Article
Plant Sciences
Antonis Ververis, Kristia Ioannou, Sotiris Kyriakou, Niki Violaki, Mihalis I. Panayiotidis, Michael Plioukas, Kyproula Christodoulou
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative condition in aging populations with no effective therapy available. Recent research has focused on reducing the toxic amyloid beta aggregates and oxidative stress, which are closely associated with AD. Medicinal plants, such as Sideritis scardica (SS), have shown neuroprotective effects against AD. We investigated the antioxidant and neuroprotective potential of eight solvent fractions derived from SS and found that most fractions were rich in phenolics and flavonoids, with significant antioxidant activity. Four SS extracts were able to partially restore cell viability in A beta(25-35)-treated neuroblastoma cells, indicating their neuroprotective properties. These extracts contained neuroprotective substances like apigenin, myricetin-3-galactoside, and ellagic acid. The findings suggest that specific SS mixtures have potential for the development of herbal drugs and functional food products to alleviate AD symptoms.
Article
Nutrition & Dietetics
Won Seok Lee, Hae-June Lee, Ji Yeong Yang, Hye-Lim Shin, Sik-Won Choi, Jong-Ki Kim, Woo Duck Seo, Eun Ho Kim
Summary: Oat seedling extract (OSE) has been found to have antioxidant activity and a specific mechanism for combating Alzheimer's disease (AD), providing neuroprotective effects against neurodegeneration, synaptic dysfunction, and neuroinflammation.
Article
Pharmacology & Pharmacy
Nianxin Kang, Yage Luan, Yu Jiang, Wenhao Cheng, Yongjian Liu, Zhijun Su, Yonggang Liu, Peng Tan
Summary: This study demonstrated the neuroprotective effects of oligosaccharides in Rehmanniae Radix on Alzheimer's disease using a Caenorhabditis elegans model. The oligosaccharides improved learning and memory, prolonged lifespan, and reduced paralysis in C. elegans. Furthermore, they alleviated Aβ-induced toxicity through antioxidant activity and inhibition of Aβ aggregation. The expression of related genes was also modulated, enhancing the resistance to oxidative stress and Aβ toxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yi Wang, Kaiyue Wang, Junyuan Yan, Qian Zhou, Xiaoying Wang
Summary: Alzheimer's disease is an incurable type of dementia in the elderly, and our understanding of its etiology and pathogenesis is limited. However, several hypotheses related to risk factors have been proposed, and plant-derived dietary polyphenols have been shown to have protective effects against neurodegenerative diseases. This review summarizes the regulatory effects of these polyphenols on AD-related molecular mechanisms and discusses the issue of bioavailability and potential improvements, aiming to encourage further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Srijan Shrestha, Jae Sue Choi, Wei Zhang, Scott D. Smid
Summary: Phlorotannins exhibit neuroprotective activity against oxidative stress and amyloid beta exposure, with fucofuroeckol-type phlorotannins showing broader neuroprotective effects.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Cell Biology
Xin Chen, Joshua Drew, Wren Berney, Wei Lei
Summary: Natural products have attracted interest in the research community and pharmaceutical industry for their neuroprotective activity against Alzheimer's disease (AD). They target different pathological mechanisms associated with AD and their mixtures or extracts containing multiple bioactive compounds may exhibit multiple neuroprotective mechanisms, offering a potential approach for AD drug discovery.
