Article
Genetics & Heredity
Fabian Berg, Dirk A. Moser, Verena Hagena, Fabian Streit, Benjamin Mosch, Robert Kumsta, Stephan Herpertz, Martin Diers
Summary: MicroRNAs are short RNAs that are expressed in specific tissues and regulate gene expression post-transcriptionally. In this study, DNA variations in microRNA genes and their regulatory regions, as well as in protein-coding genes, were investigated in relation to fibromyalgia. The results suggest that two microRNA-related polymorphisms may have a functional role in the pathogenesis of fibromyalgia.
Article
Medicine, General & Internal
Golnaz Barjandi, Eva Kosek, Britt Hedenberg-Magnusson, Ana Miriam Velly, Malin Ernberg
Summary: The study found that patients with MFP and FM were more similar in comorbidity, and should be differentiated from MYA in clinical settings and pain management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Evguenia Nepotchatykh, Iurie Caraus, Wesam Elremaly, Corinne Leveau, Mohamed Elbakry, Christian Godbout, Bita Rostami-Afshari, Diana Petre, Nasrin Khatami, Anita Franco, Alain Moreau
Summary: This study investigates the differential expression profiles of 11 circulating miRNAs associated with ME/CFS pathogenesis in FM patients and those with a comorbid diagnosis of FM associated with ME/CFS. The study reveals differential miRNA expression between ME/CFS, FM, and ME/CFS + FM, which correlate to symptom severity. A machine-learning model based on the levels of these miRNAs is provided for discriminating between ME/CFS, FM, and ME/CFS + FM. The study suggests these miRNAs as potential biomarkers for distinguishing ME/CFS from FM, highlighting the importance of proper diagnosis for elucidating the pathophysiology and establishing effective treatments for both diseases.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Menghui Yao, Shuolin Wang, Yingdong Han, He Zhao, Yue Yin, Yun Zhang, Xuejun Zeng
Summary: This study investigated the differences in clinical features and pathophysiology of fibromyalgia (FM) patients under different inflammatory status. Micro-inflammation status in FM was found to be significantly associated with major depression, higher BMI, activated dendritic cells, and neutrophils. Functional enrichment analysis showed that innate immune response and antibacterial response were significantly enriched in the micro-inflammation subtype. A reliable classifier based on five hub differentially expressed inflammatory genes and two clinical parameters was constructed using a support vector machine model.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Edurne Ubeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia Maria Gallego-Sendarrubias, Cesar Fernandez-de-Las-Penas, Jose Luis Arias-Buria, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study found a good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of the condition and hence provide synergistic information.
Review
Biochemistry & Molecular Biology
Michael Gyorfi, Adam Rupp, Alaa Abd-Elsayed
Summary: This article examines the biological, genetic, and environmental factors that may impact the pathogenesis of fibromyalgia. It discusses abnormalities in pain inhibition, changes in sensory input processing, genetics, exposure to stressors, and abnormal reactions in the autonomic nervous system. The article concludes that further research will improve our understanding of the pathophysiology of fibromyalgia and lead to better treatment options for patients.
Review
Biochemistry & Molecular Biology
Matic Broz, Anja Kolaric, Marko Jukic, Urban Bren
Summary: NRP1, one of the homologous neuropilins found in vertebrates, acts as a receptor for various ligands and is associated with both physiological and pathological conditions. Its recent discovery as a coreceptor for SARS-CoV-2 has shifted focus to COVID-19 research, while its involvement in diseases like cancer and neuropathic pain remains significant. NRP1 modulators, including peptidomimetics and small molecule antagonists, offer potential therapeutic opportunities for NRP1-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Luisa P. Janssen, Liciane F. Medeiros, Andressa De Souza, Juliana Da Silva
Summary: The review identifies multiple genes associated with the pathophysiology and genetic influence of fibromyalgia, with some polymorphisms linked to susceptibility to the condition. These genes are also connected to psychological disorders, pain sensitivity, migraine, and other related illnesses.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2021)
Article
Multidisciplinary Sciences
Johannes J. Rasker, Frederick Wolfe, Ewa G. Klaver-Krol, Machiel J. Zwarts, Peter M. ten Klooster
Summary: The study investigated the association between fibromyalgia and self-reported seizures in rheumatoid arthritis patients. Results showed a significant link between FM diagnostic variables, FM-related symptoms, and self-reported seizures, indicating a complex relationship between multi-symptom comorbidity and seizures. Future studies are needed to confirm these findings using validated FM criteria assessments and clinically verified diagnoses of epileptic and psychogenic seizures.
