Article
Hospitality, Leisure, Sport & Tourism
Oya Yigitturk, Faruk Turgay, Servet Kizildag, Dua Ozsoylu, Gorkem Aybars Balci
Summary: This study aimed to investigate the effects of hypoxic underwater rugby training on PON1 enzyme activity and oxLDL levels, as well as the role of PON1-Q192R and PON1-L55M polymorphisms. The results showed that hypoxic training led to significant oxidative stress and antioxidant response, resulting in increased PON1 and PON3 activity. The activity of PON1 and ARE was affected by PON1-Q192R and PON1-L55M polymorphisms, and improvements in PON1 activity were observed in QQ and LL genotype groups. However, hypoxic training had a detrimental effect on ARE activity in LL and Rc groups.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Medicine, General & Internal
Katarzyna Blizniewska-Kowalska, Piotr Galecki, Kuan-Pin Su, Angelos Halaris, Janusz Szemraj, Malgorzata Galecka
Summary: By evaluating the expression levels of antioxidant enzyme genes in patients with depressive disorders, we found that the expression of PON2 and PON3 genes at the protein level was significantly higher, while the expression of the MPO gene was significantly lower in depressive patients compared to healthy controls. However, these findings are not consistent with other studies, suggesting the need for larger and well controlled studies to confirm the utility of these genes as biomarker candidates for depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Tugrul Demirel, Ilhan Yaylim, Hayriye Arzu Ergen, Mustafa Kayihan Gunay, Yaman Tekant, Turgay Isbir
Summary: The study of Paraoxonase 1 (PON1) polymorphism and enzyme activity in colorectal cancer patients revealed that the AA genotype was the most common in this group, with decreased enzyme activity possibly contributing to cancerous DNA damage. Further research with more patients considering the location and stage of colorectal tumors is warranted to gain a broader understanding of the role of this polymorphism and enzyme activity in cancer formation.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2021)
Review
Biochemistry & Molecular Biology
Sana Ashiq, Kanwal Ashiq
Summary: This study analyzed the association of PON1 gene polymorphisms with CAD and found that the Q192R polymorphism increased the risk of CAD while the L55M polymorphism showed no significant association. More studies with larger sample sizes are needed for a more definitive conclusion in the future.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
A. A. Hernandez-Collazo, Oscar Perez-Mendez, Victoria Lopez-Olmos, V. Delgado-Rizo, J. F. Munoz-Valle, Erika Martinez-Lopez, D. G. Villanueva-Quintero, Carolina Dominguez-Diaz, Mary Fafutis-Morris, Anabell Alvarado-Navarro
Summary: The study aimed to determine the association of rs662 (A > G) and rs854560 (A > T) PON1 polymorphisms with psoriasis susceptibility in Western Mexico population. The results showed that the G allele of rs662 (A > G) is associated with risk for psoriasis, while the T allele of rs854560 (A > T) is associated with low susceptibility to psoriasis. It suggests that carriers of G allele of rs662 (A > G) present a greater susceptibility to psoriasis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ercan Cinar, Ersin Akgollu, Guzide Yucebilgic, Ramazan Bilgin, Semra Paydas
Summary: This study investigated the effects of polymorphisms in the PON1 gene and PON1 enzyme activity on NHL. The results showed that carrying specific alleles of L55M and Q192R polymorphisms may increase the risk of developing NHL, and NHL patients generally had lower enzyme activity. This study is the first to explore the impact of these polymorphisms on NHL disease, and suggests further research in larger populations.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Ayla Solmaz Avcikurt, Nahit Gencer, Hasmet Yazici
Summary: The study indicates that the Q192R polymorphism of the PON1 gene is associated with nasal-polyp disease, with the QQ genotype showing a higher risk and the QR genotype showing a lower risk.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Rheumatology
Sangmee Sharon Bae, Ani Shahbazian, Jennifer Wang, Ilana Golub, Buzand Oganesian, Tyler Dowd, Beata Vayngortin, Ryan Wang, David Elashoff, Srinivasa T. Reddy, Christina Charles-Schoeman
Summary: This study found that the activity of PON1 is significantly reduced in patients with IIM compared to healthy controls, and it is inversely associated with disease activity and the presence of severe ILD. The PON1 Q192R polymorphism is strongly linked to the paraoxonase activity of PON1 in IIM, and patients with the PON1 QQ genotype may have better disease outcomes in IIM.
