Article
Dentistry, Oral Surgery & Medicine
Arunima Mishra, Yuetan Dou, Charles Wang, Hansel M. Fletcher
Summary: This study found that Filifactor alocis can protect Porphyromonas gingivalis under oxidative stress conditions. The interaction between these two bacteria resulted in the modulation of several genes, including those involved in ABC transport and other cellular functions. These results suggest that F. alocis may stabilize the microbial community in the inflammatory microenvironment of the periodontal pocket by reducing oxidative stress.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Microbiology
Pruettichai Wisutep, Witchuda Kamolvit, Piriyaporn Chongtrakool, Anupop Jitmuang
Summary: This case report discusses a woman with a brain abscess in the left parietal lobe that presented as an atypical acute stroke-like syndrome. The pus samples from brain abscess aspiration revealed the presence of periodontal pathogens Porphyromonas gingivalis and Filifactor alocis. After receiving dental health care and 8 weeks of combined antimicrobial therapy, the patient made a full recovery.
Article
Dentistry, Oral Surgery & Medicine
Paul D. Veith, Dhana G. Gorasia, Eric C. Reynolds
Summary: This study aimed to establish a reliable list of outer membrane associated proteins for Porphyromonas gingivalis using bioinformatics tools to predict 151 proteins. The proteins were categorized into T9SS cargo proteins, lipoproteins, and OM beta-barrel proteins, each playing various roles in OM biogenesis, nutrient acquisition, protein secretion, adhesion, and efflux. Conservation scores within the Bacteroidales taxon were also noted to correlate with virulence factors, potentially indicating novel virulence factors.
MOLECULAR ORAL MICROBIOLOGY
(2021)
Review
Immunology
Shuxian Jia, Xiaobing Li, Qin Du
Summary: P. gingivalis is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. It expresses virulence factors that disrupt immunity and causes systemic diseases, including insulin resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Alex A. Knowles, Susan G. Campbell, Neil A. Cross, Prachi Stafford
Summary: This study investigated the molecular mechanisms by which P. gingivalis infection alters translation attenuation during oxidative stress-induced activation of the ISR in oral epithelial cells, using immunofluorescence confocal microscopy and immunoblotting. The findings revealed that infection coupled with stress caused differential stress granule formation and composition, and heightened stress-induced translational repression independently of core ISR mediators. The study also implicated the gingipain-mTOR axis as the effector of host translational dysregulation during stress.
Article
Dentistry, Oral Surgery & Medicine
Danielle Rodrigues de Andrade, Paulo Andre Silva, Ana Paula Colombo, Carina Maciel Silva-Boghossian
Summary: The study found that levels of specific periodontal health/disease-related oral bacteria were higher in OW and OB individuals compared to NW individuals, but without destructive periodontal disease. Additionally, some bacteria were associated with clinical parameters of obesity.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michal Smiga, John W. Smalley, Paulina Slezak, Jason L. Brown, Klaudia Sieminska, Rosalind E. Jenkins, Edwin A. Yates, Teresa Olczak
Summary: The study found that glycation increases the ability of Porphyromonas gingivalis to acquire heme from hemoglobin and promotes bacterial biofilm formation, thus enhancing its pathogenic potential in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yanjing Ou, Mingdong Yan, Guanglin Gao, Wenjie Wang, Qiaoqiao Lu, Jiang Chen
Summary: This study demonstrates the potential of orally administered cinnamaldehyde (CA) in controlling periodontitis by inhibiting bone resorption, anaerobic bacteria accumulation, and immunoinflammatory responses. CA also shows inhibitory effects on cytokine expression, cell senescence, and promotes osteogenic differentiation.
