Article
Dentistry, Oral Surgery & Medicine
Daniele Peron, Renato Araujo Prates, Ednei Luiz Antonio, Ighor Luiz Azevedo Teixeira, Helenita Antonia de Oliveira, Barbara Sampaio Dias Martins Mansano, Alexandre Bergamo, Dirceu Rodrigues Almeida, Rafael Dariolli, Paulo Jose Ferreira Tucci, Andrey Jorge Serra
Summary: This study demonstrates that inoculation of Porphyromonas gingivalis may lead to cardiac remodeling and dysfunction in rats, suggesting a potential role of this bacterium in the pathogenesis of heart failure.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Erika B. Danella, Marcell Costa de Medeiros, Nisha J. D'Silva
Summary: The oral mucosa plays a crucial role in protecting against physical, microbial, and chemical damage. When compromised, the wound healing response is activated, which involves processes such as immune infiltration, re-epithelialization, and stroma remodeling, all controlled by cytokines that promote cellular migration, invasion, and proliferation. These same cytokines are also implicated in cancer dissemination. Therefore, studying the cytokines involved in oral wound healing can provide insights into the cytokines exploited by oral squamous cell carcinoma (SCC) to promote tumor development and progression.
Article
Biochemistry & Molecular Biology
Patricia Milagros Maquera-Huacho, Denise Palomari Spolidorio, John Manthey, Daniel Grenier
Summary: This study evaluated the effect of hesperidin on periodontal tissues infected with Porphyromonas gingivalis. The results showed that hesperidin protected the epithelial barrier function, reduced bacterial adherence, inhibited ROS production, and attenuated the inflammatory response. These findings indicate that hesperidin has potential therapeutic properties for periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Cole B. Matrishin, Elaine M. Haase, Floyd E. Dewhirst, Jessica Mark L. Welch, Fabiola Miranda-Sanchez, Tsute Chen, Donald C. MacFarland, Kathryn M. Kauffman
Summary: This study reveals that phages play a significant role in shaping the ecology and strain-level diversity of Pg, providing new insights into the understanding of periodontal disease.
Article
Immunology
Ni Kang, Yong Zhang, Fei Xue, Jinyu Duan, Fan Chen, Yu Cai, Qingxian Luan
Summary: This study found that oral administration of Porphyromonas gingivalis can induce periodontitis and affect the occurrence and development of diabetes. The expression levels of inflammatory cytokines and chemokines changed in the gingiva and blood, leading to alveolar bone loss and inflammatory changes in the liver and adipose tissues. The study also showed a promotion of glucose metabolism disorder in mice.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Hassan Valadbeigi, Saeed Khoshnood, Babak Negahdari, Abbas Maleki, Medya Mohammadinejat, Mohammad Hossein Haddadi
Summary: This review discusses the role of F. nucleatum in the formation of mixed oral biofilms and its antibiotic resistance. The study highlights the clinical relevance of targeted interactions of F. nucleatum in oral biofilms.
Article
Multidisciplinary Sciences
Gina R. Lewin, Kendall S. Stocke, Richard J. Lamont, Marvin Whiteley
Summary: This study characterizes the behavior and virulence of the periodontal pathogen Porphyromonas gingivalis during human infection. It reveals that P. gingivalis is highly expressed in diseased samples, with genes related to virulence factors and growth/matabolism being actively expressed. The study also shows that the gene expression of P. gingivalis during periodontitis is highly conserved with logarithmic laboratory growth, suggesting that simple test tube growth can be used as a model for studying P. gingivalis biology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Dentistry, Oral Surgery & Medicine
A. Wielento, K. B. Lagosz-Cwik, J. Potempa, A. M. Grabiec
Summary: Gingival fibroblasts (GFs) play an essential role in maintaining the structure and integrity of the periodontium. They not only produce and remodel the extracellular matrix but also modulate the immune response to oral pathogens invading the gingival tissue. However, dysregulated activation of GFs can lead to inflammation and bone destruction, particularly in chronic periodontitis. This review discusses the biological functions of GFs in healthy and inflamed gingival tissue and explores their potential as therapeutic targets in periodontal diseases.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Microbiology
Izabela Ciaston, Joanna Budziaszek, Dorota Satala, Barbara Potempa, Andrew Fuchs, Maria Rapala-Kozik, Danuta Mizgalska, Ewelina Dobosz, Richard J. Lamont, Jan Potempa, Joanna Koziel
Summary: The study found that inactive gingipains still elicit a strong inflammatory response in gingival tissues, which may contribute to the progression of periodontitis and bone resorption. Moreover, host molecules were identified as receptors for proteolytically inactivated gingipains. The broad distribution of these receptors in human tissues suggests their involvement in systemic diseases associated with periodontal pathogens.
Review
Immunology
Sen Kang, Anna Dai, Huiming Wang, Pei-Hui Ding
Summary: This article discusses the interaction between autophagy and inflammation caused by Porphyromonas gingivalis infection, aiming to elaborate on the possible mechanism involved in the interaction.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Shuhui Zhou, Yaoting Ji, Hantao Yao, Haiying Guo, Zichen Zhang, Zijun Wang, Minquan Du
Summary: This study found that ginsenoside Rd has inhibitory effects on periodontitis-related bacteria and inflammatory response, as well as the ability to inhibit bone resorption induced by periodontitis. The results provide potential evidence for the development of Rd as a medication for the control and prevention of periodontitis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Cheng-Hsiang Kuo, Ban-Hua Zhang, Shang-En Huang, Jong-Hau Hsu, Yan-Hsiung Wang, Thi Tuyet Ngan Nguyen, Chao-Han Lai, Jwu-Lai Yeh
Summary: This study demonstrates the therapeutic potential of KMUP-1 in the treatment of periodontitis. KMUP-1 attenuates inflammation and osteoclast differentiation, thus reducing the symptoms of periodontitis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuko Teraoka, Jun Sugimoto, Haruhisa Konishi, Hiroshi Miyoshi, Hisako Furusho, Mutsumi Miyauchi, Shunichi Kajioka, Iemasa Koh, Yoshiki Kudo
Summary: This study investigated the effects of progesterone (P4) on uterine contractility and inflammation of the fetal membrane in a mouse model of chronic inflammation caused by Porphyromonas gingivalis (P.g.) infection. The results showed that P4 prolonged the gestation period, suppressed uterine contractility, and reduced inflammatory cytokine expression, suggesting its potential in preventing preterm birth.
