Article
Environmental Sciences
Genoa R. Warner, Diana C. Pacyga, Rita S. Strakovsky, Rebecca Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: The study revealed associations between phthalates and hot flashes in midlife women, suggesting a potential impact on hot flash risk. Factors such as menopause status, BMI, race/ethnicity, and depressive symptoms may influence these associations.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Ryan S. Babadi, Paige L. Williams, Zhong Li, Rebecca L. Smith, Rita S. Strakovsky, Russ Hauser, Jodi A. Flaws, Tamarra James-Todd
Summary: This study examines the associations between urinary phthalate metabolite concentrations and hot flash outcomes in midlife women. The results suggest that phthalate metabolites are associated with certain hot flash outcomes, indicating that midlife may be a sensitive period for higher phthalate metabolite concentrations and menopausal symptoms.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Mabel Toribio, Evelynne S. Fulda, Sarah M. Chu, Zsofia D. Drobni, Magid Awadalla, Madeline Cetlin, Takara L. Stanley, Crystal M. North, Michael D. Nelson, Michael Jerosch-Herold, Lidia S. Szczepaniak, Tricia H. Burdo, Sara E. Looby, Tomas G. Neilan, Markella Zanni
Summary: Women with HIV transitioning through menopause have increased cardiovascular disease risk, with higher hot flash burden related to select CVD risk indices in this population.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Review
Obstetrics & Gynecology
Sarah Witkowski, Rose Evard, Jacquelyn J. Rickson, Quinn White, Lynnette Leidy Sievert
Summary: This review summarizes the scientific evidence regarding the effect of physical activity and exercise on hot flashes (HFs) in menopausal women. The majority of randomized control trials suggest that aerobic and resistance exercise can decrease subjectively experienced HFs. Some studies also suggest that rhythmic exercise may be beneficial for reducing HF symptoms, but further research is needed.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Obstetrics & Gynecology
Zaher Merhi, Serin Seckin, Marco Mouanness
Summary: This case report presents a patient with very low ovarian reserve who inadvertently reported significant improvement in menopausal symptoms, including hot flashes, for 14 weeks following intra-ovarian PRP injection. The findings suggest that PRP may serve as a potential alternative therapy for hot flashes in women with contraindications for hormone replacement therapy.
REPRODUCTIVE SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Su-Ji Choi, Dong-Il Kim, Sang Ho Yoon, Chang -Min Choi, Jeong-Eun Yoo
Summary: This study found that pharmacopuncture with PLC did not significantly differ from normal saline in reducing hot flash scores for perimenopausal and postmenopausal women. While the therapy appeared safe, further research is needed to assess the long-term effects of PLC extract in a large randomized controlled trial.
INTEGRATIVE MEDICINE RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Hana Kahleova, Danielle N. Holtz, Noah Strom, Alex La Reau, Sinjana Kolipaka, Natalie Schmidt, Ellen Hata, Tatiana Znayenko-Miller, Richard Holubkov, Neal D. Barnard
Summary: This study investigated the role of gut microbiome changes in mediating the effects of a dietary intervention on postmenopausal vasomotor symptoms. The results showed that changes in the gut microbiome were associated with a significant reduction in both frequency and severity of hot flashes. However, further clinical trials are needed to validate these findings.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Article
Endocrinology & Metabolism
Elizabeth A. McCarthy, Daniel Dischino, Caroline Maguire, Silvia Leon, Rajae Talbi, Eugene Cheung, Claudio D. Schteingart, Pierre J. M. Riviere, Susan D. Reed, Robert A. Steiner, Victor M. Navarro
Summary: The activation of kappa receptors to inhibit kisspeptin neuronal activity shows potential as a novel therapeutic approach for treating VMS and PCOS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Medicine, General & Internal
Danielle R. Davis, Suchitra Krishnan-Sarin, Carolyn M. Mazure
Summary: This Viewpoint discusses the potential differential impacts of tobacco products on sex and gender subpopulations and suggests that the FDA should formulate regulations in ways that are clinically meaningful.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Maria Tsoumani, Panagiota Efstathia Nikolaou, Aikaterini Argyropoulou, Ioulia Tseti, Sofia Mitakou, Ioanna Andreadou
Summary: The study suggests a novel combination of plant extracts, including Glycyrrhiza glabra, Actaea racemosa, Hypericum perforatum, and Oenothera biennis, to combat hot flashes during menopause. These extracts possess different mechanisms of action, such as estrogen activation, antioxidant effects, and inhibition of the DP1 receptor. The triple combination of these extracts shows efficacy against all three mechanisms and could serve as a multitarget plant-based therapy for the alleviation of hot flashes in postmenopausal women.