Article
Biochemistry & Molecular Biology
Shagufta Parveen, Aneeqa Batool, Nusrat Shafiq, Maryam Rashid, Ayesha Sultan, Gezahign Fentahun Wondmie, Yousef A. Bin Jardan, Simone Brogi, Mohammed Bourhia
Summary: In this study, compounds with antioxidant activity were screened from pomegranate peels for the treatment of Alzheimer's disease. The inhibitory effect of estrogen on Alzheimer's disease and its role in protecting the brain were investigated. Computational calculations and experiments identified hesperidin as a potential candidate for drug discovery.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dang Diem Hong, Le Thi Thom, Nguyen Cam Ha, Ngo Thi Hoai Thu, Hoang Thi Minh Hien, Luu Thi Tam, Nguyen Manh Dat, Tran Mai Duc, Nguyen Van Tru, Nguyen Thi Minh Hang, Ranga Rao Ambati
Summary: Fucoxanthin extracted from Vietnamese S. oligocystum exhibits AChE inhibitory and antioxidant activities. It provides neuroprotection against amyloid beta-protein fragment-induced neurotoxicity in C6 cells. The neuroprotective effect of fucoxanthin is mediated by regulation of antioxidant enzyme and signaling pathway gene expression.
Review
Neurosciences
Yee Jie Yeap, Nagaendran Kandiah, Dean Nizetic, Kah-Leong Lim
Summary: Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of elderly individuals worldwide. Despite extensive research, the cause of AD remains controversial and there is currently no cure. However, recent studies have identified the protease BACE2 as a potential therapeutic target for AD due to its non-amyloidogenic role in preventing the generation of toxic amyloid-beta peptides. This review discusses emerging evidence supporting the neuroprotective role of BACE2 in AD and provides an update on the identification of gene mutations linked to increased risk and earlier disease onset.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Chemistry, Medicinal
Li-Cheng Zhou, Ying-Fan Liang, Yi Huang, Gui-Xiang Yang, Lu-Lu Zheng, Jia-Min Sun, Yang Li, Fu-Li Zhu, He-Wen Qian, Rui Wang, Lei Ma
Summary: The study developed diosgenin-indole compounds with potential neuroprotective effects against H2O2, 6-OHDA, and Aβ damages. Compound 5b showed promising results with strong binding affinity to Aβ(1-42), favorable BBB permeation, and absorption abilities. In vivo experiments demonstrated that 5b attenuated memory and learning impairments of Aβ-injected mice, suggesting its potential as a dual-functional neuroprotective agent against AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Megan J. J. Lantz, Alyssa M. M. Roberts, Donovan D. D. Delgado, Robert A. A. Nichols
Summary: Alzheimer's disease is characterized by the accumulation of amyloid beta (Aβ) and neurofibrillary tangles, leading to chronic neuroinflammation. The N-terminal Aβ fragment and N-Aβ core have been shown to protect against neurodegeneration. This study provides evidence that these fragments can also alleviate persistent neuroinflammation in Alzheimer's disease.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Pharmacology & Pharmacy
Youn Young Lee, Jong In Han, Kyung Eun Lee, Sooyoung Cho, Eun Cheng Suh
Summary: Alzheimer's disease is a common neurodegenerative disease associated with pathological autophagy-lysosomal pathway dysfunction. Dexmedetomidine has been suggested as an adjuvant to general anesthesia, with advantages in reducing postoperative cognitive dysfunction. However, there is limited evidence on the effects of Dex on neuronal autophagy dysfunction in Alzheimer's disease models.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Elizaveta A. Dutysheva, Irina A. Utepova, Maria A. Trestsova, Alexander S. Anisimov, Valery N. Charushin, Oleg N. Chupakhin, Boris A. Margulis, Irina Guzhova, Vladimir F. Lazarev
Summary: Chemicals that induce the synthesis of heat shock proteins have been shown to improve neuronal survival and provide neuroprotective effects in the pathogenesis of Alzheimer's disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Plaipol Dedvisitsakul, Kanchana Watla-iad
Summary: This study evaluated the potential of some Thai edible plants in terms of their antioxidant activity and inhibitory effects on diabetic complications. The results showed that Caesalpinia mimosoides and Glochidion hirsutum had the highest phenolic and flavonoid content, respectively, while Schinus terebinthifolius had the highest antioxidant activity. Basella alba and S. terebinthifolius exhibited the strongest inhibitory activities against alpha-amylase and alpha-glycosidase, respectively. The extracts of Glochidion hirsutum and Polygonum odoratum showed stronger inhibitory effects on AGEs formation from glucose compared to the common drug aminoguanidine. The selected extracts in this study demonstrated their potential applications for the prevention of diabetes and its complications through the inhibitory effects on alpha-amylase, alpha-glycosidase, AGEs formation, and oxidative stress.