Article
Cell Biology
Junhong Xiao, Xin Huang, Huiyi Wang, Yan Peng, Heyu Liu, Hantao Huang, Li Ma, Chuan Wang, Xiaoxuan Wang, Zhengguo Cao
Summary: In this study, the levels of CKIP-1 expression and autophagy were shown to increase in periodontal tissues. The knockout of CKIP-1 was found to activate autophagy, and activating autophagy was shown to reduce inflammation in periodontal tissues. These findings demonstrate the important role of CKIP-1 in regulating periodontal tissue inflammation.
Article
Oncology
Manila Hada, Matthew L. Edin, Patricia Hartge, Fred B. Lih, Nicolas Wentzensen, Darryl C. Zeldin, Britton Trabert
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2019)
Letter
Allergy
Emily C. McGowan, Roger Peng, Paivi M. Salo, Darryl C. Zeldin, Corinne A. Keet
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2019)
Article
Allergy
Lara J. Akinbami, Paivi M. Salo, Michelle M. Cloutier, Jesse C. Wilkerson, Kurtis S. Elward, Jacek M. Mazurek, Sonja Williams, Darryl C. Zeldin
Article
Cardiac & Cardiovascular Systems
Nicholas S. Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah Mazi, Matthew L. Edin, Mark Geoffrey Chambers, Marina Korotkova, Xiaomeng Wang, Walter Wahli, Darryl C. Zeldin, Rolf Nusing, Yingbi Zhou, Per-Johan Jakobsson, Jane A. Mitchell
CARDIOVASCULAR RESEARCH
(2020)
Article
Environmental Sciences
Angelico Mendy, Paivi M. Salo, Jesse Wilkerson, Lydia Feinstein, Kelly K. Ferguson, Michael B. Fessler, Peter S. Thorne, Darryl C. Zeldin
ENVIRONMENTAL RESEARCH
(2020)
Article
Immunology
Shepherd H. Schurman, Terrance P. O'Hanlon, John A. McGrath, Artiom Gruzdev, Arsun Bektas, Hong Xu, Stavros Garantziotis, Darryl C. Zeldin, Frederick W. Miller
JOURNAL OF AUTOIMMUNITY
(2020)
Article
Public, Environmental & Occupational Health
Lydia Feinstein, Jesse Wilkerson, Paivi M. Salo, Nathaniel MacNell, Matthew F. Bridge, Michael B. Fessler, Peter S. Thorne, Angelico Mendy, Richard D. Cohn, Matthew D. Curry, Darryl C. Zeldin
Article
Cell Biology
Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Mohammed A. Nayeem
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Stephanie Agba, Ahmad Hanif, Matthew L. Edin, Darryl C. Zeldin, Mohammed A. Nayeem
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Environmental Sciences
Angelico Mendy, Jesse Wilkerson, Paivi M. Salo, Darryl C. Zeldin, Peter S. Thorne
ENVIRONMENTAL HEALTH
(2020)
Article
Rheumatology
Gregg E. Dinse, Christine G. Parks, Clarice R. Weinberg, Caroll A. Co, Jesse Wilkerson, Darryl C. Zeldin, Edward K. L. Chan, Frederick W. Miller
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Theresa Aliwarga, Xiaoyun Guo, Eric A. Evangelista, Rozenn N. Lemaitre, Nona Sotoodehnia, Sina A. Gharib, Darryl C. Zeldin, Qinghang Liu, Rheem A. Totah
Article
Biochemistry & Molecular Biology
Haley Overby, Yang Yang, Xinyun Xu, Katherine Graham, Kelsey Hildreth, Sue Choi, Debin Wan, Christophe Morisseau, Darryl C. Zeldin, Bruce D. Hammock, Shu Wang, Ahmed Bettaieb, Ling Zhao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Respiratory System
Paivi M. Salo, Angelico Mendy, Jesse Wilkerson, Samantha A. Molsberry, Lydia Feinstein, Stephanie J. London, Michael B. Fessler, Peter S. Thorne, Darryl C. Zeldin
Summary: In this study, lower serum levels of vitamins A, C, D, and E were found to be associated with increased respiratory morbidity and/or mortality in the U.S. adult population. These results underscore the importance of antioxidant vitamins in respiratory health.
RESPIRATORY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Matthew L. Edin, Haruto Yamanashi, William E. Boeglin, Joan P. Graves, Laura M. DeGraff, Fred B. Lih, Darryl C. Zeldin, Alan R. Brash
Summary: The mammalian epoxide hydrolase (EPHX)3 is responsible for hydrolyzing epoxyalcohol derived triols in the 12R-lipoxygenase pathway and plays a crucial role in maintaining skin barrier integrity. This enzyme is essential for controlling metabolism flux through the alternative pathway and contributes to the transformation of naturally esterified epoxide substrates in other tissues.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)