Review
Biochemistry & Molecular Biology
Stephan Kohler, Safia Ouahrani-Bettache, Jean-Yves Winum
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2017)
Article
Immunology
Elias Abdou, Maria P. Jimenez de Bagues, Ignacio Martinez-Abadia, Safia Ouahrani-Bettache, Veronique Pantesco, Alessandra Occhialini, Sascha Al Dahouk, Stephan Kohler, Veronique Jubier-Maurin
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Immunology
Maykel A. Arias, Llipsy Santiago, Santiago Costas-Ramon, Paula Jaime-Sanchez, Marina Freudenberg, Maria P. Jimenez De Bagues, Julian Pardo
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Microbiology
Luca Freddi, Maria A. Damiano, Laurent Chaloin, Eugenia Pennacchietti, Sascha Al Dahouk, Stephan Kohler, Daniela De Biase, Alessandra Occhialini
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Microbiology
Carlos Calvete, Manuel Mendoza, Ana Alcaraz, Maria P. Sarto, Maria P. Jimenez-de-Baguess, Antonio J. Calvo, Fernando Monroy, Jorge H. Calvo
VETERINARY MICROBIOLOGY
(2018)
Article
Veterinary Sciences
Carlos Calvete, Manuel Mendoza, Maria P. Sarto, Maria P. Jimenez de Bagues, Lluis Lujan, Jessica Mollin, Antonio J. Calvo, Fernando Monroy, Jorge H. Calvo
JOURNAL OF WILDLIFE DISEASES
(2019)
Article
Multidisciplinary Sciences
Sascha Al Dahouk, Stephan Koehler, Alessandra Occhialini, Maria Pilar Jimenez de Bagues, Jens Andre Hammerl, Tobias Eisenberg, Gilles Vergnaud, Axel Cloeckaert, Michel S. Zygmunt, Adrian M. Whatmore, Falk Melzer, Kevin P. Drees, Jeffrey T. Foster, Alice R. Wattam, Holger C. Scholz
SCIENTIFIC REPORTS
(2017)
Article
Microbiology
Anett K. Larsen, Ingebjorg H. Nymo, Karen K. Sorensen, Marit Seppola, Rolf Rodven, Maria Piler Jimenez de Bagues, Sascha Al Dahouk, Jacques Godfroid
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Microbiology
Jorge A. de la Garza-Garcia, Safia Ouahrani-Bettache, Sebastien Lyonnais, Erika Ornelas-Eusebio, Luca Freddi, Sascha Al Dahouk, Alessandra Occhialini, Stephan Koehler
Summary: Our study focused on identifying and characterizing acid resistance determinants of B. suis and B. microti at different pH levels, revealing species-specific mechanisms in response to acid stress. The results showed that B. microti has rapid physiological adaptation to acid stress with specific differential gene expression, while B. suis response indicated increased protein misfolding under acid stress. The findings support the hypothesis that the enhanced acid stress resistance of B. microti is due to selective pressure for critical gene functionality and specific differential gene expression, leading to rapid adaptation.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Microbiology
Alessandra Occhialini, Dirk Hofreuter, Christoph-Martin Ufermann, Sascha Al Dahouk, Stephan Kohler
Summary: The genus Brucella consists of twelve species of intracellular bacteria with varying zoonotic potential. While six of them are considered classical and known to cause brucellosis in terrestrial mammals, the remaining two species originate from marine mammals. Recent research has led to the discovery of four new species, as well as numerous strains isolated from a wide range of hosts, including cold-blooded animals. These newly identified species exhibit atypical phenotypes, such as higher growth rate, increased resistance to acid stress, motility, and lethality in murine infection models. This review provides an overview of the latest knowledge on these novel Brucella species, highlighting their phylogenetic positions, metabolic characteristics, acid stress resistance mechanisms, and behavior in well-established infection models. The comparison between classical and novel Brucella species and strains leads to a proposed more adapted terminology, distinguishing between core and non-core, and typical versus atypical brucellae.
Article
Microbiology
Luca Freddi, Jorge A. de la Garza-garcia, Sascha Al Dahouk, Alessandra Occhialini, Stephan Koehler
Summary: This study reveals that atypical Brucella species can grow under anoxic conditions strictly dependent on nitrate, while classical species exhibit different behavior. Atypical Brucella species have a more efficient denitrification pathway and rapid consumption of nitrite, which may be related to their ability to colonize different hosts and rapid growth.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Safia Ouahrani-Bettache, Maria P. Jimenez De Bagues, Jorge De La Garza, Luca Freddi, Juan P. Bueso, Sebastien Lyonnais, Sascha Al Dahouk, Daniela De Biase, Stephan Kohler, Alessandra Occhialini