Article
Biochemistry & Molecular Biology
Audrey Inge Schytz Andersen-Civil, Laura J. Myhill, Nilay Budeyri Gokgoz, Marica T. Engstrom, Helena Mejer, Ling Zhu, Wayne E. Zeller, Juha-Pekka Salminen, Lukasz Krych, Charlotte Lauridsen, Dennis S. Nielsen, Stig M. Thamsborg, Andrew R. Williams
Summary: Dietary proanthocyanidins (PAC) have limited activity to modulate naturally-induced type-2 pulmonary inflammation but significantly enhance immune function and antioxidant responses in the gut. PAC consumption can also affect gut microbiota composition and increase the abundance of Limosilactobacillus reuteri. This research sheds light on the health-promoting properties of PAC-rich foods and their potential as dietary supplements to regulate mucosal inflammatory responses in the gastrointestinal tract.
Article
Gastroenterology & Hepatology
Yougen Zhan, Stephen C. Ward, Maria Isabel Fiel, Julie Teruya-Feldstein, Eileen M. McKay, Fumiko Dekio
Summary: The study found disrupted apical-basal polarity of cholangiocytes and ductopenia in patients with Tufting enteropathy (TE). EpCam was shown to play a role in maintaining the integrity of biliary epithelium, and there was evidence of disrupted development of hepatic reparative cells in TE patients.
LIVER INTERNATIONAL
(2021)
Article
Parasitology
M. J. Evans, Y. Corripio-Miyar, A. Hayward, F. Kenyon, T. N. McNeilly, D. H. Nussey
Summary: Gastrointestinal nematodes have significant impacts on sheep production and their interactions can affect the epidemiology and clinical impacts of infection. This study found strong evidence for antagonistic interactions between co-infecting GIN species in sheep, with the presence of one species leading to a decrease in the number of worms of the other species. The extent of these interactions varied between parasite species and was dependent on the infectious dose. These findings highlight the importance of studying GIN co-infections for epidemiological and clinical research.
VETERINARY PARASITOLOGY
(2023)
Article
Cell Biology
Carlos Camacho-Macorra, Marcos Sintes, Noemi Tabanera, Irene Grasa, Paola Bovolenta, Marcos J. Cardozo
Summary: Hedgehog (Hh) signaling pathway is highly regulated and mutations in its components can lead to a variety of congenital malformations. Mosmo, a modulator of the Hh pathway, plays a role in down-modulating pathway activation. Studies in zebrafish embryos suggest that MOSMO may be a candidate gene for uncharacterized forms of human congenital craniofacial malformations.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Parasitology
J. A. N. Filipe, I. Kyriazakis, C. McFarland, E. R. Morgan
Summary: Gastrointestinal nematode (GIN) infections in livestock are common and have negative effects on health and performance. Due to anthelmintic resistance and climate change, alternative approaches to treatment and management are needed. In this study, a new epidemiological model of GIN transmission in a herd of grazing cattle was developed, taking into account host tolerance, parasite burden, immunity, weather-dependent development of parasites, and grass availability. The model showed satisfactory performance and has the potential to explore altered infection dynamics and optimize treatment strategies.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2023)
Article
Ecology
Ellis Wiersma, Robin J. Pakeman, Xavier Bal, Jill G. Pilkington, Josephine M. Pemberton, Daniel H. Nussey, Amy R. Sweeny
Summary: Recent studies have shown that fine scale spatial variation is important in the infection dynamics of gastrointestinal nematode parasites in wildlife systems. This study used data from over two decades of Soay sheep to examine the relationship between parasite burden and spatial autocorrelation and vegetation. The results showed that the effects of vegetation and space on parasite burden vary across different age groups.
JOURNAL OF ANIMAL ECOLOGY
(2023)
Article
Microbiology
Manon Loubens, Carine Marinach, Clara-Eva Paquereau, Soumia Hamada, Benedicte Hoareau-Coudert, David Akbar, Jean-Francois Franetich, Olivier Silvie
Summary: The authors characterized a protein called CLAMP, which was found to play an essential role in invasive stages of the malaria parasite and could be a potential target for transmission-blocking antimalarial strategies.
