Article
Multidisciplinary Sciences
Abera Abdeta, Adane Bitew, Surafel Fentaw, Estifanos Tsige, Dawit Assefa, Tadesse Lejisa, Yordanos Kefyalew, Eyasu Tigabu, Martin Evans
Summary: The study detected a high prevalence of multidrug-resistant and extremely drug-resistant carbapenemase-producing gram-negative bacteria, particularly among intensive care unit patients at healthcare facilities. This highlights the increasing difficulty in clinical management of infected patients and the need for last-resort antibiotics, potentially worsening the global antimicrobial resistance crisis. Robust antimicrobial resistance monitoring and infection prevention and control programs are necessary.
Article
Infectious Diseases
Jordan E. Sealey, Ashley Hammond, Oliver Mounsey, Virginia C. Gould, Kristen K. Reyher, Matthew B. Avison
Summary: This study compares faecal third-generation cephalosporin-resistant (3GC-R) Escherichia coli isolates from dogs living in a city and a rural area, and also compares isolates from dogs, cattle, and humans in these regions. Risk factors associated with 3GC-R E. coli carriage in dogs were determined. The results indicate that in rural dogs, carriage of 3GC-R E. coli, particularly CTX-M producers, is phylogenetically associated with interaction with local cattle and epidemiologically associated with feeding raw meat. In urban dogs, sources of 3GC-R E. coli appear to be more varied and include environments such as rivers.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Environmental Sciences
Vinay Rajput, Rakeshkumar Yadav, Mahesh S. Dharne
Summary: This study investigated the impact of urban rivers in Pune, India on peri-urban rivers, revealing higher diversity of antibiotic resistance genes in urban river sections and detection of dissemination of antibiotic resistance genes from polluted urban rivers to downstream peri-urban rivers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Claudia Medina, Olivia Ginn, Joe Brown, Freddy Soria, Carolina Garvizu, Angela Salazar, Alejandra Tancara, Jhoana Herrera
Summary: The study found that microbiological pollution associated with the Choqueyapu River and the lack of a wastewater treatment plant in La Paz city pose a threat to public health. Air samples collected near the river showed a high concentration of Enterobacteriaceae, with the highest antibiotic resistance observed for tetracycline and sulfamethoxazole-trimethoprim. Additionally, a comparison with previous pilot studies revealed seasonal effects on airborne Enterobacteriaceae concentration and changes in antibiotic resistance levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Green & Sustainable Science & Technology
Paul Hutchings, Simon Willcock, Kenneth Lynch, Dilshaad Bundhoo, Tim Brewer, Sarah Cooper, Daniel Keech, Sneha Mekale, Prajna Paramita Mishra, Alison Parker, Charlie M. Shackleton, Kongala Venkatesh, Dolores Rey Vicario, Indunee Welivita
Summary: This article discusses the simplification of the urban-rural divide in research and highlights the importance of peri-urban landscapes and service provisions. It presents a framework to explain the processes of rapid change and service provision decline in peri-urban areas in the Global South, and emphasizes the significance of systems theory in studying peri-urban issues.
NATURE SUSTAINABILITY
(2022)
Article
Veterinary Sciences
John Mankhomwa, Rachel Tolhurst, Eunice M'biya, Ibrahim Chikowe, Pemphero Banda, Jimmy Mussa, Henry Mwasikakata, Victoria Simpson, Nicholas Feasey, Eleanor E. MacPherson
Summary: The use of antibiotics in meat production has been identified as a driver of antimicrobial resistance in both animals and humans. This study aimed to understand antibiotic use practices in farming households in Blantyre, with a focus on small-scale intensive farming. The findings suggest that antibiotic use is more common in households engaged in small-scale intensive farming, driven by economic and social factors. Interventions should take a holistic approach, including improving access to affordable veterinary services and promoting appropriate antibiotic use.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Ravalona Jessica Zemtsa, Michel Noubom, Luria Leslie Founou, Brice Davy Dimani, Patrice Landry Koudoum, Aurelia Djeumako Mbossi, Charles Kouanfack, Raspail Carrel Founou
Summary: This study investigated the prevalence and characteristics of multidrug-resistant Enterobacterales (MDR-E) and extended spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) in women living with HIV in Cameroon. The results showed a high prevalence of MDR-E and ESBL-PE in these women, with resistance observed against commonly used antibiotics. The study highlights the need for a monitoring system for antimicrobial resistant bacteria and strengthened infection prevention control strategies.