Review
Microbiology
Linah A. A. Shahoumi, Muhammad H. A. Saleh, Mohamed M. M. Meghil
Summary: Periodontitis, a common chronic oral disease in the US, causes destruction of tooth-supporting tissue and can lead to tooth loss. The interaction between periodontal bacteria and immune cells triggers a harmful immune response and tissue destruction. Certain pathogens, such as A. actinomycetemcomitans, P. gingivalis, and F. nucleatum, have been linked to periodontal disease formation and their virulence factors play a role in evading immune response and promoting carcinogenesis. This review examines how these pathogens modulate host cell signaling pathways and interfere with normal cell death.
Article
Entomology
Huanhuan Chen, Guangshuo Zhang, Guiling Ding, Jiaxing Huang, Hong Zhang, Mayra C. Vidal, Richard T. Corlett, Cong Liu, Jiandong An
Summary: The decline of bumblebees has raised concerns about ecosystem stability. Understanding the factors that shape bumblebees' pathogen community composition is important for predicting infectious diseases and conservation policies. The study found that host specificity was the most important variable in predicting pathogen occurrences and community composition in bumblebees.
Article
Cell Biology
Carolina Duarte, Chiaki Yamada, Christopher Garcia, Juliet Akkaoui, Anny Ho, Frank Nichols, Alexandru Movila
Summary: Emerging studies suggest that non-eukaryotic ceramide, specifically PGDHC produced by Porphyromonas gingivalis, can promote RANKL-mediated osteoclastogenesis through direct activation of intracellular CatB.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Josefa Nunez-Belmar, Mauricio Morales-Olavarria, Emiliano Vicencio, Rolando Vernal, Juan P. Cardenas, Cristian Cortez
Summary: This review discusses the use of different -omics technologies and techniques in studying the pathogenic potential of P. gingivalis and its interaction with the host.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
A. Wielento, K. B. Lagosz-Cwik, J. Potempa, A. M. Grabiec
Summary: Gingival fibroblasts (GFs) play an essential role in maintaining the structure and integrity of the periodontium. They not only produce and remodel the extracellular matrix but also modulate the immune response to oral pathogens invading the gingival tissue. However, dysregulated activation of GFs can lead to inflammation and bone destruction, particularly in chronic periodontitis. This review discusses the biological functions of GFs in healthy and inflamed gingival tissue and explores their potential as therapeutic targets in periodontal diseases.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Microbiology
Muhammad Kashif, Jaana Jurvansuu, Rafiqul Hyder, Eeva J. Vainio, Jarkko Hantula
Summary: The study revealed that the genome sequences of the fast-growing sector strain 94233-RC3 infected by the virus HetPV13-an1 were similar to the original slowly growing strain 94233, but displayed different gene expression during transcription. Some genes were downregulated while others were upregulated, indicating the impact of the virus on the host transcriptome, although not causing significant effects.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Fernanda G. Rocha, Gregory Ottenberg, Zavier G. Eure, Mary E. Davey, Frank C. Gibson
Summary: The study reveals that P. gingivalis delivers sphingolipids to host cells via OMVs, which can limit host inflammatory response. A mutant lacking sphingolipids induces a stronger inflammatory immune response compared to the wild-type strain.