Article
Oncology
Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Summary: Through the Cryab overexpression knock-in mouse model, it was found that CRYAB overexpression led to the formation of various lethal tumors, correlated with upregulation of epithelial-to-mesenchymal transition markers, angiogenesis, and some oncogenic proteins. Further experiments showed that CRYAB overexpression promoted cell survival by upregulating Akt signaling and downregulating JNK-mediated pro-apoptotic pathway, inhibiting apoptosis.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jovana R. Gotovac, Tanjina Kader, Julia Milne, Kenji M. Fujihara, Luis E. Lara-Gonzalez, Kylie L. Gorringe, Sangeetha N. Kalimuthu, Madawa W. Jayawardana, Cuong P. Duong, Wayne A. Phillips, Nicholas J. Clemons
Summary: The study explores the impact of SMAD4 loss on TGF-beta signaling and tumorigenicity in high-grade dysplastic Barrett's cells. SMAD4 knockout alters the expression of TGF-beta target genes, upregulating potential oncogenes and downregulating tumor-suppressor genes. Inactivation of SMAD4 promotes tumorigenesis and genomic instability, suggesting that SMAD4 plays a critical role in EAC development and progression.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Parasitology
Seila Couso-Perez, Elvira Ares-Mazas, Hipolito Gomez-Couso
Summary: The study found that trout in rivers in Galicia, Spain, were parasitized by various species of helminths. Additionally, changes in water quality may affect the composition of helminths.
PARASITOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Lama Awwad, Tomer Goldenberg, Irina Langier-Goncalves, Ami Aronheim
Summary: Cardiovascular diseases and cancer are the leading causes of death worldwide, and they have a high co-prevalence and mutual influence. Recent studies suggest that heart failure may promote cancer progression, but whether cardiac remodeling without cardiac contractile dysfunction can promote cancer progression remains uncertain. In this study, using a mouse model, it was found that low-dose PE infusion can promote tumor growth and is associated with abundant secretion of cardiac and tumor factors. Therefore, early detection and treatment of hypertension may benefit the prognosis of cancer patients.
Article
Genetics & Heredity
Yijie Zhao, Binbin Jin, Peiwen Liu, Xiaolin Xiao, Lijun Cai, Zhensheng Xie, Ling Kong, Tong Liu, Wenqiang Yang, Yang Wu, Jinbao Gu, Zhijian Tu, Anthony A. James, Xiao-Guang Chen
Summary: This study found that AalNix is the primary signal for male sex determination in Aedes albopictus and can convert females into phenotypically masculinized pseudo-males while still retaining their fertility and flight capability.
Article
Biochemistry & Molecular Biology
Laura M. Bond, Ayon Ibrahim, Zon W. Lai, Rosemary L. Walzem, Roderick T. Bronson, Olga R. Ilkayeva, Tobias C. Walther, Robert Farese Jr
Summary: The ER-resident protein FIT2 plays a crucial role in acyl-CoA cleavage and is necessary for ER homeostasis and lipid storage. In hepatocyte-specific Fitm2 knockout mice, elevated acyl-CoA levels, ER stress, and liver injury were observed. These mice also had impaired triglyceride secretion and reduced fatty acid oxidation. Surprisingly, a high-fat diet worsened ER stress and liver injury but reversed the steatosis phenotype. These findings highlight the importance of FIT2 in liver function and ER homeostasis in mice.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Jean-Marie Jacob, Selene E. Di Carlo, Igor Stzepourginski, Anthony Lepelletier, Papa Diogop Ndiaye, Hugo Varet, Rachel Legendre, Etienne Kornobis, Adam Benabid, Giulia Nigro, Lucie Peduto
Summary: The transcriptomic switch induced by PDGFR alpha in intestinal stromal cells is crucial for coordinating postnatal intestinal maturation and function.
