Journal
INFECTION AND IMMUNITY
Volume 82, Issue 4, Pages 1692-1697Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01508-13
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Funding
- Public Health Service [AI044170, AI076246, AI096528]
- NIH [RR12088]
- Public Health Services [OD11147]
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Gamma interferon (IFN-gamma) is an important driver of intestinal inflammation during colitis caused by Salmonella enterica serovar Typhimurium. Here we used the mouse colitis model to investigate the cellular sources of IFN-gamma in the cecal mucosa during the acute phase of an S. Typhimurium infection. While IFN-gamma staining was detected in T cells, NK cells, and inflammatory monocytes at 2 days after infection, the majority of IFN-gamma-positive cells in the cecal mucosa were neutrophils. Furthermore, neutrophil depletion blunted mucosal Ifng expression and reduced the severity of intestinal lesions during S. Typhimurium infection. We conclude that neutrophils are a prominent cellular source of IFN-gamma during the innate phase of S. Typhimurium-induced colitis.
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