Review
Nutrition & Dietetics
Stepan Feduniw, Lidia Korczynska, Konrad Gorski, Magdalena Zgliczynska, Monika Baczkowska, Maciej Byrczak, Jakub Kociuba, Mohamed Ali, Michal Ciebiera
Summary: Menopause is a physiological change in women, but its symptoms can be difficult to accept and hormone therapy may not always be desirable. Vitamin E, as a phytoestrogen, is believed to be useful in alleviating some menopausal symptoms. This review aimed to assess the effectiveness of vitamin E in alleviating menopausal symptoms and found that it influences hot flashes, vascular modulation, lipid profile, and vaginal changes. However, estrogen administration has better clinical effects. Additional high-quality data is needed for conclusive findings.
Article
Nutrition & Dietetics
Lynnette Leidy Sievert, Taniya Sharmeen, Khurshida Begum, Shanthi Muttukrishna, Osul Chowdhury, Gillian R. Bentley
Summary: This study examined the relationship between diet and menopausal symptoms in Bangladeshi women living in Sylhet and London. The findings showed that increased consumption of phytoestrogens and lignans was associated with higher likelihood of hot flashes, while higher consumption of phytoestrogens, lignans, and isoflavones was associated with lower likelihood of vaginal dryness. Night sweats and trouble sleeping were not influenced by phytoestrogen intake.
Article
Multidisciplinary Sciences
Xuechan Yu, Yiming Yu, Hongying Ma, Zhongbo Chen, Zaichun Deng
Summary: There is a significant correlation between smoking and mental activities after dinner, with patients engaging in mental activities after dinner consuming more cigarettes. This study provides evidence that mental activities after dinner are a risk factor for smoking.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Sarah D. Hohl, Richard S. Matulewicz, Ramzi G. Salloum, Jamie S. Ostroff, Timothy B. Baker, Robert Schnoll, Graham Warren, Steven L. Bernstein, Mara Minion, Katie Lenhoff, Neely Dahl, Hee Soon Juon, Ursula Tsosie, Linda Fleisher, Heather D'Angelo, Alex T. Ramsey, Kimlin T. Ashing, Betsy Rolland, Margaret B. Nolan, Jennifer E. Bird, Claire V. T. Nguyen, Danielle Pauk, Robert T. Adsit, Hilary A. Tindle, Kimberly Shoenbill, Sophia Yeung, Cary A. Presant, Kara P. Wiseman, Kuang-Yi Wen, Lou-Anne Chichester, Li-Shiun Chen
Summary: The C3I program found that implementing comprehensive tobacco treatment programs and improving the staff-to-patient ratio can increase the reach of cessation treatment. Strengthening the tobacco treatment team and providing more resources can improve the effectiveness of smoking cessation.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Hana Kahleova, Tatiana Znayenko-Miller, Jaime Uribarri, Natalie Schmidt, Sinjana Kolipaka, Ellen Hata, Danielle N. Holtz, Macy Sutton, Richard Holubkov, Neal D. Barnard
Summary: This study investigated the potential association between modifications to the intake of dietary advanced glycation end-products (AGEs) and the frequency and severity of postmenopausal hot flashes. The study found that adhering to a low-fat vegan diet was significantly associated with a reduction in the frequency and severity of hot flashes in postmenopausal women, independent of changes in energy intake and weight loss.
Article
Obstetrics & Gynecology
Ophelia Yin, Howard A. Zacur, Jodi A. Flaws, Mindy S. Christianson
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2018)
Article
Reproductive Biology
Kadeem A. Richardson, Patrick R. Hannon, Yvette J. Johnson-Walker, Maung Sun Myint, Jodi A. Flaws, Romana A. Nowak
REPRODUCTIVE TOXICOLOGY
(2018)
Article
Clinical Neurology
Rebecca L. Smith, Jodi A. Flaws, Megan M. Mahoney
Article
Toxicology
Radwa Barakat, Po-Ching Lin, Chan Jin Park, Catherine Best-Popescu, Hatem H. Bakry, Mohamed E. Abosalem, Nabila M. Abdelaleem, Jodi A. Flaws, CheMyong Ko
TOXICOLOGICAL SCIENCES
(2018)
Article
Geriatrics & Gerontology
Catheryne Chiang, Lisa Gallicchio, Howard Zacur, Sue Miller, Jodi A. Flaws, Rebecca L. Smith
Article
Reproductive Biology
Chan Jin Park, Radwa Barakat, Alexander Ulanov, Zhong Li, Po-Ching Lin, Karen Chiu, Sherry Zhou, Pablo Perez, Jungyeon Lee, Jodi Flaws, ChemYong Jay Ko
REPRODUCTIVE TOXICOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Andressa Gonsioroski, Vasiliki E. Mourikes, Jodi A. Flaws
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Environmental Sciences
Karen Chiu, Shah Tauseef Bashir, Liying Gao, Jessica Gutierrez, Maria R. C. de Godoy, Jenny Drnevich, Christopher J. Fields, Isaac Cann, Jodi A. Flaws, Romana A. Nowak
Summary: Subacute exposure to DEHP during pregnancy significantly affected the cecal microbiome in pregnant mice, increasing alpha diversity and altering beta diversity. DEHP exposure led to an increase in the relative abundance of Bacteroidetes and a decrease in the relative abundance of Firmicutes and Deferribacteres. In addition, DEHP exposure significantly altered 14 functional pathways, but did not have a significant impact on fertility and birth outcomes.