Article
Oncology
Sara Diels, Bart Cuypers, Asta Tvarijonaviciute, Bruno Derudas, Evelien Van Dijck, An Verrijken, Luc F. Van Gaal, Kris Laukens, Philippe Lefebvre, Jose J. Ceron, Sven Francque, Wim Vanden Berghe, Wim Van Hul
Summary: Our study utilized a targeted multi-omics approach to investigate the interplay between PON1 genetic variants, promoter methylation, expression profile and enzymatic activity in relation to obesity-associated fatty liver disease. The findings revealed a significant correlation between alterations in PON1 status and waist-to-hip ratio as well as relevant features of liver pathology. Furthermore, a strong association of the regulatory polymorphism rs705379:C > T with more severe liver disease was identified, indicating the importance of combined genetic and epigenetic PON1 regulation in disease progression.
CLINICAL EPIGENETICS
(2021)
Article
Biochemistry & Molecular Biology
Ali Khattib, Sanaa Musa, Majdi Halabi, Tony Hayek, Soliman Khatib
Summary: This study examined the effects of lipids on PON1 enzyme activity and LDL oxidation using structure-activity relationship methods. The results showed that certain lipids significantly increased PON1 activity and inhibited LDL oxidation.
Correction
Environmental Sciences
Chia -Huang Chang, Boopathi Subramani, Ching-Jung Yu, Jung-Chieh Du, Hsien-Chih Chiou, Jia-Woei Hou, Winnie Yang, Chian-Feng Chen, Ying-Sheue Chen, Betau Hwang, Mei-Lien Chen
Summary: This study aimed to investigate the relationship between exposure to organophosphate pesticides (OPPs) and the risk of attention deficit hyperactivity disorder (ADHD) in children. The results showed that children with ADHD had higher levels of OP metabolites and lower levels of PON1 methylation than the control group, suggesting that chronic sub-acute exposure to OPPs could influence PON1 methylation levels.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Aneta Otocka-Kmiecik, Monika Orlowska-Majdak, Robert Stawski, Urszula Szkudlarek, Gianluca Padula, Szymon Galczynski, Dariusz Nowak
Summary: Exercise can increase plasma antioxidant capacity by stimulating antioxidant enzymes. This study measured the effect of acute exercise on ARE activity of the PON1 enzyme and found that ARE activity remained stable during exercise but decreased after exercise when standardized for PON1 concentration. The ratio of ARE/PON1c returned to baseline levels during rest after each exercise session. Individuals with lower pre-exercise ARE activity may experience a higher inflammatory response to vigorous exercise.
Article
Environmental Sciences
Angeles C. Ochoa-Martinez, Yesenia Araiza-Gamboa, Jose A. Varela-Silva, Sandra T. Orta-Garcia, Leticia Carrizales-Yanez, Ivan N. Perez-Maldonado
Summary: This study evaluated the impact of gene-environment interaction on serum levels of cardiovascular disease biomarkers in Mexican women, finding significant associations between arsenic exposure, PON1 Q192R polymorphism, and CVDs biomarkers. Results showed higher concentrations of CVDs biomarkers in R allele carriers, highlighting the importance of gene-environment interactions in cardiovascular disease research.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Environmental Sciences
Thais Fernandes Mendonca Mota, Wesley Lima Oliveira, Sandrieli Goncalves, Marina Wust Vasconcelos, Karina Silvia Beatriz Miglioranza, Nedia Castilhos Ghisi