Review
Gastroenterology & Hepatology
Gerald J. Holtmann, Alexander Huelsen, Ayesha Shah, Luke F. Hourigan, Mark Morrison
Summary: Gastrointestinal endoscopy has greatly advanced with the development of fiberoptic instruments and optical chips, but still faces challenges such as operator-dependent diagnostics, the need for sedation, difficulties in cleaning reusable endoscopes, and the risk of infection transmission. Innovative technologies such as artificial intelligence and single-use designs have the potential to address these challenges, but their implementation would require a paradigm shift in the industry.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Immunology
Junhua Wang, Christine Goepfert, Norbert Mueller, Alessandra Piersigilli, Renyong Lin, Hao Wen, Dominique A. Vuitton, Lucine Vuitton, Christoph Mueller, Bruno Gottstein
Article
Biochemistry & Molecular Biology
Bahtiyar Yilmaz, Pascal Juillerat, Ove Oyas, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Karim Abdelrahman, Gentiana Ademi, Patrick Aepli, Amman Thomas, Claudia Anderegg, Anca-Teodora Antonino, Eva Archanioti, Eviano Arrigoni, Diana Bakker de Jong, Bruno Balsiger, Polat Bastuerk, Peter Bauerfeind, Andrea Becocci, Dominique Belli, Jose M. Bengoa, Luc Biedermann, Janek Binek, Mirjam Blattmann, Stephan Boehm, Tujana Boldanova, Jan Borovicka, Christian P. Braegger, Stephan Brand, Lukas Brugger, Simon Brunner, Patrick Buehr, Bernard Burnand, Sabine Burk, Emanuel Burri, Sophie Buyse, Dahlia-Thao Cao, Ove Carstens, Dominique H. Criblez, Sophie Cunningham, Fabrizia D'Angelo, Philippe de Saussure, Lukas Degen, Joakim Delarive, Christopher Doerig, Barbara Dora, Susan Drerup, Mara Egger, Ali El-Wafa, Matthias Engelmann, Jessica Ezri, Christian Felley, Markus Fliegner, Nicolas Fournier, Montserrat Fraga, Pascal Frei, Remus Frei, Michael Fried, Florian Froehlich, Raoul Ivano Furlano, Luca Garzoni, Martin Geyer, Laurent Girard, Marc Girardin, Delphine Golay, Ignaz Good, Ulrike Graf Bigler, Beat Gysi, Johannes Haarer, Marcel Halama, Janine Haldemann, Pius Heer, Benjamin Heimgartner, Beat Helbling, Peter Hengstler, Denise Herzog, Cyrill Hess, Roxane Hessler, Klaas Heyland, Thomas Hinterleitner, Claudia Hirschi, Petr Hruz, Carolina Khalid-de Bakker, Stephan Kayser, Celine Keller, Christina Knellwolf (-Grieger), Christoph Knoblauch, Henrik Koehler, Rebekka Koller, Claudia Krieger(-Grubel), Patrizia Kunzler, Rachel Kusche, Frank Serge Lehmann, Andrew J. Macpherson, Michael Manz, Astrid Marot, Remy Meier, Christa Meyenberger, Pamela Meyer, Benjamin Misselwitz, Patrick Mosler, Christian Mottet, Beat Muellhaupt, Leilla Musso, Michaela Neagu, Cristina Nichita, Jan Niess, Andreas Nydegger, Nicole Obialo, Diana Ollo, Cassandra Oropesa, Ulrich Peter, Daniel Peternac, Laetitia Marie Petit, Daniel Pohl, Marc Porzner, Claudia Preissler, Nadia Raschle, Ronald Rentsch, Alexandre Restellini, Sophie Restellini, Jean-Pierre Richterich, Frederic Ris, Branislav Risti, Marc Alain Ritz, Nina Roehrich, Jean-Benoit Rossel, Vanessa Rueger, Monica Rusticeanu, Markus Sagmeister, Gaby Saner, Bernhard Sauter, Mikael Sawatzki, Michael Scharl, Martin Schelling, Susanne Schibli, Hugo Schlauri, Dominique Schluckebier, Daniela Schmid, Sybille Schmid(-Uebelhart), Jean-Francois Schnegg, Alain Schoepfer, Vivianne Seematter, Frank Seibold, Mariam Seirafi, Gian-Marco Semadeni, Arne Senning, Christiane Sokollik, Joachim Sommer, Johannes Spalinger, Holger Spangenberger, Philippe Stadler, Peter Staub, Dominic Staudenmann, Volker Stenz, Michael Steuerwald, Alex Straumann, Bruno Strebel, Andreas Stulz, Michael Sulz, Aurora Tatu, Michela Tempia-Caliera, Joel Thorens, Kaspar Truninger, Radu Tutuian, Patrick Urfer, Stephan Vavricka, Francesco Viani, Jurg Voegtlin, Roland Von Kaenel, Dominique Vouillamoz, Rachel Vulliamy, Paul Wiesel, Reiner Wiest, Stefanie Woehrle, Samuel Zamora, Silvan Zander, Tina Wylie, Jonas Zeitz, Dorothee Zimmermann, Joerg Stelling, Andrew J. Macpherson
Article
Immunology
Hannah E. Scales, Gavin R. Meehan, Alan J. Hayes, Robert A. Benson, Emma Watson, Anne Walters, Michio Tomura, Eugene Maraskovsky, Paul Garside, Adriana Baz Morelli, James M. Brewer
