Multilaboratory Approach to Preclinical Evaluation of Vaccine Immunogens for Placental Malaria

High Levels of Antibodies to Multiple Domains and Strains of VAR2CSA Correlate with the Absence of Placental Malaria in Cameroonian Women Living in an Area of High Plasmodium falciparum Transmission

(2012) Yeung L. Tutterrow et al.   INFECTION AND IMMUNITY

The NTS-DBL2X Region of VAR2CSA Induces Cross-Reactive Antibodies That Inhibit Adhesion of Several Plasmodium falciparum Isolates to Chondroitin Sulfate A

(2011) Pascal Bigey et al.   JOURNAL OF INFECTIOUS DISEASES

Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins

(2011) Marion Avril et al.   MALARIA JOURNAL

Pregnancy malaria: cryptic disease, apparent solution

(2011) Patrick Emmet Duffy et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA

(2011) Vera V. Pinto et al.   PLoS One

Antibodies to a Full-Length VAR2CSA Immunogen Are Broadly Strain-Transcendent but Do Not Cross-Inhibit Different Placental-Type Parasite Isolates

(2011) Marion Avril et al.   PLoS One

Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes

(2010) M. Avril et al.   INFECTION AND IMMUNITY

Full-Length Recombinant Plasmodium falciparum VAR2CSA Binds Specifically to CSPG and Induces Potent Parasite Adhesion-Blocking Antibodies

(2010) Pongsak Khunrae et al.   JOURNAL OF MOLECULAR BIOLOGY

Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies

(2010) Ali Salanti et al.   MALARIA JOURNAL

Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate

(2010) Stéphane Gangnard et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Strain-Transcendent Immune Response to Recombinant Var2CSA DBL5-ε Domain Block P. falciparum Adhesion to Placenta-Derived BeWo Cells under Flow Conditions

(2010) Pablo Fernandez et al.   PLoS One

Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?

(2010) Madeleine Dahlbäck et al.   TRENDS IN PARASITOLOGY

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

(2010) Pamela A. Magistrado et al.   VACCINE

Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA

(2009) M. A. Nielsen et al.   INFECTION AND IMMUNITY

Structural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during Pregnancy

(2009) Pongsak Khunrae et al.   JOURNAL OF MOLECULAR BIOLOGY

Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris

(2009) Marion Avril et al.   MALARIA JOURNAL

Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA

(2008) M. Avril et al.   INFECTION AND IMMUNITY

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected Erythrocytes

(2008) Pamela Magistrado et al.   JOURNAL OF INFECTIOUS DISEASES

VAR2CSA Domains Expressed inEscherichia coliInduce Cross‐Reactive Antibodies to Native Protein

(2008) Andrew V. Oleinikov et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA

(2008) Mafalda Resende et al.   MALARIA JOURNAL

Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites

(2008) Pablo Fernandez et al.   MALARIA JOURNAL