Summary: Acephate, a moderately toxic pesticide, is widely used for pest control in agriculture and domestic settings despite being highly toxic to mammals and birds through its metabolite methamidophos. This research aimed to analyze the intellectual production and identify the gaps and trends in scientific research on acephate through a scientometric analysis. Results showed that the majority of studies focused on acephate's efficiency, followed by toxicity and residue detection methods. The USA, China, India, Brazil, and Japan published the most literature on acephate. Keywords such as pesticides, toxicity, insecticide resistance, and residue were commonly used. However, there is a need for more research on chronic toxicity, genotoxicity, cytotoxicity, metabolic and biochemical pathways, and genes related to acephate action and biodegradation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Abdolkarim Mahrooz, Yasaman Shokri, Atena Variji, Mehryar Zargari, Ahad Alizadeh, Ehsan Mehtarian
Summary: Developing laboratory assays to evaluate HDL functions and improving cardiovascular disease risk assessment by investigating new cardiometabolic risk factors based on substituting paraoxonase 1 (PON1) as a critical enzyme in the functionality of HDL for that of HDL-C may help predict the risk of coronary artery disease. The study found that the new cardiometabolic ratios remained significant as independent variables after multivariate adjustment, providing optimal discriminating cutoffs for CAD. Substituting PON1 activity for HDL-C in atherogenic lipid ratios can enhance CAD risk assessment by providing an index of HDL activity.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Sin Eng Chia, Lim John Wah, Judy Sng Gek Khim, Joanne Yoong, Raymond Boon Tar Lim, Chia Kee Seng
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2015)
Article
Endocrinology & Metabolism
Yonghai Lu, Chong Huang, Liang Gao, Yong-Jiang Xu, Sin Eng Chia, Shengsen Chen, Ning Li, Kangkang Yu, Qingxia Ling, Qi Cheng, Mengqi Zhu, Mingquan Chen, Choon Nam Ong
Article
Medicine, General & Internal
See Ming Lim, Sin Eng Chia
SINGAPORE MEDICAL JOURNAL
(2015)
Article
Environmental Sciences
Na Pi, Sin Eng Chia, Choon Nam Ong, Barry C. Kelly
Article
Chemistry, Analytical
Bee Lan Lee, Her Yam Ong, Sin Eng Chia, Choon Nam Ong
ANALYTICAL METHODS
(2011)
Article
Oncology
Sin-Eng Chia, Kin-Yoke Wong, Christopher Cheng, Weber Lau, Puay-Hoon Tan
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
(2012)
Article
Public, Environmental & Occupational Health
Brian See, Marcus Tan, Sin Eng Chia, Wee Hoe Gan, Robin Low, Gerard Nah
AVIATION SPACE AND ENVIRONMENTAL MEDICINE
(2014)
Article
Oncology
Cynthia Chen, Nasheen Naidoo, Qian Yang, Mikael Hartman, Helena M. Verkooijen, En Yun Loy, Christine Bouchardy, Kee Seng Chia, Sin Eng Chia
Article
Oncology
Kin-Yoke Wong, Bee-Choo Tai, Sin-Eng Chia, Ponnudurai Kuperan, Khai-Mun Lee, Soon-Thye Lim, Susan Loong, Benjamin Mow, Siok-Bian Ng, Leonard Tan, Soo-Yong Tan, Suat-Hoon Tan, Miriam Tao, Alvin Wong, Gee-Chuan Wong, Adeline Seow
CANCER CAUSES & CONTROL
(2012)
Article
Public, Environmental & Occupational Health
S. E. Chia, K. Y. Wong, B. C. Tai
OCCUPATIONAL MEDICINE-OXFORD
(2012)
Article
Oncology
C. Chong, L. Fong, R. Lai, W. K. O. Lau, M. Hartmann, S. E. Chia
PROSTATE CANCER AND PROSTATIC DISEASES
(2012)
Correction
Oncology
C. Chong, L. Fong, R. Lai, Y. T. Koh, W. K. O. Lau, M. Hartmann, S. E. Chia
PROSTATE CANCER AND PROSTATIC DISEASES
(2012)
Article
Oncology
Jason Yongsheng Chan, Huihua Li, Onkar Singh, Anupama Mahajan, Saminathan Ramasamy, Koilan Subramaniyan, Ravindran Kanesvaran, Hong Gee Sim, Tsung Wen Chong, Yik-Ying Teo, Sin Eng Chia, Min-Han Tan, Balram Chowbay
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2013)
Article
Medicine, General & Internal
Lucy Leong, Sin Eng Chia
SINGAPORE MEDICAL JOURNAL
(2012)
Article
Medicine, General & Internal
Sin Eng Chia, Chuen Seng Tan, Gek Hsiang Lim, Xueling Sim, Weber Lau, Kee Seng Chia
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2010)