INFECTION AND IMMUNITY
(2021)
Correction
Multidisciplinary Sciences
Arun S. Muthiah, Wilson Aruni, Antonette G. Robles, Yuetan Dou, Francis Roy, Hansel M. Fletcher
Article
Biochemistry & Molecular Biology
Zhenjiang Li, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Srinivasa Rao Bolla, Hariprasath Lakshmanan, Subramanian Kumaran, Wilson Aruni, Aref Ali Mohammed Aladresi, Omar H. M. Shair, Sulaiman Ali Alharbi, Arunachalam Chinnathambi
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Senthil Rethinam, Sumathi Vijayan, A. Wilson Aruni, Bahri Basaran, Tamilselvi Alagumuthu, Rajalakshmi Ramamoorthy
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Pandiyan Muthuramalingam, Rajendran Jeyasri, Anthonymuthu Selvaraj, Dhamodharan Kalaiyarasi, Wilson Aruni, Shunmugiah Thevar Karutha Pandian, Manikandan Ramesh
Summary: In this study, the global transcriptome analysis of the OsSAP gene family revealed their crucial role in plant response to biotic and abiotic stresses. Computational expression signature provided insights into the dynamic characteristics of these genes in diverse developmental tissues/organs. Transcriptional regulation analysis highlighted the novel roles of key OsSAP genes in response to stress.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biotechnology & Applied Microbiology
Selvaraj Alagu Lakshmi, James Prabhanand Bhaskar, Venkateswaran Krishnan, Sivasamy Sethupathy, Selvapandi Pandipriya, Wilson Aruni, Shunmugiah Karutha Pandian
JOURNAL OF BIOTECHNOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Senthil Rethinam, Bahri Basaran, Sumathi Vijayan, Ali Mert, Oguz Bayraktar, A. Wilson Aruni
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Article
Multidisciplinary Sciences
Kumaran Subramanian, Balamurugan Sadaiappan, Wilson Aruni, Alagappan Kumarappan, Rajasekar Thirunavukarasu, Guru Prasad Srinivasan, Selvaraj Bharathi, Prasannabalaji Nainangu, Pugazhvendan Sampath Renuga, Anandajothi Elamaran, Deivasigamani Balaraman, Mahendran Subramanian
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Subramani Prabha, Jothipandiyan Sowndarya, Parepalli Janaki Venkata Sai Ram, Durairajan Rubini, B. Narayanan Vedha Hari, Wilson Aruni, Paramasivam Nithyanand
Summary: The study demonstrated that chitosan extracted from crab shells could effectively prevent the colonization of bacterial and fungal pathogens at surgical sites, showing better performance compared to commercial chitosan. The chitosan-coated sutures not only inhibited the growth of bacteria and fungi, but also prevented hyphal formation, reducing invasiveness.
CURRENT MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Panneerselvam Saravanan, Subramanian Kumaran, Selvaraj Bharathi, Padmanaban Sivakumar, Padian Sivakumar, Sampath Renuga Pugazhvendan, Wilson Aruni, Sahadevan Renganathan
Summary: This study found that the yeast Pichia pastoris could accumulate both Reactive Red 11 (RR11) and Acid Green 1 (AG1) dyes, with optimal performance at pH 2. As the dye concentration increased, the color removal efficiency, specific growth rate, and dried biomass concentration decreased, while the dye uptake capacity increased.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2021)
Article
Biotechnology & Applied Microbiology
Senthil Rethinam, Tamilselvi Alagumuthu, Kumaran Subaramaniyan, A. Wilson Aruni, Serdar Batikan Kavukcu
Summary: The combination of collagen, gelatin, and squid ink produced a bio-scaffold examined for wound healing. The scaffold displayed good mechanical properties, antimicrobial characteristics, and accelerated wound healing in in vivo studies on mice.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tentu Nageswara Rao, A. P. B. Balaji, Mani Panagal, Botsa Parvatamma, Bharathi Selvaraj, Saravanan Panneerselvam, Wilson Aruni, Kumaran Subramanian, Pugazhvendan Sampath Renuga, Sivakumar Pandian
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2020)
Article
Biotechnology & Applied Microbiology
Mary Shamya Arokia rajan, Rajasekar Thriunavukkarasu, Jerrine Joseph, Wilson Aruni
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Subramanian Kumaran, Selvaraj Bharathi, Vairagkar Uttra, Rajasekar Thirunavukkarasu, Prasannabalaji Nainangu, Venugopal Gopi Krishnan, Pugazhvendan Sampath Renuga, Aruni Wilson, Deivasigamani Balaraman
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2020)
Article
Genetics & Heredity
Lakshmi Krishnasamy, Durairajan Rubini, Jayasankari Senthilganesh, Chitralekha Saikumar, Govindasamy Kumaramanickavel, A. Wilson Aruni, Paramasivam Nithyanand
Review
Microbiology
Preethi Sudhakara, Iyappan Sellamuthu, A. Wilson Aruni