Article
Microbiology
Mireia Lopez-Siles, Zaira Moure, Aly Salimo Muadica, Sergio Sanchez, Raquel Cruces, Alicia avila, Noelia Lara, Pamela Carolina Koster, Alejandro Dashti, Jesus Oteo-Iglesias, David Carmena, Michael J. McConnell
Summary: This study aimed to identify external factors associated with ESBL-E carriage and characterize clonal relationships and mechanisms of resistance in ESBL-E isolates. Among the 887 healthy children surveyed, 24 ESBL-E strains were detected, mainly Escherichia coli. The prevalence of ESBL-E in children was found to be lower than the average colonization rate previously observed in Europe for both children and adults, with CTX-M being the most frequently identified ESBL type.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children in the ESBL group were more likely to have a history of recent antibiotic use or prophylactic antibiotic use and experience recurrent UTIs. Most children with fUTI experience clinical improvement regardless of the choice of antibiotic.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Takuma Ohnishi, Yoshinori Mishima, Tomomi Naito, Nozomi Matsuda, Shohei Ariji, Daisuke Umino, Kikuko Tamura, Hajime Nishimoto, Keiji Kinoshita, Naonori Maeda, Azusa Kawaguchi, Ryuta Yonezawa, Shigenao Mimura, Hiroyuki Fukushima, Kenji Nanao, Makoto Yoshida, Toshio Sekijima, Isamu Kamimaki
Summary: This study aimed to clarify the risk factors and treatment strategies for febrile urinary tract infection (fUTI) caused by ESBL-producing bacteria in Japanese children. The results showed that children with a history of recent antibiotic use or prophylactic antibiotic use and recurrent UTIs were more likely to have fUTI caused by ESBL-producing bacteria. Regardless of the choice of antibiotic, most children with fUTI experienced clinical improvement.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Demissew Shenkute, Melese Hailu Legese, Berhanu Yitayew, Asaye Mitiku, Getabalew Engidaye, Saba Gebremichael, Daniel Asrat, Yimtubezinash Woldeamanuel
Summary: This study revealed a high prevalence of gastrointestinal colonization of ESBL-PE among hospitalized patients at Debre Berhan Comprehensive Hospital, with E. coli and K. pneumoniae being the predominant strains. The resistance rates to antibiotics like ampicillin were also high. History of antibiotic use, admission in neonatal intensive care unit, and presence of chronic disease were identified as independent risk factors for ESBL-PE fecal carriage.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Emergency Medicine
Ralphe Bou Chebl, Mohamad Assaf, Nadim Kattouf, Samer Abou Arbid, Saadeddine Haidar, Mirabelle Geha, Maha Makki, Hani Tamim, Gilbert Abou Dagher
Summary: The prevalence of ESBL organisms in urinary tract infections was found to be 24.9%. Predictors of an ESBL UTI infection included antibiotic use in the last 90 days and a history of ESBL producing isolate at any site in the previous year. Based on these findings, modifying initial empiric antibiotic treatment for UTI patients with these risk factors could be considered.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Microbiology
Teresita d. J. Bello Gonzalez, Arie Kant, Quillan Dijkstra, Francesca Marcato, Kees van Reenen, Kees T. Veldman, Michael S. M. Brouwer
Summary: This study aimed to characterize the changes in fecal carriage of Extended-Spectrum beta-Lactamase (ESBL) producing Enterobacterales (ESBL-PE) over time in Dutch veal calves. The study found a decrease in fecal carriage of cefotaxime-resistant Escherichia coli isolates and an increase of cefotaxime-resistant Klebsiella pneumoniae isolates during the rearing period. The ESBL genes identified differed between the two bacteria. The study also discovered clonal spread of ESBL-K. pneumoniae in some animals.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Guojing Wang, Yu Zhu, Shana Feng, Baojun Wei, Yujuan Zhang, Jingzhi Wang, Shengkai Huang, Shengling Qin, Xuan Liu, Bing Chen, Wei Cui
Summary: The study aimed to investigate the prevalence and risk factors of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae related urinary tract infections (UTI) in adult cancer patients. The results showed that tumor metastasis, urological cancer, indwelling catheter, and surgery or invasive manipulation were independent risk factors for ESBL UTI. Therefore, clinicians should be alert to the occurrence of ESBL UTI, especially for patients with urological cancer or metastatic tumors, and take necessary measures to prevent and treat such infections.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Daniel T. Anderson, Benjamin Albrecht, K. Ashley Jones, Jesse T. Jacob, Mary Elizabeth Sexton, Zanthia Wiley, William C. Dube, Benjamin Lee, Sujit Suchindran
Summary: A retrospective cohort study found that noncarbapenem beta-lactam (NCBL) treatment for ESBL urinary tract infections (UTIs) had similar or even better outcomes compared to carbapenem treatment in terms of hospital length of stay, clinical and microbiological response, duration of therapy, and rate of relapsed infections.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Karzan Taha Abubaker, Khanda Abdulateef Anwar
Summary: This study investigated the prevalence of antibiotic resistance patterns and integron classes among bacterial isolates in patients with urinary tract infections in Sulaimani, Iraq. The results showed that most bacterial isolates from patients with UTI produced class I and II integrons genes with favourable ESBL properties.