Article
Environmental Sciences
Karen K. Chiu, Shah Tauseef Bashir, Ahmed M. Abdel-Hamid, Lindsay V. Clark, Mary J. Laws, Isaac Cann, Romana A. Nowak, Jodi A. Flaws
Summary: This study examines the impact of DiNP exposure on the gut microbiota and immune-related factors, revealing that DiNP exposure can alter the composition of the gut microbiota and that the gut contains microbes capable of degrading DiNP.
Article
Environmental Sciences
Diana C. Pacyga, Brad A. Ryva, Romana A. Nowak, Serdar E. Bulun, Ping Yin, Zhong Li, Jodi A. Flaws, Rita S. Strakovsky
Summary: This study investigated the association between phthalates and fibroids and found that each two-fold increase in sigma DEHP or sigma AA was associated with a 13% and 16% greater risk of prior fibroid diagnosis in women. These associations were strongest in women who were overweight/obese and in those diagnosed with fibroids within 5 years before phthalate assessment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Endia J. Fletcher, Ramses Santacruz-Marquez, Vasiliki E. Mourikes, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: This review discusses the effects of phthalate mixtures on the female reproductive system. Phthalates have been found to target the ovaries, disrupting normal reproductive function and potentially affecting folliculogenesis and steroidogenesis. Additionally, phthalates can cross the placental barrier and impact fetal development. However, the specific effects of phthalate mixtures on the ovary and female reproduction are still not well understood.
Review
Biochemistry & Molecular Biology
Nitya Shree, Zehuan Ding, Jodi Flaws, Mahua Choudhury
Summary: The prevalence of poor metabolic health is increasing exponentially worldwide, with exposure to environmental chemicals, such as endocrine-disrupting chemicals (EDCs), gaining attention as a contributing factor. Recent reports suggest that non-coding RNAs, specifically microRNAs (miRs), may play a vital role in this phenomenon.
Review
Environmental Sciences
Xing Zhang, Jodi A. Flaws, Michael J. Spinella, Joseph Irudayaraj
Summary: Endocrine disrupting chemicals (EDCs) are exogenous substances that can alter the endocrine function of an organism, leading to adverse effects on growth, development, metabolism, and reproductive function. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in both animals and humans. This review discusses the renal accumulation of specific EDCs, such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and explores how exposure to these EDCs can result in renal lesions and diseases, including cancer. The regulation of target genes and activation of related pathways by typical EDCs are also summarized.
Article
Environmental Sciences
Vasiliki E. Mourikes, Ramses Santacruz Marquez, Ashley Deviney, Alison M. Neff, Mary J. Laws, Jodi A. Flaws
Summary: Imidacloprid is a neonicotinoid pesticide used in agriculture, gardening, and veterinary medicine. It has the potential to accumulate in the environment and harm non-targeted species. Imidacloprid and its metabolite desnitro-imidacloprid have different effects on follicle growth and steroidogenesis. These compounds also alter the expression of genes related to hormone regulation and apoptosis.
Article
Genetics & Heredity
Clotilde Maurice, Mathieu Dalvai, Romain Lambrot, Astrid Deschenes, Marie-Pier Scott-Boyer, Serge McGraw, Donovan Chan, Nancy Cote, Ayelet Ziv-Gal, Jodi A. Flaws, Arnaud Droit, Jacquetta Trasler, Sarah Kimmins, Janice L. Bailey
Summary: The study found that paternal exposure to POPs pollutants can impact the development and pregnancy outcomes of offspring, with this effect potentially explained by sperm DNA methylation. Experimental results suggest that the paternal methylome is sensitive to the environment, with some perturbations persisting for at least two subsequent generations.
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.