Article
Infectious Diseases
Sara Comini, Gabriele Bianco, Matteo Boattini, Giuliana Banche, Guido Ricciardelli, Valeria Allizond, Rossana Cavallo, Cristina Costa
Summary: This study evaluated a rapid diagnostic algorithm based on MALDI-TOF MS, lateral flow immunoassays (LFIAs), and molecular testing for the identification of Gram-negative species and detection of beta-lactamase and carbapenemase genes directly from positive blood cultures (BCs). The results showed that this algorithm allowed reliable species identification and timely detection of resistance markers. Integration of molecular testing further improved the detection of specific resistance genes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Pharmacology & Pharmacy
Syed Mohd Danish Rizvi, Amr Selim Abu Lila, Afrasim Moin, Talib Hussain, Mohammad Amjad Kamal, Hana Sonbol, El-Sayed Khafagy
Summary: The advent of new antibiotics has helped control severe bacterial infections, but inappropriate use and resistance mechanisms still pose challenges. Extended-spectrum beta-lactamases (ESBLs) genes have become one of the most common approaches for bacteria to develop resistance. Nanotechnology, specifically gold nanoparticles (AuNPs), has shown potential in converting unresponsive antibiotics into potent ones against resistant strains.
Article
Microbiology
Delia Gambino, Valeria Gargano, Gaspare Butera, Sonia Sciortino, Mariangela Pizzo, Giuseppa Oliveri, Cinzia Cardamone, Chiara Piraino, Giovanni Cassata, Domenico Vicari, Antonella Costa
Summary: The study focused on antibiotic susceptibility profiles and ESBL production of Salmonella spp. strains, revealing the presence of MDR strains and ESBL producers, posing potential risks in food safety. Further research on antibiotic resistance genes in foodborne strains, especially from a One Health perspective, is warranted.
Article
Multidisciplinary Sciences
Mekdes Alemu Tola, Negga Asamene Abera, Yonas Mekonnen Gebeyehu, Surafel Fentaw Dinku, Kassu Desta Tullu
Summary: This study in Addis Ababa, Ethiopia, found a high prevalence of ESBL producing Escherichia coli and Klebsiella pneumoniae fecal carriage among children under five, with high levels of multidrug resistance. Factors associated with higher ESBL carriage included lower maternal education and drinking tap water. Routine screening for ESBL is crucial for early detection and appropriate antibiotic selection.
Article
Multidisciplinary Sciences
Mekdes Alemu Tola, Negga Asamene Abera, Yonas Mekonnen Gebeyehu, Surafel Fentaw Dinku, Kassu Desta Tullu
Summary: The prevalence of ESBL producing E. coli and K. pneumoniae fecal carriage among children under five years in Addis Ababa, Ethiopia was found to be 17.1%. These isolates showed high levels of multidrug resistance and were associated with lower educational level of mothers and drinking tap water in children. Routine screening for ESBL is crucial for early detection and appropriate antibiotic selection.
Article
Infectious Diseases
Candace Guzman-Cole, Fabian Santiago, Sona Garsevanyan, Suzanne Sindi, Miriam Barlow
Summary: This study revealed that local selective pressures have a greater influence on the population structure of resistance genes in bacterial populations than migration, indicating the potential for antibiotic resistance to be controlled at a regional level.
Article
Environmental Sciences
Emily K. Rousham, Muhammad Asaduzzaman, T. I. M. Amin Uddin Mozmader, Mohammed Badrul Amin, Mahdia Rahman, Muhammed Iqbal Hossain, Md Rayhanul Islam, Zahid Hayat Mahmud, Leanne Unicomb, Mohammad Aminul Islam
Summary: The study revealed a high prevalence of ESBL-EC colonization in humans, but it was not significantly associated with poultry exposure. In these community settings, bidirectional transmission of antibiotic resistance between humans, poultry, and the environment is likely to occur, highlighting the importance of One Health mitigation strategies.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Review
Medicine, General & Internal
Herve Boutal, Christian Moguet, Lilas Pommies, Stephanie Simon, Thierry Naas, Herve Volland
Summary: The global spread of antimicrobial resistant bacteria poses a significant public health concern. Detecting and identifying resistance mechanisms is challenging, but lateral flow assays (LFA) have emerged as cost-effective and rapid tools to combat antimicrobial resistance. This review examines the versatility and performance of LFA for detecting antimicrobial resistance, focusing on beta-lactamase triggers. It also discusses potential modifications to broaden clinical sensitivity and improve sample handling processes. Additionally, the use of LFA in detecting amplified genetic determinants of antimicrobial resistance is explored.