Article
Agricultural Engineering
Jingmo Zhou, Shubin Wu, Ying Liu
Summary: Expenditure isolation of lignin and the understanding of its structural variations during different isolation processes are crucial for the high-value utilization of lignin. This study proposed a green deep eutectic solvent (DES) consisting of choline chloride, ethylene glycol, and 4-chlorobenzene sulfonic acid for rapid lignin separation from poplar. The structural variations of DES lignin and its relationship with alkali pre-extraction of hemicellulose were investigated. The results showed that alkali pretreatment enhanced the DES separation of lignin and promoted the cleavage of specific linkages, resulting in reduced molecular weight and thermal stability of isolated DES lignin. Moreover, DES lignin obtained from integrated utilization displayed higher purity and S/G ratio compared to lignin obtained from direct DES treatment.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yuping Li, Ziyan Xie, Yun Huang, Jiangyi Zeng, Chao Yang, Ling Yuan, Ying Wang, Yongqing Li
Summary: In this study, the characteristic flavonoids (CFs) of three licorice species were identified through integrated metabolic and transcriptomic analysis. The key regulators of CF biosynthesis were also identified. These findings provide valuable information for understanding the biosynthesis of CFs and future breeding of Glycyrrhiza varieties.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xianjie Pan, Zhaoyi Luo, Fanqi Liu, Quanqian Yi, Yanning Zeng
Summary: This study presents a novel strategy for fabricating fully bio-based epoxy vitrimers using peach gum and itaconic acid, which exhibit superior mechanical properties and thermostability. The materials were characterized and the self-healing and recycling capabilities were evaluated. The results demonstrate the potential of using these materials for sustainable industrial applications.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Mohsen Sabzi-Nojadeh, Mohammad Pouresmaeil, Mina Amani, Mehdi Younessi-Hamzekhanlu, Filippo Maggi
Summary: This study shows that inoculating Summer savory plants with endophytic fungus Trichoderma harzianum can improve plant growth and increase salt tolerance. The fungus enhances growth, restores chlorophyll and antioxidant levels, reduces harmful substances, and increases proline and soluble sugar levels, thereby increasing crop productivity in saline conditions.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yu Liu, Lei Li, Aichen Zhao, Xiuming Song, Lulu Wei, Mengdi Fang, Chuchu Zheng, Xiaodong Zhu
Summary: This study investigates the impact of peppermint essential oil microcapsules on the unpleasant odor emissions from wax oil coated wood products. The results show that microcapsules can improve the time and stability of odor release.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Mesut Budak, Mirac Kilic, Hikmet Guenal, Ismail Velik, Mesut Sirri
Summary: This study assessed land suitability for rapeseed production using topography, climate, and soil data by analytical hierarchy process (AHP) and the Mamdani Fuzzy Inference System (MFIS). The study area covered land in the Diyarbakir province of southeastern Turkiye. The results indicated the proportions of different land suitability classes and showed the compatibility of AHP and MFIS methods in assessing suitability.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Rui Tian, Yue Liu, Chao Wang, Weikun Jiang, Srinivas Janaswamy, Guihua Yang, Xingxiang Ji, Gaojin Lyu
Summary: In this study, hollow and solid lignin nanoparticles were synthesized through self-assembly and their application in PVA nanocomposite films was investigated. The results showed that the presence of hollow lignin nanoparticles in the films resulted in a room-like network structure, while the solid lignin nanoparticles induced different structural changes. The inclusion of LNPs improved the mechanical properties of the films, and both types of LNPs exhibited good hydrophobicity.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Marcos Vinicius Silva de Andrade, Simone Ribeiro Lucho, Renato Delmondez de Castro, Paulo Roberto Ribeiro