Article
Biochemistry & Molecular Biology
Siyu Yao, Haona Bao, Shreya Madhav Nuguri, Lianbo Yu, Zhanna Mikulik, Michelle M. Osuna-Diaz, Katherine R. Sebastian, Kevin V. Hackshaw, Luis Rodriguez-Saona
Summary: This study aimed to develop a rapid diagnostic method for fibromyalgia syndrome (FM) and related rheumatologic disorders using portable FT-IR techniques. Blood samples from FM patients and patients with related disorders were collected and analyzed. The results showed that vibrational spectra could accurately distinguish FM and related diseases, providing potential biomarkers. This research evaluated the feasibility of portable FT-IR combined with chemometrics as a high-throughput tool for diagnosing FM in real-time.
Article
Chemistry, Organic
Tanmay Chatterjee, Brindaban C. Ranu
Summary: Ball-milling has gained significant attention as a green tool for conducting challenging organic transformations under transition-metal-free and solvent-free conditions in recent decades. This method allows the synthesis of organosulfur and related heterocycles from readily available starting materials without the use of hazardous chemicals or solvents. The development of green strategies in ball-milling conditions for the synthesis of organosulfur and related heterocycles has been highlighted in this synopsis.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Clinical Neurology
Felix Angst, Thomas Benz, Susanne Lehmann, Peter Sandor, Stephan Wagner
Summary: The study compared the characteristics and health status of patients with fibromyalgia and lipedema, revealing differences in age, BMI, and overall health compared to population norms for both conditions. Fibromyalgia showed more pronounced disease perception and impaired health compared to lipedema.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Thomas Weber, Eva Tatzl, Karl Kashofer, Magdalena Holter, Slave Trajanoski, Andrea Berghold, Akos Heinemann, Peter Holzer, Michael Karl Herbert
Summary: Fibromyalgia-syndrome (FMS) is a complex disease characterized by chronic widespread pain and additional symptoms. This study found that FMS patients differed from healthy controls in terms of pain parameters and psychological disturbances, but not in the composition and diversity of the fecal microbiome. The contribution of the gut microbiome to the pathophysiology of FMS was considered limited.
Article
Nursing
Alma Rus, Inmaculada Robles-Fernandez, Luis Javier Martinez-Gonzalez, Ramon Carmona, Maria Jesus Alvarez-Cubero
Summary: This study explored SNPs in genes related to oxidative stress in fibromyalgia (FM) patients and healthy controls, revealing associations between SOD1 and CYBA variants with clinical manifestations of FM. The findings offer new insights into the pathogenesis of FM, potentially guiding future research on the syndrome's causes.
Article
Anesthesiology
Orman Trent Hall, Julie Teater, Parker Entrup, Megan Deaner, Craig Bryan, Steven E. E. Harte, Chelsea M. M. Kaplan, Kihn Luan Phan, Daniel J. J. Clauw
Summary: This study used the ACR-FMS questionnaire to investigate the association between fibromyalgia and pain-related exacerbation of OUD. The results showed that participants with fibromyalgia were more likely to experience pain-related OUD exacerbations. Additionally, a new scale was introduced to measure pain-related OUD exacerbation, which was found to have good psychometric properties.