Article
Immunology
Kumaran Vadivel, Ramamurthy Mageshbabu, Sathish Sankar, Amita Jain, Vivekanandan Perumal, Padma Srikanth, Ghosh Asit Ranjan, Aravindan Nair, Eric A. F. Simoes, Balaji Nandagopal, Gopalan Sridharan
INDIAN JOURNAL OF MEDICAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Sathish Sankar, Nithiyanandan Saravanan, Prashanth Rajendiran, Mageshbabu Ramamurthy, Balaji Nandagopal, Gopalan Sridharan
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Mageshbabu Ramamurthy, Sathish Sankar, Asha Mary Abraham, Balaji Nandagopal, Gopalan Sridharan
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Letter
Dentistry, Oral Surgery & Medicine
Sathish Sankar, Pitchaipillai Sankar Ganesh, Vasanth Dhakshinamoorthy
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Letter
Oncology
Sathish Sankar
Article
Medicine, Research & Experimental
Sathish Sankar, Monal Yuwanati, Pitchaipillai Sankar Ganesh
Summary: Different therapy approaches are used to treat oral squamous cell carcinoma (OSCC), however, cancer's rising prevalence owing to recurrence and its dismal outlook has resulted in a low 5-year survival rate. Oral microbiota promotes angiogenesis and carcinoma formation, and is closely associated with OSCC. N-Acyl-homoserine lactones (AHLs), the main quorum sensing (QS) molecules, facilitate biofilm formation and are thought to be crucial for OSCC growth and metastasis. Investigating the potential of using small-molecule AHL-binding inhibitors as therapeutics against biofilm-producing infections is underway.
MEDICAL HYPOTHESES
(2023)
Editorial Material
Immunology
Sathish Sankar
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Sathish Sankar, Pitchaipillai Sankar Ganesh, Suganya Subramaniam, Esaki M. Shankar, Monal Yuwanati, Rajakumar Govindasamy, Muthu Thiruvengadam
Summary: In biofilm formation, pathogens use a cell-cell communication system called quorum sensing to coordinate and regulate bacterial virulence and host immune response. This review focuses on host responses, clinical implications, and therapeutic approaches against P. aeruginosa biofilms. Due to the pathogen's high antibiotic resistance and biofilm-forming ability, treatment complications can lead to significant morbidity and mortality rates worldwide. Despite available intervention strategies, there is a lack of effective therapeutic options to control biofilm formation. This review discusses the understanding of quorum sensing-associated virulence factors and key therapeutic interventions to overcome P. aeruginosa biofilm menace.
MICROBIAL PATHOGENESIS
(2023)
Review
Biology
Rajakumar Govindasamy, Ekambaram Gayathiri, Sathish Sankar, Baskar Venkidasamy, Palanisamy Prakash, Kaliaperumal Rekha, Varsha Savaner, Abirami Pari, Natesan Thirumalaivasan, Muthu Thiruvengadam
Summary: Nanotechnology has the potential to bring about revolutionary changes in various fields, and genetically engineered cyanobacteria have emerged as potential candidates for synthesizing nanoparticles. Scientists have shown great interest in the applications of genetically engineered cyanobacteria in nanotechnology, discussing their challenges and future prospects.
Article
Immunology
Sathish Sankar, Vasanth Dhakshinamoorthy, Govindasamy Rajakumar
Summary: Cytomegalovirus is a widespread infection that affects the majority of the population globally. Congenital CMV infection acquired during pregnancy can lead to severe neurodevelopmental sequelae and high mortality rate. The role of PARP-1 protein in CMV infection and its potential as a target for PARP inhibitors in preventing neurological sequelae is yet to be fully understood. Further research on the role of PARP in CMV neuropathogenesis can contribute to the development of effective interventions against neurodegeneration.
MICROBIAL PATHOGENESIS
(2023)
Letter
Public, Environmental & Occupational Health
Sathish Sankar
INDIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Sathish Sankar
Summary: A multi-epitope candidate vaccine was designed using the combination of mosquito salivary proteins OBP 22 and OBP 10, showing promise for protection against arboviruses. This study provides new directions for vaccine design and highlights the need for further clinical validation.
JOURNAL OF VECTOR BORNE DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Prashanth Rajendiran, Nithiyanandan Saravanan, Mageshbabu Ramamurthy, Sathish Sankar, Rajasekar Aruliah, Balaji Nandagopal, Gopalan Sridharan
Summary: An in-house multiplex real-time PCR assay was developed for the detection of TORCH-S agents causing congenital infection among pregnant women. The assay was standardized and validated, providing a rapid, sensitive, and specific technique for screening TORCH-S infection in women with histories of abnormal pregnancies.
INDIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Mathematical & Computational Biology
Sathish Sankar, Mageshbabu Ramamurthy, Subramanian Suganya, Balaji Nandagopal, Gopalan Sridharan
Article
Mathematical & Computational Biology
Gopalsamy Sarangan, Seema A. Nayar, Monika Mani, Sudharsana Sundarrajan, Sathish Sankar, Gunasekaran Palani, Gracy Fathima Selvaraj, Jayachandran Damodharan, Karuppaiah Muthumani, Padma Srikanth