Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 47, Issue 24, Pages 10071-10075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ie800973y
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- The Netherlands Ministry of Economic Affairs
- B-Basic partner organizations
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The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P(o/w) values), product selectivity, and extractant regeneration.
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