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Valerie Pittet, Pierre Michetti, Christoph Mueller, Christian P. Braegger, Roland von Kanel, Alain Schoepfer, Andrew J. Macpherson, Gerhard Rogler, Claudia Anderegg, Peter Bauerfeind, Christoph Beglinger, Stefan Begre, Dominique Belli, Jose M. Bengoa, Luc Biedermann, Beat Bigler, Janek Binek, Mirjam Blattmann, Stephan Boehm, Jan Borovicka, Nora Brunner, Patrick Buhr, Bernard Burnand, Emanuel Burri, Sophie Buyse, Matthias Cremer, Dominique H. Criblez, Philippe De Saussure, Lukas Degen, Joakim Delarive, Christopher Doerig, Barbara Dora, Gian Dorta, Mara Egger, Tobias Ehmann, Ali El-Wafa, Matthias Engelmann, Jessica Ezri, Christian Felley, Markus Fliegner, Nicolas Fournier, Montserrat Fraga, Pascal Frei, Remus Frei, Michael Fried, Florian Froehlich, Christian Funk, Raoul Ivano Furlano, Suzanne Gallot-Lavallee, Martin Geyer, Marc Girardin, Delphine Golay, Tanja Grandinetti, Beat Gysi, Horst Haack, Johannes Haarer, Beat Helbling, Peter Hengstler, Denise Herzog, Cyrill Hess, Klaas Heyland, Thomas Hinterleitner, Philippe Hiroz, Claudia Hirschi, Petr Hruz, Rika Iwata, Res Jost, Pascal Juillerat, Celine Keller, Christina Knellwolf, Christoph Knoblauch, Henrik Kohler, Rebekka Koller, Claudia Krieger-Grubel, Gerd Kullak-Ublick, Patrizia Kunzler, Markus Landolt, Rupprecht Lange, Frank Serge Lehmann, Andrew Macpherson, Philippe Maerten, Michel H. Maillard, Christine Manser, Michael Manz, Urs Marbet, George Marx, Christoph Matter, Remy Meier, Martina Mendanova, Pierre Michetti, Benjamin Misselwitz, Bernhard Morell, Patrick Mosler, Christian Mottet, Christoph Mueller, Pascal Mueller, Beat Mullhaupt, Claudia Munger-Beyeler, Leilla Musso, Andreas Nagy, Michaela Neagu, Cristina Nichita, Jan Niess, Andreas Nydegger, Nicole Obialo, Carl Oneta, Cassandra Oropesa, Ueli Peter, Daniel Peternac, Laetitia Marie Petit, Franziska Piccoli-Gfeller, Julia Beatrice Pilz, Valerie Pittet, Nadia Raschle, Ronald Rentsch, Sophie Restellini, Jean-Pierre Richterich, Sylvia Rihs, Marc Alain Ritz, Jocelyn Roduit, Daniela Rogler, Gerhard Rogler, Jean-Benoit Rossel, Vanessa Rueger, Gaby Saner, Bernhard Sauter, Mikael Sawatzki, Michela Schappi, Michael Scharl, Sylvie Scharl, Martin Schelling, Susanne Schibli, Hugo Schlauri, Sybille Schmid Uebelhart, Jean-Francois Schnegg, Alain Schoepfer, Frank Seibold, Mariam Seirafi, Gian-Marco Semadeni, David Semela, Arne Senning, Marc Sidler, Christiane Sokollik, Johannes Spalinger, Holger Spangenberger, Philippe Stadler, Michael Steuerwald, Alex Straumann, Bigna Straumann-Funk, Michael Sulz, Alexandra Suter, Joel Thorens, Sarah Tiedemann, Radu Tutuian, Stephan Vavricka, Francesco Viani, Jurg Vogtlin, Roland Von Kanel, Alain Vonlaufen, Dominique Vouillamoz, Rachel Vulliamy, Jurg Wermuth, Helene Werner, Paul Wiesel, Reiner Wiest, Tina Wylie, Jonas Zeitz, Dorothee Zimmermann
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)
Correction
Biochemistry & Molecular Biology
Bahtiyar Yilmaz, Pascal Juillerat, Ove Oyas, Charlotte Ramon, Francisco Damian Bravo, Yannick Franc, Nicolas Fournier, Pierre Michetti, Christoph Mueller, Markus Geuking, Valerie E. H. Pittet, Michel H. Maillard, Gerhard Rogler, Reiner Wiest, Jorg Stelling, Andrew J. Macpherson
Article
Immunology
Qingkun Liu, Emily M. Johnson, Rachel K. Lam, Qian Wang, Hong Bo Ye, Edward N. Wilson, Paras S. Minhas, Ling Liu, Michelle S. Swarovski, Stephanie Tran, Jing Wang, Swapnil S. Mehta, Xi Yang, Joshua D. Rabinowitz, Samuel S. Yang, Mehrdad Shamloo, Christoph Mueller, Michelle L. James, Katrin I. Andreasson
Article
Multidisciplinary Sciences
Frank Michael Lehmann, Nicole von Burg, Robert Ivanek, Claudia Teufel, Edit Horvath, Annick Peter, Gleb Turchinovich, Daniel Staehli, Tobias Eichlisberger, Mercedes Gomez de Aguero, Mairene Coto-Llerena, Michaela Prchal-Murphy, Veronika Sexl, Mohamed Bentires-Alj, Christoph Mueller, Daniela Finke
NATURE COMMUNICATIONS
(2020)
Article
Virology
Giuditta De Lorenzo, Rapeepat Tandavanitj, Jennifer Doig, Chayanee Setthapramote, Monica Poggianella, Ricardo Sanchez-Velazquez, Hannah E. Scales, Julia M. Edgar, Alain Kohl, James Brewer, Oscar R. Burrone, Arvind H. Patel