Article
Orthopedics
David J. Kohns, Ryan Scott, Joel Castellanos, Darin Scribner, Ryan Hodges, Daniel J. Clauw
Summary: The degree of nociplastic pain in patients with myofascial pain is inversely related to improvements from physical therapy. Patients with moderate to higher levels of nociplastic pain are less likely to have clinically significant improvements, but still benefit from physical therapy.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2022)
Article
Rheumatology
Meriah N. Moore, Beth Wallace, Jing Song, Lutfiyya N. Muhammad, Andrew C. Heisler, Daniel J. Clauw, Marcy B. Bolster, Wendy Marder, Tuhina Neogi, Alyssa Wohlfahrt, Dorothy D. Dunlop, Yvonne C. Lee
Summary: This study aimed to examine the correlation between the self-administered Fibromyalgia Survey Questionnaire (FSQ) and quantitative sensory testing (QST) in patients with rheumatoid arthritis (RA). The results showed a weak correlation between FSQ and QST, indicating that the two measures cannot be used interchangeably.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Jing Song, Lutfiyya N. Muhammad, Tuhina Neogi, Dorothy D. Dunlop, Alyssa Wohlfahrt, Marcy B. Bolster, Clifton O. Bingham, Daniel J. Clauw, Wendy Marder, Yvonne C. Lee
Summary: This study examined the relationship between pain sensitization and sleep disturbances in patients with rheumatoid arthritis (RA) using quantitative sensory testing (QST). The results showed a correlation between sleep disturbances and pain sensitization, suggesting that pain sensitization may be one mechanism through which sleep disturbances contribute to pain.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Giovanni Berardi, Laura Frey-Law, Kathleen A. Sluka, Emine O. Bayman, Christopher S. Coffey, Dixie Ecklund, Carol G. T. Vance, Dana L. Dailey, John Burns, Asokumar Buvanendran, Robert J. McCarthy, Joshua Jacobs, Xiaohong Joe Zhou, Richard Wixson, Tessa Balach, Chad M. Brummett, Daniel Clauw, Douglas Colquhoun, Steven E. Harte, Richard E. Harris, David A. Williams, Andrew C. Chang, Jennifer Waljee, Kathleen M. Fisch, Kristen Jepsen, Louise C. Laurent, Michael Olivier, Carl D. Langefeld, Timothy D. Howard, Oliver Fiehn, Jon M. Jacobs, Panshak Dakup, Wei-Jun Qian, Adam C. Swensen, Anna Lokshin, Martin Lindquist, Brian S. Caffo, Ciprian Crainiceanu, Scott Zeger, Ari Kahn, Tor Wager, Margaret Taub, James Ford, Stephani P. Sutherland, Laura D. Wandner
Summary: Chronic pain is a global health problem that reduces quality of life, but its clinical management has been hindered by incomplete understanding of risk factors and molecular mechanisms. The A2CPS Program aims to predict chronic pain development following surgery using biomarkers. This study collects standardized data from multiple clinical sites to advance understanding of the transition from acute to chronic postsurgical pain.
FRONTIERS IN MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper
Summary: Chronic pain is common in patients with cirrhosis and has a negative impact on their health-related quality of life and functional status. However, there is limited guidance on appropriate pain management in this population and pharmacologic treatment may lead to harmful outcomes. By categorizing chronic pain into different mechanistic types and discussing the identification, etiology, and treatment of these types, including nonpharmacologic therapies, we provide a framework for tailoring treatments to the specific challenges faced by patients with cirrhosis.
Article
Rehabilitation
Kosaku Aoyagi, Jianghua He, Daniel J. Clauw, Neena K. Sharma
Summary: The study found that sleep quality was poorer in individuals with chronic low back pain (CLBP) who exhibited signs of central sensitization (CS). Clinicians can consider using the 2011 Fibromyalgia Survey (2011 FM survey) to identify patients with both CS and sleep problems.
PHYSIOTHERAPY RESEARCH INTERNATIONAL
(2022)
Article
Rheumatology
Jason S. Kim, Silvana Borges, Daniel J. Clauw, Philip G. Conaghan, David T. Felson, Thomas R. Fleming, Rachel Glaser, Elizabeth Hart, Marc Hochberg, Yura Kim, Virginia B. Kraus, Larissa Lapteva, Xiaojuan Li, Sharmila Majumdar, Timothy E. McAlindon, Ali Mobasheri, Tuhina Neogi, Frank W. Roemer, Rebecca Rothwell, Robert Shibuya, Jeffrey Siegel, Lee S. Simon, Kurt P. Spindler, Nikolay P. Nikolov
Summary: This article summarizes a workshop on osteoarthritis, discussing the current state of science, identifying knowledge gaps, and examining developmental and regulatory challenges in bringing these products to market.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Clinical Neurology
Sara R. Till, Andrew Schrepf, Daniel J. Clauw, Steven E. Harte, David A. Williams, Sawsan As-Sanie
Summary: This study explores the relationship between nociplastic pain and the severity and impact of pelvic pain symptoms. The results suggest that the degree of nociplastic pain is associated with increased severity, frequency, interference, and pelvic myofascial pain of pelvic pain.