Article
Immunology
Isabelle Vock, Lisandra Aguilar-Bultet, Adrian Egli, Pranita D. Tamma, Sarah Tschudin-Sutter
Summary: Majority of infections in hospitalized patients colonized with ESBL-PE are not caused by ESBL-PE. Site of infection and patient-level exposures may serve as useful predictors for nESBI,-PE infections, potentially guiding empiric treatment recommendations.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Belen Gutierrez-Gutierrez, Elena Perez-Nadales, Salvador Perez-Galera, Mario Fernandez-Ruiz, Jordi Carratala, Isabel Oriol, Elisa Cordero, Jose Antonio Lepe, Ban Hock Tan, Laura Corbella, Mical Paul, Alejandra M. Natera, Miruna D. David, Miguel Montejo, Ranganathan N. Iyer, Ligia Camera Pierrotti, Esperanza Merino, Seema Mehta Steinke, Meenakshi M. Rana, Patricia Munoz, Alessandra Mularoni, Christian van Delden, Paolo Antonio Grossi, Elena Maria Seminari, Filiz Gunseren, Erika D. Lease, Emmanuel Roilides, Jesus Fortun, Hande Arslan, Julien Coussement, Zeliha Kocak Tufan, Benoit Pilmis, Marco Rizzi, Belen Loeches, Britt Marie Eriksson, Edson Abdala, Fabio Soldani, Warren Lowman, Wanessa Trindade Clemente, Marta Bodro, Maria Carmen Farinas, Esra Kazak, Luis Martinez-Martinez, Jose Maria Aguado, Julian Torre-Cisneros, Alvaro Pascual, Jesus Rodriguez-Bano
Summary: The efficacy of ertapenem in treating B-UTI caused by ESBL-E in KT recipients remains inconclusive, with similar clinical cure rates to meropenem. Ertapenem may offer some advantages in certain scenarios, as indicated by propensity score matching and DOOR analyses.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Nishan Kunnummal Purayil, Vamanjore A. Naushad, Prem Chandra, Prakash Joseph, Zahida Khalil, Muhammad Zahid, Godwin Wilson, Muhammed Kunhi Kayakkool, Basma Ayari, Sajid Chalihadan, Emad Bashier Elmagboul, Sanjay H. Doiphode
Summary: The purpose of this study was to investigate the association between proton pump inhibitor (PPI) use and the risk of urinary tract infection (UTI) caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL). A retrospective cross-sectional study was conducted comparing ESBL-UTI patients with gram-negative bacteria (GNB) UTI patients and UTI patients caused by miscellaneous organisms. The results showed an association between PPI exposure within 3 months prior to admission and increased risk of ESBL-UTI. Esomeprazole showed a positive association, while Lansoprazole had an inverse association with ESBL-UTI. It is suggested that restricting the use of PPIs may be beneficial in combating antimicrobial resistance.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
Rumyana Markovska, Petya Stankova, Temenuga Stoeva, Dobrinka Ivanova, Daniela Pencheva, Radka Kaneva, Lyudmila Boyanova
Summary: This study investigated ESBL-producing Enterobacterales isolates in patients and hospital staff in two Bulgarian hospitals, finding a high prevalence of these bacteria with various resistance genes and plasmid types, indicating a significant presence of multidrug-resistant bacteria in the environment.
Article
Oncology
Wubalech Temsegen, Kasahun Gorems, Mekidim Mekonnen, Diriba Fufa, Tesfaye Kassa
Summary: This study revealed alarmingly high carriage rates of ESBL and CPE among all study participants. The isolates also showed increased resistance rates to alternative drugs and had multiple antibiotic-resistant patterns. Hence, it is important to emphasize strict adherence to antimicrobial stewardship program as well as infection prevention and control practices.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Infectious Diseases
Tyler J. Stone, Abdullah Kilic, John C. Williamson, Elizabeth L. Palavecino
Summary: The in vitro activity of omadacycline and comparator antibiotics against clinical ESBL-producing and non-ESBL-producing E. coli and K. pneumoniae urinary isolates was evaluated. Results showed that 54.9% of all ESBL-producing isolates and 74.5% of ESBL-producing E. coli isolates were susceptible to omadacycline. Overall, omadacycline and nitrofurantoin were the most active agents for treating UTI caused by ESBL-producing E. coli.