Summary: Stevia rebaudiana Bertoni, commonly known as stevia, is a widely cultivated shrub with highly sweetening metabolites. It has gained significant interest in the food and beverage industries due to its extremely sweet taste and various health benefits. Researchers are currently focused on studying biotechnological strategies to enhance the biosynthesis of stevia plant metabolites for improved cultivation and production.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Eleonora Cintura, Paulina Faria, Luisa Molari, Luca Barbaresi, Dario D'Orazio, Lina Nunes
Summary: This study investigated the properties of Arundo donax as a building material and found that it has strong adaptability, high hygroscopicity, and unique sound absorption behavior. The mechanical tests also demonstrated the applicability of the Arundo donax-based composite. This opens up new possibilities for the further application of Arundo donax-based materials.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Stiina Kotiranta, Juha-Matti Pihlava, Titta Kotilainen, Pauliina Palonen
Summary: The effect of light spectra, particularly far-red and short wavelength radiation, on the growth and secondary metabolites of cannabis is significant. Altering the R:FR ratio can increase the concentration and yield of secondary metabolites, while short wavelength radiation does not significantly affect plant morphology and secondary metabolite concentrations.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xuze Liu, Fangmin Liang, Jinyuan Cheng, Xuelian Zhou, Jia Wang, Guigan Fang, Kuizhong Shen, Xianzhi Meng, Chen Huang, Arthur J. Ragauskas
Summary: A novel Na2S-facilitated DES pretreatment method was proposed to fractionate moso bamboo, which achieved high lignin removal and preserved most cellulose and hemicellulose with excellent enzymatic digestibility.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Zechun Ren, Xinyuan Zhou, Kejiao Ding, Tong Ji, Hao Sun, Xiang Chi, Yunzhao Wei, Min Xu
Summary: This study prepared a thermal/magnetic/light-triggered multi-stimuli responsive shape memory polymer composite with excellent properties by adding magnetic nanoparticles into a polyurethane composite. The composite showed high shape recovery rate, fast response behavior, and suitability for 3D printing. Controllable external stimuli allowed for dynamic, remote, and precise control of 4D transformations. This work is significant for the design of smart materials and devices.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Yurany Camacho Ardila, Jaiver Efren Jaimes Figueroa, Maria Regina Wolf Maciel
Summary: The higher heating value (HHV) and elemental composition are important properties of biomass, and their prediction using proximate and ultimate analysis is accurate.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Xiaohan Chen, Xianke Wang, Lili Shang, Xinxin Ma, Changhua Fang, Benhua Fei, Huanrong Liu, Shuqin Zhang
Summary: This study focuses on the comprehensive characterization of the three-dimensional (3D) structure of bamboo parenchyma and the evaluation of its tensile and compressive properties, as well as the analysis of its failure mechanisms. The study found that the measured tensile strength and elastic modulus of the parenchyma tissue are 48.81 MPa and 706.48 MPa, respectively. Compression failure modes in parenchyma tissue encompass compression bending and cell fracture, shear failure of the middle lamella, and detachment and debonding of the cell wall.
INDUSTRIAL CROPS AND PRODUCTS
(2024)
Article
Agricultural Engineering
Tianfeng Liu, Yuxin Liu, Yunlin Fu, Mengji Qiao, Penglian Wei, Zhigao Liu, Yingjian Li
Summary: This study explored the formation mechanism of agarwood induced by fungus and its potential application in high-quality and high-yielding agarwood production. The results showed that the transition layer played a critical role in the continuous accumulation of agarwood, and the parenchyma cells of the xylem rays and interxylary phloem were the main action site of fungus. The accumulation and distribution of chemical composition in different layers were also investigated. The study identified the drivers of specific compounds and provided a theoretical foundation for future agarwood production.
INDUSTRIAL CROPS AND PRODUCTS
(2024)