Letter
Anesthesiology
Michael H. Kaplan, Celine H. Zhou, Emily Carroll, Alan D. Weinberg, Daniel J. Clauw, Trung Thanh Ngo, Ioannis Tassiulas
Article
Medicine, General & Internal
Bhaavna Yalavarthi, Johari Summerville, Nikki Farahani, Lillian Z. Xiao, Christine Yu, Deena Aboul-Hassan, Sia Rajgarhia, Daniel J. Clauw, J. Michelle Kahlenberg, Melissa Dejonckheere, Rachel S. Bergmans
Summary: This qualitative study focused on the experiences of Black adults with SLE in Michigan, identifying opportunities for improving care based on their perspectives. Four main themes were identified: awareness of SLE signs and symptoms, patient-clinician interactions, medication adherence and health effects, and comprehensive care plans. Participants emphasized the importance of behavioral change in disease management and the negative impact of social risk factors.
Article
Cardiac & Cardiovascular Systems
Hamid Ghanbari, Daniel Whibley, H. Immo Lehmann, Zhi Li, Anna Kratz, Daniel J. Clauw, Brahmajee K. Nallamothu
Summary: This study aimed to determine the strength of temporal association between atrial fibrillation (AF) episodes and symptoms. The data showed that AF episodes 15 minutes prior to symptom reporting were more likely to be associated with worse symptoms. The correlation between symptom severity and AF diminished as time interval increased.
CARDIOVASCULAR DIGITAL HEALTH JOURNAL
(2023)
Article
Rheumatology
Johari Summerville, Nikki Farahani, Bhaavna Yalavarthi, Deena Aboul-Hassan, Sia Rajgarhia, Lillian Z. Xiao, Christine Yu, Daniel J. Clauw, Joanne M. Kahlenberg, Melissa Dejonckheere, Rachel S. Bergmans
Summary: This study aimed to identify practical recommendations for increasing the engagement and inclusion of Black adults in systemic lupus erythematosus (SLE) research. Through semi-structured interviews with 30 Black adults diagnosed with SLE in Michigan, the study identified factors influencing research perceptions and areas where research falls short in meeting participant needs and expectations. The findings highlight the importance of centering the perspectives of Black individuals with SLE throughout the research process, beyond simply ensuring racial diversity among study participants.
Article
Anesthesiology
Chelsea M. Kaplan, Andrew Schrepf, Kevin F. Boehnke, Ying He, Tristin Smith, David A. Williams, Rachel Bergmans, Terri Voepel-Lewis, Afton L. Hassett, Richard E. Harris, Daniel J. Clauw, Adriene M. Beltz, Steven E. Harte
Summary: Identifying symptom-based risk factors for multisite pain in children is critical for early prevention. Somatic awareness, sleep and attention problems represent actionable targets for early detection, treatment, and possible prevention of multisite pain in youth.
CLINICAL JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Emily Foxen-Craft, Elizaveta Bourchtein, Chelsea Kaplan, Daniel J. Clauw, Eric Scott
Summary: This study aimed to compare whether primary pain location or pain widespreadedness is more informative for pain-related symptoms in pediatric chronic pain. The results showed that pain widespreadedness was more consistently associated with pain-related outcomes among pediatric chronic pain patients than primary pain location.
CLINICAL JOURNAL OF PAIN
(2023)
Meeting Abstract
Rheumatology
Flavia Sunzini, Kristian Stefanov, Salim Al-Wasity, Steven E. Harte, Richard E. Harris, Daniel J. Clauw, Stefan Siebert, Carl Goodyear, Gordon Waiter, Neil Basu
ARTHRITIS & RHEUMATOLOGY
(2022)