angioedema (HAE), a rare and life-threatening condition characterized by recurrent swelling attacks. Lanadelumab, a fully human mAb targeting plasma kallikrein, has demonstrated promising results in clinical trials, including a pivotal Phase 3 study. It has the potential to provide an effective and less burdensome treatment option for HAE patients.
ALLERGOLOGY INTERNATIONAL
(2023)