Summary: The study developed ZIKV subunit and virus-like particle (VLP)-based vaccines, which induced antibodies with a higher capacity to neutralize virus infection and protected animals from lethal challenge with both the African and Asian lineages of ZIKV. The engineered immunogens reduced the potential to induce antibody-dependent enhancement (ADE) of infection and showed promising efficacy in comparison with the wild-type derivatives.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Caio S. Bonilha, Robert A. Benson, Hannah E. Scales, James M. Brewer, Paul Garside
Summary: JAM-A is an adhesion molecule present in various cell types, playing a functional role in interactions between CD4(+) T cells and DCs during T cell priming as a positive regulator of Th1 differentiation.
IMMUNOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Lijuan Ma, Thomas Andrieu, Brett McKinnon, Lea Duempelmann, Ren-Wang Peng, Carlos Wotzkow, Christoph Mueller, Michael D. Mueller
Summary: This study found a negative correlation between low expression of progesterone receptors (PR) and epithelial-to-mesenchymal transition (EMT) in endometriosis lesions. In both in vitro and in vivo experiments, EMT leads to downregulation of PR gene expression by upregulating EMT transcription factors like SNAI1 and SNAI2, potentially resulting in progesterone resistance.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Daniel Zysset, Matteo Montani, Johannes Spalinger, Susanne Schibli, Inti Zlobec, Christoph Mueller, Christiane Sokollik
Summary: Solitary juvenile polyps (JP) exhibit a benign disease course with low recurrence rate but with signs of intestinal inflammation. Study results showed predominant accumulation of neutrophils and eosinophils in JP, with increased levels of CXCL8, CXCL5, and CCL11 transcripts suggesting enhanced recruitment of these cell types. Proinflammatory cytokines and inflammation-amplifying receptors were higher in JP compared with IBD, indicating a different immune response mechanism.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Review
Cell Biology
Juliana Barreto de Albuquerque, Christoph Mueller, Bilgi Gungor
Summary: Tissue-resident memory T (T-RM) cells play a crucial role in rapid immune protection and chronic inflammatory disorders, with potential for immunopathological reactions. Researchers focus on the role of T-RM cells in the intestine and discuss potential therapeutic strategies to interfere with diseases mediated by these cells.
Article
Medicine, Research & Experimental
Catriona T. Prendergast, Robert A. Benson, Hannah E. Scales, Caio Santos Bonilha, John J. Cole, Iain McInnes, James M. Brewer, Paul Garside
Summary: This study used mouse models and RNA-Seq analysis to identify key molecular pathways and genes regulating immune cell migration, and discovered specific genes associated with rheumatoid arthritis. The findings are important for identifying therapeutic targets for arthritis and other inflammatory disorders.
Article
Microbiology
Teerawit Audshasai, Jonathan A. Coles, Stavros Panagiotou, Shadia Khandaker, Hannah E. Scales, Morten Kjos, Murielle Baltazar, Julie Vignau, James M. Brewer, Aras Kadioglu, Marie Yang
Summary: Using two-photon imaging, we demonstrate that pneumococci and microspheres can translocate from the nasal cavity to the meninges of mice within minutes of inhaled delivery. This suggests the existence of an inward flow of fluid connecting the nasopharynx to the meninges. Our findings provide new insights into the mechanisms of pathogens invading the central nervous system and have implications for drug delivery and air pollution-related brain damage.
Article
Medicine, Research & Experimental
Jonathan Noonan, Steven M. Asiala, Gianluca Grassia, Neil MacRitchie, Kirsten Gracie, Jake Carson, Matthew Moores, Mark Girolami, Angela C. Bradshaw, Tomasz J. Guzik, Gavin R. Meehan, Hannah E. Scales, James M. Brewer, Iain B. McInnes, Naveed Sattar, Karen Faulds, Paul Garside, Duncan Graham, Pasquale Maffia